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BIOSS INC
Artikel-Nr:
(BOSSBS-6846R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6846R-A680
Lokale Artikelnummer::
BOSSBS-6846R-A680
Beschreibung:
Nucleostemin is a protein found in the nucleoli of embryonic stem cells, adult CNS stem cells, primitive cells in the bone marrow and cancer cells. It is not in the differentiated cells of most adult tissues. It has been suggested to play a role in controlling the cell cycle progression in stem cells and cancer cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2524R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2524R-A350
Lokale Artikelnummer::
BOSSBS-2524R-A350
Beschreibung:
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1657R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1657R-CY5
Lokale Artikelnummer::
BOSSBS-1657R-CY5
Beschreibung:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1851R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1851R-HRP
Lokale Artikelnummer::
BOSSBS-1851R-HRP
Beschreibung:
Dual specificity phosphatase that dephosphorylates MAP kinase MAPK1/ERK2 on both 'Thr-183' and 'Tyr-185', regulating its activity during the meiotic cell cycle.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0734R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0734R-A350
Lokale Artikelnummer::
BOSSBS-0734R-A350
Beschreibung:
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation. Required for normal branching morphogenesis. Growth factor active on keratinocytes. Possible major paracrine effector of normal epithelial cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5519R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5519R
Lokale Artikelnummer::
BOSSBS-5519R
Beschreibung:
Neuropilin 1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both Vascular Endothelial Growth Factor and Semaphorin family members. Neuropilin 1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15373R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15373R-CY3
Lokale Artikelnummer::
BOSSBS-15373R-CY3
Beschreibung:
GPCR TAS1R1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15021R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15021R-CY7
Lokale Artikelnummer::
BOSSBS-15021R-CY7
Beschreibung:
Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma. The C1orf141 gene product has been provisionally designated C1orf141 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12431R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12431R-A555
Lokale Artikelnummer::
BOSSBS-12431R-A555
Beschreibung:
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11492R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11492R-A750
Lokale Artikelnummer::
BOSSBS-11492R-A750
Beschreibung:
The UNC5H family of proteins act as transmembrane receptors for netrin-1 and play a crucial role in axon guidance and migration of neural cells. In fact, UNC5H receptors express widely in cells that migrate, where they bind the G protein G Alpha 1-2 to inhibit G protein Signalling. Additionally, UNC5H receptors induce apoptosis when cleaved by a caspase, producing an intracellular fragment containing a death domain, but this activity is blocked by the binding of netrin-1. The expression of UNC5H receptors is down-regulated in multiple cancers, including colorectal, breast, ovary, uterus, stomach, lung, and kidney cancers. Hence, in the absence of netrin-1, UNC5H receptors act as tumour suppressors by inhibiting anchorage-independent growth and invasion, but mutation of these receptors provides a potential mechanism for tumourigenicity. UNC5H2, also designated unc-5 homolog B or p53-regulated receptor for death and life protein 1 (p53RDL1) is highly expressed in brain with lower levels of expression observed in developing lung, cartilage, kidney and hematopoietic and immune tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3048R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3048R-A750
Lokale Artikelnummer::
BOSSBS-3048R-A750
Beschreibung:
Beta Arrestin 1 is a member of a family of proteins that are widely expressed but especially abundant in the central nervous system. Serving as an adaptor or scaffold molecule, beta Arrestin 1 is essential for mitogenic signaling. It mediates agonist dependent desensitization and internalization of G protein coupled receptors (GPCRs, e.g., beta 2 adrenergic receptor). After binding to their ligand and interacting with heterotrimeric G proteins, GPCRs are phosphorylated by G protein receptor kinases (GRKs) on serine residues. Beta Arrestin 1 has important roles in the cytoplasm and at the plasma membrane in the desensitization and internalization of G protein coupled receptors (GPCRs) and is increasingly appreciated to play an important role in the endocytosis and signaling of GPCRs. Beta Arrestin 1 in the cytosol is phosphorylated by ERK1 and 2 on serine 412 in a negative feedback mechanism and binds to the phosphorylated receptors at the plasma membrane. Serine 412 is then dephosphorylated and the GPCRs are internalized, leading to activation of the Ras, Raf, ERK1 and 2 signaling pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0027R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0027R-A555
Lokale Artikelnummer::
BOSSBS-0027R-A555
Beschreibung:
High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5632R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5632R-A555
Lokale Artikelnummer::
BOSSBS-5632R-A555
Beschreibung:
Synapsin I is a member of the synapsin family. Synapsins are neuronal phosphoproteins which associate with the cytoplasmic surface of synaptic vesicles. Family members are characterized by common protein domains, and they are implicated in synaptogenesis and the modulation of neurotransmitter release, suggesting a potential role in several neuropsychiatric diseases. This member of the synapsin family plays a role in regulation of axonogenesis and synaptogenesis. The protein serves as a substrate for several different protein kinases and phosphorylation may function in the regulation of this protein in the nerve terminal. Mutations of the Synapsin I gene may be associated with X linked disorders with primary neuronal degeneration such as Rett syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4196R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4196R-A750
Lokale Artikelnummer::
BOSSBS-4196R-A750
Beschreibung:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6028R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6028R-A647
Lokale Artikelnummer::
BOSSBS-6028R-A647
Beschreibung:
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1826R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1826R-A555
Lokale Artikelnummer::
BOSSBS-1826R-A555
Beschreibung:
This gene encodes the beta C chain of inhibin, a member of the TGF-beta superfamily. This subunit forms heterodimers with beta A and beta B subunits. Inhibins and activins, also members of the TGF-beta superfamily, are hormones with opposing actions and are involved in hypothalamic, pituitary, and gonadal hormone secretion, as well as growth and differentiation of various cell types.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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