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2-Amino-3-ethylquinoline+hydrochloride
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2-Amino-3-ethylquinoline+hydrochloride
Artikel-Nr:
(BOSSBS-3883R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3883R-A555
Lokale Artikelnummer::
BOSSBS-3883R-A555
Beschreibung:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3267R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3267R-HRP
Lokale Artikelnummer::
BOSSBS-3267R-HRP
Beschreibung:
Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Also involved in the activation of numerous growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. In cerebellar granule neurons, phosphorylated and sumoylated MEF2A represses transcription of NUR77 promoting synaptic differentiation. Associates with chromatin to the ZNF16 promoter.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3710R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3710R-A488
Lokale Artikelnummer::
BOSSBS-3710R-A488
Beschreibung:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4148R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4148R-CY3
Lokale Artikelnummer::
BOSSBS-4148R-CY3
Beschreibung:
PKMYT1 is a member of the serine/threonine protein kinase family. It preferentially phosphorylates and inactivates cell division cycle 2 protein (cdc2), and thus acts as a negative regulator of entry into mitosis (G2 to M transition). It mediates phosphorylation of cdc2 predominantly on 'Thr-14' and is also involved in Golgi fragmentation. It may be involved in phosphorylation of cdc2 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. It may be a downstream target of Notch signaling pathway during eye development. PKMYT1 is negatively regulated by hyperphosphorylation during mitosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4237R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4237R-CY7
Lokale Artikelnummer::
BOSSBS-4237R-CY7
Beschreibung:
On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Binds to BMP-7, BMP-2 and, less efficiently, BMP-4. Binding is weak but enhanced by the presence of type I receptors for BMPs.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10218R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10218R-A555
Lokale Artikelnummer::
BOSSBS-10218R-A555
Beschreibung:
May act as a receptor in regulating T-cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3067R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3067R-FITC
Lokale Artikelnummer::
BOSSBS-3067R-FITC
Beschreibung:
The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42. Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12406R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12406R-CY5
Lokale Artikelnummer::
BOSSBS-12406R-CY5
Beschreibung:
SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain (4). These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases (2). These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes (1,5). The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors (2,6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1047R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1047R-FITC
Lokale Artikelnummer::
BOSSBS-1047R-FITC
Beschreibung:
Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Isoform 2 is defective in its ability to induce IRAK phosphorylation and NF-kappa-B activation and can function as a negative regulator of activation by IL-1 or lipopolysaccharide (LPS). Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes. MyD88-mediated signaling in intestinal epithelial cells is crucial for maintenance of gut homeostasis and controls the expression of the antimicrobial lectin REG3G in the small intestine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11937R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11937R-A350
Lokale Artikelnummer::
BOSSBS-11937R-A350
Beschreibung:
Putative transcription factor. May be implicated in specification and differentiation of neuronal cell lineages in the brain. May participate in kidney development and may be involved in podocyte differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13260R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13260R-FITC
Lokale Artikelnummer::
BOSSBS-13260R-FITC
Beschreibung:
Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13234R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13234R-A555
Lokale Artikelnummer::
BOSSBS-13234R-A555
Beschreibung:
The mammalian FXYD family maintains Na+ and K+ gradients between the intracellular and extracellular milieus of cells in processes such as renal Na+-reabsorption, muscle contraction and neuronal excitability. FXYDs are single-span membrane proteins that share a 35 amino acid signature domain, beginning with the sequence PFXYD and containing seven invariant and six conserved amino acids. Members of the FXYD family include FXYD1 (PLM, phospholemman), FXYD2 (the g subunit of the Na+/K+-ATPase), FXYD3 (Mat8, mammary tumor protein), FXYD4 (CHIF) and FXYD5 (RIC). FXYD6 is expressed in various epithelial cells bordering the endolymph space and in the auditory neurons. FXYD6 co-localizes with Na+/K+-ATPase in the stria vascularis and can be co-immunoprecipitated with Na+/K+-ATPase. After expression, FXYD6 associates with Na+/K+-ATPase alpha1-beta1 and alpha1-beta2 isozymes, which are preferentially expressed in different regions of the inner ear and also with gastric and non-gastric H+/K+-ATPase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1195R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1195R-CY3
Lokale Artikelnummer::
BOSSBS-1195R-CY3
Beschreibung:
ACTH stimulates the adrenal glands to release cortisol. MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin and Met-enkephalin are endogenous opiates.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12243R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12243R-A350
Lokale Artikelnummer::
BOSSBS-12243R-A350
Beschreibung:
Essential for mesoderm formation and axial patterning during embryonic development.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10216R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10216R-A350
Lokale Artikelnummer::
BOSSBS-10216R-A350
Beschreibung:
The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4250R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4250R-A555
Lokale Artikelnummer::
BOSSBS-4250R-A555
Beschreibung:
The three dimensional structure of many extracellular proteins is stabilized by the formation of disulphide bonds. Studies suggest that a microsomal enzyme known as Protein Disulphide Isomerase (PDI) is involved in disulphide-bond formation and isomerization, as well as the reduction of disulphide bonds in proteins. PDI, which catalyses disulphide interchange between thiols and protein dilsulphides, has also been referred to as thiol:protein-disulphide oxidoreductase and as glutathione:insulin transhydrogenase because of its role in reduction of disulphide bonds. The highly conserved sequence Lys-Asp-Glu-Leu (KDEL) is present at the carboxy-terminus of PDI and other soluble endoplasmic reticulum (ER) resident proteins including the 78 and 94 kDa glucose regulated proteins (GRP78 and GRP94 respectively). The presence of carboxy-terminal KDEL appears to be necessary for ER retention and appears to be sufficient to reduce the secretion of proteins from the ER. This retention is reported to be mediated by a KDEL receptor.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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