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BIOSS INC
Artikel-Nr:
(BOSSBS-3404R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3404R-CY5
Lokale Artikelnummer::
BOSSBS-3404R-CY5
Beschreibung:
The steady state of protein tyrosyl phosphorylation in cells is regulated by the opposing action of tyrosine kinases and protein tyrosine phosphatases (PTPs). Several groups have independently identified a non transmembrane PTP, designated SHPTP1 (also known as PTP1C, HCP and SHP), which is primarily expressed in hematopoietic cells and characterized by the presence of two SH2 domains N terminal to the PTP domain. A second and much more widely expressed PTP with SH2 domains, SHPTP2 (also designated PTP1D and Syp), has been identified. SHP2 is a protein tyrosine phosphatase that is widely expressed and plays a regulatory role in various cell signaling events that are important for many cell functions, such as mitogenic activation, metabolic control, transcription regulation, and cell migration.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8576R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8576R-CY3
Lokale Artikelnummer::
BOSSBS-8576R-CY3
Beschreibung:
PLEKHJ1 is a 149 amino acid phosphoprotein that contains one PH (pleckstrin homology) domain and is expressed in testis and liver. The gene that encodes PLEKHJ1 maps to human chromosome 19, which consists of approximately 63 million bases and makes up over 2% of human genomic DNA. Chromosome 19 contains the greatest gene density of the human chromosomes and is the genetic home for a number of immunoglobulin superfamily members, including killer cell and leukocyte Ig-like receptors, ICAMs, the CEACAM and PSG families, and Fc?receptors. Key genes for eye color and hair color also map to chromosome 19. Peutz-Jeghers syndrome, spinocerebellar ataxia type 6, the stroke disorder CADASIL, hypercholesterolemia and insulin-dependent diabetes are also linked to chromosome 19.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8874R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8874R-A555
Lokale Artikelnummer::
BOSSBS-8874R-A555
Beschreibung:
The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8333R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8333R-A488
Lokale Artikelnummer::
BOSSBS-8333R-A488
Beschreibung:
RDH13, also known as all-trans and 9-cis retinol dehydrogenase 13 or SDR7C3, is a 331 amino acid mitochondrial protein belonging to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed, mostly in eye, pancreas, placenta and lung, RDH13 localizes on the outer side of the inner mitochondrial membrane. Related to microsomal retinoid oxidoreductase RDH11, RDH13 is considered to be a major enzyme among the RDH family of proteins. Catalytically active, RDH13 recognizes retinoids as substrates and may function in retinoic acid production. RDH13 may function to protect the mitochondria against oxidative stress. Leber congenital amaurosis (LCA) type 3, an inherited autosomal recessive retinal disease, has been associated with defects of RDH13. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15113R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15113R-FITC
Lokale Artikelnummer::
BOSSBS-15113R-FITC
Beschreibung:
Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf7 gene product has been provisionally designated C20orf7 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2615R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2615R-A680
Lokale Artikelnummer::
BOSSBS-2615R-A680
Beschreibung:
Receptor for interleukin 18 (IL-18). Binding to the agonist leads to the activation of NF-kappa-B.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3899R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3899R-A488
Lokale Artikelnummer::
BOSSBS-3899R-A488
Beschreibung:
Has a role in maintaining calcium homeostasis. Catalyzes the NADPH-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9336R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9336R-A680
Lokale Artikelnummer::
BOSSBS-9336R-A680
Beschreibung:
Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). MARCH2 (membrane-associated ring finger (C3HC4) 2), also known as RNF172 or HSPC240, is a 246 amino acid multi-pass membrane protein that localises to the endoplasmic reticulum and contains one RING-CH-type zinc finger. Expressed in a variety of tissues, MARCH2 functions as an E3 ubiquitin-protein ligase that is thought to mediate the ubiquitination and subsequent degradation of CD71 and B7-2 and may be involved in endosomal protein trafficking.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15567R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15567R-A488
Lokale Artikelnummer::
BOSSBS-15567R-A488
Beschreibung:
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15211R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15211R-CY7
Lokale Artikelnummer::
BOSSBS-15211R-CY7
Beschreibung:
C5orf55
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3842R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3842R-A350
Lokale Artikelnummer::
BOSSBS-3842R-A350
Beschreibung:
EIF3S3 binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA. It associates with the p170 subunit of EIF3. The EIF3 is composed of at least 12 different subunits.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6369R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6369R-A555
Lokale Artikelnummer::
BOSSBS-6369R-A555
Beschreibung:
This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4938R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4938R-A750
Lokale Artikelnummer::
BOSSBS-4938R-A750
Beschreibung:
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3090R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3090R-A680
Lokale Artikelnummer::
BOSSBS-3090R-A680
Beschreibung:
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2942R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2942R-A750
Lokale Artikelnummer::
BOSSBS-2942R-A750
Beschreibung:
HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2284R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2284R-A750
Lokale Artikelnummer::
BOSSBS-2284R-A750
Beschreibung:
Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species jumping ability. Influenza A Virus Hemagglutinin recognize the influenza hemagglutinin epitope, which has been used extensively as a general epitope tag in expression vectors. The extreme specificity of this antibody allows for unambiguous identification and quantitative analysis of the tagged protein.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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