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BIOSS INC
Artikel-Nr:
(BOSSBS-13694R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13694R-A647
Lokale Artikelnummer::
BOSSBS-13694R-A647
Beschreibung:
NOSTRIN (nitric oxide synthase trafficker isoform 1), also known as endothelial nitric oxide synthase traffic inducer, is a member of the Pombe Cdc15 homology (PCH) family of proteins. NOSTRIN is expressed in the vascular endothelial cells of highly vascularized tissues such as placenta, lung, kidney and heart. It consists of an N-terminal Cdc15 domain with an FCH (Fes/CIP homology) region, two coiled coil domains and a C-terminal SH3 domain. NOSTRIN typically exists as a trimer. It functions as an adaptor protein binding to caveolin-1 via an internal domain and NOS3 via its SH3 domain, forming a ternary complex which facilitates caveolar transport of NOS3. The NOS3 protein is responsible for the production of nitric oxide (NO), a potent mediator in various biological processes. The translocation of NOS3 from the plasma membrane to intracellular vesicle-like structures diminishes NO production. NOSTRIN also interacts with Dynamin and N-WASP via its SH3 domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1476R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1476R-CY3
Lokale Artikelnummer::
BOSSBS-1476R-CY3
Beschreibung:
This multifunctional protein catalyses the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6520R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6520R-CY3
Lokale Artikelnummer::
BOSSBS-6520R-CY3
Beschreibung:
High-affinity epithelial cell surface receptor for APF. Mediates the anchoring of the endoplasmic reticulum to microtubules.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10462R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10462R-A350
Lokale Artikelnummer::
BOSSBS-10462R-A350
Beschreibung:
Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13746R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13746R-A555
Lokale Artikelnummer::
BOSSBS-13746R-A555
Beschreibung:
The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-23, also known as CLDN23 or CLDNL, is a 292 amino acid multi-pass membrane protein that localizes to cell junctions and belongs to the claudin family. Expressed in stomach and placenta, as well as in germinal center B-cells, claudin-23 is thought to exhibit calcium-dependent cell-adhesion activity through which it plays an essential role in tight junction-specific obliteration of the intercellular space. Human claudin-23 shares 80% sequence similarity with its mouse counterpart, suggesting a conserved role between species. Overexpression of claudin-23 is associated with colon tumors, implicating claudin-23 as a possible metastasis factor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2457R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2457R-HRP
Lokale Artikelnummer::
BOSSBS-2457R-HRP
Beschreibung:
TNFRSF14 is a type I membrane protein belonging to the TNF receptor superfamily. This receptor mediates herpes virus entry into cells during infection. TNFRSF14 is able to inhibit the proliferation, activation, and cytokine production of T cells. It has an extracellular domain containing several cysteine-rich repeats and a short cytoplasmic region containing a TRAF (TNF receptor-associated factor) interaction domain. The extracellular domain of TNFRSF14 interacts with the herpes simplex virus envelope glycoprotein D. TNFRSF14 binds two cellular ligands: lymphotoxin alpha and LIGHT. LIGHT is a transmembrane protein expressed and shed from the surface of activated T cells, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes. The LIGHT:TNFRSF14 interaction controls immune response functions by cell death induction as well as cell activation. TNFRSF14 is expressed by peripheral blood T cells, B cells, monocytes and in various tissues enriched in lymphoid cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3067R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3067R-HRP
Lokale Artikelnummer::
BOSSBS-3067R-HRP
Beschreibung:
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0987R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0987R-A488
Lokale Artikelnummer::
BOSSBS-0987R-A488
Beschreibung:
Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12229R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12229R-A488
Lokale Artikelnummer::
BOSSBS-12229R-A488
Beschreibung:
May be involved in transcriptional regulation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8218R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8218R-CY7
Lokale Artikelnummer::
BOSSBS-8218R-CY7
Beschreibung:
Encoding over 300 genes, chromosome 18 contains about 76 million bases. Trisomy 18, or Edwards syndrome, is the second most common trisomy after Downs syndrome. Symptoms of Edwards syndrome include low birth weight, a variety of physical development defects, heart deformations and breathing difficulty. Translocation between chromosome 18 and 14 is the most common translocation in cancers and occurs in follicular lymphomas. Niemann-Pick disease, hereditary hemorrhagic telangiectasia and erythropoietic protoporphyria are associated with chromosome 18. The TGF∫ modulators, Smad2, Smad4 and Smad7 are encoded by chromosome 18. The FAM59A gene product has been provisionally designated FAM59A pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7594R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7594R-A680
Lokale Artikelnummer::
BOSSBS-7594R-A680
Beschreibung:
Ankyrins are a family of proteins that link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialised membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described. Truncated muscle-specific isoforms of ankyrin1 resulting from usage of an alternate promoter have also been identified.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8480R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8480R-A647
Lokale Artikelnummer::
BOSSBS-8480R-A647
Beschreibung:
RBMX2 is a 322 amino acid member of the IST3 family that contains one RRM (RNA recognition motif) domain. The RBMX2 gene is intronless, conserved in chimpanzee, dog, cow, mouse, rat, zebrafish, fruit fly, mosquito, C.elegans, S.pombe, S.cerevisiae, K.lactis, E.gossypii, M.grisea, N.crassa, A.thaliana, rice and P.falciparum, and maps to human chromosome Xq25. The X and Y chromosomes are the human sex chromosomes. Chromosome X consists of about 153 million base pairs and nearly 1,000 genes. The combination of an X and Y chromosome lead to normal male development while two copies of X lead to normal female development. More than one copy of the X chromosome with a Y chromosome causes Klinefelter's syndrome. A single copy of X alone leads to Turner's syndrome. More than 2 copies of the X chromosome, in the absence of a Y chromosome, is known as Triple X syndrome. Color blindness, hemophilia, and Duchenne muscular dystrophy are well known X chromosome-linked conditions that affect males more frequently as males carry a single X chromosome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9750R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9750R
Lokale Artikelnummer::
BOSSBS-9750R
Beschreibung:
Anti-ANKRD45 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13028R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13028R-A555
Lokale Artikelnummer::
BOSSBS-13028R-A555
Beschreibung:
Dipeptidyl peptidases (DPPs) mediate regulatory activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. DPPs have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. DPPs can bind specific voltage-gated potassium channels and alter their expression and biophysical properties and may also influence T cells. DPP proteins include DPRP1, DPRP2, DPP3, DPP7, DPP10, DPPX and CD26. DPP10 (dipeptidyl-peptidase 10), also known as DPRP3 (dipeptidyl peptidase IV-related protein 3), DPL2 or DPPY, is a non-functional dipeptidyl peptidase which can bind to the potassium channels KV4.1 and KV4.2. It is a single-pass type II membrane protein expressed in spinal cord, adrenal glands, pancreas and brain tissues and may act as a modulator for cell surface expression and activity of KV4.1 and KV4.2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7652R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7652R-A350
Lokale Artikelnummer::
BOSSBS-7652R-A350
Beschreibung:
Hydrolyzes DNA under acidic conditions with a preference for double-stranded DNA. Plays a major role in the degradation of nuclear DNA in cellular apoptosis during development. Necessary for proper fetal development and for definitive erythropoiesis in fetal liver, where it degrades nuclear DNA expelled from erythroid precursor cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2121R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2121R-CY3
Lokale Artikelnummer::
BOSSBS-2121R-CY3
Beschreibung:
SCYLV
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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