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BIOSS INC
Artikel-Nr:
(BOSSBS-6110R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6110R-A555
Lokale Artikelnummer::
BOSSBS-6110R-A555
Beschreibung:
SPARC (secreted protein acidic and rich in cysteine) is a phosphorylated, acidic, glycine-rich glycoprotein that is secreted by endothelial cells and is present in large amounts in the parietal endoderm of mouse embryos and in human placenta. SPARC-like protein 1 (SPARCL1), also known as high endothelial venule protein (Hevin) or MAST9, is a 664 amino acid member of the SPARC family of proteins. Highly expressed in lymph node, heart, lung, brain, skeletal muscle, ovary, colon and small intestine, SPARCL1 is a secreted protein that contains one EF-hand domain, one follistatin-like domain and one Kazal-like domain. SPARCL1 is implicated to play a role in neuronal remodeling and tumor suppression. The gene encoding SPARCL1 maps to chromosome 4q22.1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2432R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2432R-A647
Lokale Artikelnummer::
BOSSBS-2432R-A647
Beschreibung:
E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2210R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2210R-CY7
Lokale Artikelnummer::
BOSSBS-2210R-CY7
Beschreibung:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9450R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9450R-A647
Lokale Artikelnummer::
BOSSBS-9450R-A647
Beschreibung:
Cytidine is a nucleoside formed by a cytosine attached to a ribose ring via a beta-N1-glycosidic bond. DNA is methylated on cytidines by DNA methylases (DNMTs)to generate 5-methylcytidine (5-mC), a potent epigenetics marker and regulator of gene expression. The reverse reaction (cytidine demethylation) starts with its oxidation to hydroxymethyl- (5-hmC), formyl- (5-fC), and carboxy- (5-caC) cytidine. Several enzymes, including the Tet family of proteins have been implicated in cytidine demethylation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4276R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4276R-CY5
Lokale Artikelnummer::
BOSSBS-4276R-CY5
Beschreibung:
ELAC2 is a zinc phosphodiesterase which displays some tRNA 3' processing endonuclease activity. It is thought to be involved in tRNA maturation, acting by removing a 3' trailer from precursor tRNA. ELAC2 also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. A number of allelic variants have been investigated in hereditary prostate cancer.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4820R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4820R-A680
Lokale Artikelnummer::
BOSSBS-4820R-A680
Beschreibung:
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3695R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3695R-HRP
Lokale Artikelnummer::
BOSSBS-3695R-HRP
Beschreibung:
NTF97 is involved in nuclear protein import, either by associating itself with an adapter protein (for example, importin-alpha subunit which binds to nuclear localization signals (NLS) in cargo substrates), or by acting autonomously as a nuclear transport receptor (serves as NLS receptor, docking of the importin/substrate complex to the nuclear pore complex).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5334R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5334R-A680
Lokale Artikelnummer::
BOSSBS-5334R-A680
Beschreibung:
Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4835R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4835R-CY3
Lokale Artikelnummer::
BOSSBS-4835R-CY3
Beschreibung:
Could be an important component in vesicular trafficking cycling between the Golgi complex and the apical plasma membrane. Could be involved in myelin biogenesis and/or myelin function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0427R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0427R
Lokale Artikelnummer::
BOSSBS-0427R
Beschreibung:
Anti-P311 Protein Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4775R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4775R-FITC
Lokale Artikelnummer::
BOSSBS-4775R-FITC
Beschreibung:
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit, which is the product of this gene, and the modulatory beta subunit. Intracellular calcium regulates the physical association between the alpha and beta subunits. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10419R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10419R-A680
Lokale Artikelnummer::
BOSSBS-10419R-A680
Beschreibung:
This gene belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways. The protein encoded by this gene is a dimeric enzyme that catalyses the reversible isomerization of glucose-6-phosphate and fructose-6-phosphate. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in this gene are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5063R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5063R-CY7
Lokale Artikelnummer::
BOSSBS-5063R-CY7
Beschreibung:
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15531R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15531R-CY7
Lokale Artikelnummer::
BOSSBS-15531R-CY7
Beschreibung:
IBRDC1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1545R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1545R-CY5.5
Lokale Artikelnummer::
BOSSBS-1545R-CY5.5
Beschreibung:
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodelling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10446R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10446R-CY7
Lokale Artikelnummer::
BOSSBS-10446R-CY7
Beschreibung:
Human papilloma viruses (HPVs) can be classified as either high risk or low risk according to their association with cancer. HPV16 and HPV18 are the most common of the high risk group while HPV6 and HPV11 are among the low risk types. Approximately 90% of cervical cancers contain HPV DNA of the high risk types. Mutational analysis have shown that the E6 and E7 genes of the high risk HPVs are necessary and sufficient for HPV transforming function. The specific interactions of the E6 and E7 proteins with p53 and pRB, respectively, correlate with HPV high and low risk classifications. The high risk HPV E7 proteins bind to pRB with a higher affinity than do the low risk HPV proteins, and only the high risk HPV E6 proteins form detectable complexes with p53 in vitro.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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