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BIOSS INC
Artikel-Nr:
(BOSSBS-15269R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15269R-HRP
Lokale Artikelnummer::
BOSSBS-15269R-HRP
Beschreibung:
Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterised by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. The C7orf44 gene product has been provisionally designated C7orf44 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15322R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15322R-A680
Lokale Artikelnummer::
BOSSBS-15322R-A680
Beschreibung:
C9orf21 (chromosome 9 open reading frame 21) is a 226 amino acid protein that belongs to the UPF0308 family and is encoded by a gene that maps to human chromosome 9q22.33. Chromosome 9 consists of about 145 million bases, represents 4% of the human genome and encodes nearly 900 genes. Thought to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterised by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4284R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4284R-A488
Lokale Artikelnummer::
BOSSBS-4284R-A488
Beschreibung:
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4287R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4287R-A488
Lokale Artikelnummer::
BOSSBS-4287R-A488
Beschreibung:
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3735R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3735R-CY7
Lokale Artikelnummer::
BOSSBS-3735R-CY7
Beschreibung:
DNA PK is the key component of the non-homologous end-joining (NHEJ) pathway of DSB repair in mammalian cells. DNA PK consists of a heterodimeric DNA-binding subunit (Ku70/80) and an approximately 465 kDa catalytic subunit (DNA PKcs). DNA PKcs is a serine/threonine protein kinase whose activity is greatly stimulated by its recruitment to DNA breaks by the Ku heterodimer.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0480R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0480R-A647
Lokale Artikelnummer::
BOSSBS-0480R-A647
Beschreibung:
Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0205R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0205R-CY3
Lokale Artikelnummer::
BOSSBS-0205R-CY3
Beschreibung:
GHRF encoded by this gene belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in this gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0505R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0505R-A647
Lokale Artikelnummer::
BOSSBS-0505R-A647
Beschreibung:
Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0203R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0203R-A647
Lokale Artikelnummer::
BOSSBS-0203R-A647
Beschreibung:
Angiotensin I converting Enzyme Inhibitor, ACEI also designated Bradykinin-potentiating peptide. The peptide: PTHIKWGD. Processed active peptide.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0219R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0219R-A488
Lokale Artikelnummer::
BOSSBS-0219R-A488
Beschreibung:
Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Plays an important role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Mediates apoptotic pathways throught association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptors-induced apoptosis remains controvertial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Secreted core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. May alter lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0334R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0334R-CY3
Lokale Artikelnummer::
BOSSBS-0334R-CY3
Beschreibung:
May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3412R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3412R-A488
Lokale Artikelnummer::
BOSSBS-3412R-A488
Beschreibung:
The SHC gene encodes for a signaling and transforming protein containing Src homology 2 and 3 (SH2 and SH3) domains. The SHC gene encodes 2 widely expressed overlapping proteins of 46 and 52 kD, both containing a C-terminal SH2 domain. Adjacent to the SH2 region is a glycine and proline rich region. These 2 proteins differ in their N terminals. SHC proteins are involved in mitogenic signal transduction and act by coupling growth factor receptors to the RAS signaling pathway. The protein encoded by the SHC1 gene is thought to act as an adaptor in many signal transduction pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11059R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11059R-CY3
Lokale Artikelnummer::
BOSSBS-11059R-CY3
Beschreibung:
Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins as the cells are repelled, rather than attracted, by the netrin gradient. Neogenin serves as the primary guidance receptor for netrin-3. Netrin-2 and the corresponding mouse homolog netrin-3 are expressed primarily in the lower two-thirds of the spinal cord, and, like netrin-1, they can either attract or repel commissural axons at a distance. Netrin-3 proteins are associated with the axon fibers projecting from motor neurons and from neurons within sympathetic and sensory ganglia, suggesting that netrin-3 may be involved in pathfinding and fasciculation of axon projection. Neogenin serves as the primary guidance receptor for netrin-3. During peripheral nerve development, high netrin-3 expression has been detected in mesenchymal cells, sensory ganglia and muscles. In humans, the gene encoding for the netrin-3 protein is localized to chromosome 16p13.3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11068R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11068R-FITC
Lokale Artikelnummer::
BOSSBS-11068R-FITC
Beschreibung:
The Tenascin family of extracellular matrix proteins includes Tenascin (also designated cytotactin or Tenascin-C), Tenascin-R (also designated Restrictin or Janusin) and Tenascin-X. Tenascin proteins function as substrate-adhesion molecules (SAMs) and are involved in regulating numerous developmental processes, such as morphogenetic cell migration and organogenesis. The Tenascin family proteins arise from various splicing events in the region of coding for FNIII repeats. Tenascin and Tenascin-X are expressed in several tissues during embryogenesis, and in adult tissues undergoing active remodel-ing such as healing wounds and tumors. Tenascin-R (TN-R) is expressed on the surface of neurons and glial cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0637R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0637R-CY7
Lokale Artikelnummer::
BOSSBS-0637R-CY7
Beschreibung:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0542R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0542R-CY5.5
Lokale Artikelnummer::
BOSSBS-0542R-CY5.5
Beschreibung:
The cell division control protein cdc2, also known as cyclin dependent kinase 1 (Cdk1) or p34/cdk1, plays a key role in the control of the eukaryotic cell cycle, where it is required for entry into S phase and mitosis. Cdc2 exists as a complex with both cyclin A and cyclin B. The best characterized of these associations is the Cdc2 p34 cyclin B complex, which is required for the G2 to M phase transition. Activation of Cdc2 is controlled at several steps including cyclin binding and phosphorylation of threonine 161. However, the critical regulatory step in activating cdc2 during progression into mitosis appears to be dephosphorylation of Tyr15 and Tyr14. Phosphorylation at Tyr15 and inhibition of Cdc2 is carried out by WEE1 and MIK protein kinases while Tyr15 dephosphorylation and activation of Cdc2 is carried out by the cdc25 phosphatase. The isoform CDC2deltaT is found in breast cancer tissues. Furthermore, cdc2/Cdk1 is a key mediator of neuronal cell death in brain development and degeneration.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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