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BIOSS INC
Artikel-Nr:
(BOSSBS-6997R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6997R-A555
Lokale Artikelnummer::
BOSSBS-6997R-A555
Beschreibung:
Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11035R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11035R-CY5
Lokale Artikelnummer::
BOSSBS-11035R-CY5
Beschreibung:
TNF Alpha-IP 8L2 (tumor necrosis factor, alpha-induced protein 8-like 2), also known as TIPE2, is a 184 amino acid protein that shares 94% identity with its mouse counterpart and belongs to the TNFAIP8 family. Expressed in spleen, thymus, small intestine and lymph node with lower levels present in colon, lung and skin, TNF Alpha-IP 8L2 plays a role in maintaining immune homeostasis, specifically by acting as a negative regulator of both innate and adaptive immunity. In addition, TNF?IP 8L2 functions as a negative regulator of T-cell receptor function and is thought to promote Fas-induced apoptosis. The gene encoding TNF?IP 8L2 maps to human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2611R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2611R-A350
Lokale Artikelnummer::
BOSSBS-2611R-A350
Beschreibung:
Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NF-kappa-B and MAPK pathways. Acts synergically with IL22 in inducing the expression of antibacterial peptides, including S100A8, S100A9, REG3A and REG3G. Synergy is also observed with TNF and IL1B in inducing DEFB2 from keratinocytes. Depending on the type of insult, may have both protective and pathogenic properties, either by maintaining epithelial homeostasis after an inflammatory challenge or by promoting inflammatory phenotype. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1975R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1975R-A647
Lokale Artikelnummer::
BOSSBS-1975R-A647
Beschreibung:
Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2 ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2 self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53 ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53 stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8452R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8452R-A750
Lokale Artikelnummer::
BOSSBS-8452R-A750
Beschreibung:
SNAPC3 is part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. SNAPC3 binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. SNAPC3 recruits TBP and BRF2 to the U6 snRNA TATA box.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9611R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9611R-A750
Lokale Artikelnummer::
BOSSBS-9611R-A750
Beschreibung:
CLLD6, is a 196 amino acid protein that contains one B30.2/SPRY domain. Expression of CLLD6 is found at highest levels in heart, skeletal muscle and testis, with lower levels found in thymus, peripheral blood leukocytes, lymph node and bone marrow. Existing as two alternatively spliced isoforms, CLLD6 maps to human chromosome 13, which comprises nearly 4% of human DNA and contains about 114 million base pairs and 400 genes. Key tumour suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene. RB1 encodes a crucial tumour suppressor protein which, when defective, leads to malignant growth in the retina and has been implicated in a variety of other cancers. The gene SLITRK1, which is associated with Tourette syndrome, is on chromosome 13. As with most chromosomes, polysomy of part or all of chromosome 13 is deleterious to development and decreases the odds of survival.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5034R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5034R-FITC
Lokale Artikelnummer::
BOSSBS-5034R-FITC
Beschreibung:
Apolipoprotein A II is the second most abundant protein of the high density lipoprotein particles. The apolipoprotein A II gene consists of 4 exons and 3 introns. The four exons encode the 5' untranslated region, pre peptide, a short N terminal domain and a C terminal domain composed of a variable number of lipid binding amphipathic helices. Familial apolipoprotein A II deficiency may result from a splice junction alteration which blocks splicing of intron 3 from the primary transcript and result in the formation of a non functional mRNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-19195R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-19195R-A750
Lokale Artikelnummer::
BOSSBS-19195R-A750
Beschreibung:
Protein kinase which plays an important role in the G2/M checkpoint response to DNA damage. Controls degradation of CDC25A by directly phosphorylating it on residues whose phosphorylation is required for BTRC-mediated polyubiquitination and degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6856R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6856R-CY7
Lokale Artikelnummer::
BOSSBS-6856R-CY7
Beschreibung:
Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID.Tissue specificity: Widely expressed with highest levels in heart, brain and skeletal muscle.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8471R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8471R-A647
Lokale Artikelnummer::
BOSSBS-8471R-A647
Beschreibung:
Members of the F-box protein family, such as FBXO33, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1, cullin and F-box proteins act as protein-ubiquitin ligases and mediates the ubiquitination and subsequent proteasomal degradation of target proteins. FBXO33 probably recognizes and binds to phosphorylated target proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8204R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8204R-HRP
Lokale Artikelnummer::
BOSSBS-8204R-HRP
Beschreibung:
NEEP21, also known as Brain neuron cytoplasmic protein 1, NSG1 (neuron-specific proteins family member 1), P21 or D4S234E, is a single pass type II membrane protein belonging to the NSG family. It is highly expressed during neuronal maturation but its expression is downregulated in adult tissues. NEEP21 predominantly localizes to Rab 4-positive early endosomes in the somatodendritic neuronal compartment and is essential for proper receptor sorting and recycling in neurons. It associates with GRIP1 and GluR-2 and mediates the surface expression of GluR-2. When this interaction is interrupted, GluR-2 accumulates in early endosomes and leads to changes in evoked synaptic current properties. In addition, NEEP21 forms a complex with the SNARE protein, Syntaxin 13 (also known as Syntaxin 12), and participates in the recycling of transferrin receptors (TFRs) and NTR2 (neurotensin receptor 2).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11530R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11530R-HRP
Lokale Artikelnummer::
BOSSBS-11530R-HRP
Beschreibung:
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase).The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2183R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2183R
Lokale Artikelnummer::
BOSSBS-2183R
Beschreibung:
Anti-CLDN11 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15472R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15472R-A750
Lokale Artikelnummer::
BOSSBS-15472R-A750
Beschreibung:
HGD is a 445 amino acid protein that belongs to the homogentisate dioxygenase family and is involved in the pathway of amino acid degradation. Expressed at high levels in kidney, colon, liver, prostate and small intestine, HGD uses iron as a cofactor to catalyse the oxygen-dependent conversion of homogentisate to 4-maleylacetoacetate, a reaction that is the fourth step in the creation of L-phenylalanine from fumarate and acetoacetic acid. Defects in the gene encoding HGD are the cause of alkaptonuria (AKU), an autosomal recessive disorder that is characterised by urine that turns dark on standing and alkalinisation, black ochronotic pigmentation of cartilage and collagenous tissues and spine arthritis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6681R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6681R-CY5
Lokale Artikelnummer::
BOSSBS-6681R-CY5
Beschreibung:
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER. Required for maintenance of ER network. Implicated in the suppression of cell death.Tissue specificity: Isoform 1 is highly expressed in heart, brain, liver skeletal muscle and pancreas. Isoform 3 is moderately expressed in placenta, lung and kidney. Isoform 4 is highly expressed in testis and small intestine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13041R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13041R
Lokale Artikelnummer::
BOSSBS-13041R
Beschreibung:
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin (By similarity). Leumorphin has a typical opiod activity and may have anti-apoptotic effect.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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