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28 361 results were found
PROSCI
Artikel-Nr:
(PRSI29-315)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-315
Lokale Artikelnummer::
PRSI29-315
Beschreibung:
PRKRA contains 3 DRBM (double-stranded RNA-binding) domains. It appears to have a pro-apoptotic function that may be suppressed in the presence of growth factor and activates EIF2AK2 in absence of double stranded RNA (dsRNA).
VE:
1 * 50 µG
Artikel-Nr:
(PRSI29-893)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-893
Lokale Artikelnummer::
PRSI29-893
Beschreibung:
MTA2 modulates the enzymatic activity of the histone deacetylase core complex.The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. This gene is found to be deleted in Williams syndrome.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI31-082)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
31-082
Lokale Artikelnummer::
PRSI31-082
Beschreibung:
PDCD4 is a protein localized to the nucleus in proliferating cells. Expression of this gene is modulated by cytokines in natural killer and T cells. The gene product is thought to play a role in apoptosis but the specific role has not yet been determined. Two transcripts encoding different isoforms have been identified.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI45-679)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
45-679
Lokale Artikelnummer::
PRSI45-679
Beschreibung:
Anti-GRIK1 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI29-402)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-402
Lokale Artikelnummer::
PRSI29-402
Beschreibung:
IRAK3 contains 1 protein kinase domain and 1 death domain and belongs to the Ser/Thr protein kinase family, Pelle subfamily. It inhibits dissociation of IRAK1 and IRAK4 from the Toll-like receptor signaling complex by either inhibiting the phosphorylation of IRAK1 and IRAK4 or stabilizing the receptor complex.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3559)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3559
Lokale Artikelnummer::
PRSI3559
Beschreibung:
CTRP2 Antibody: Adipose tissue of an organism plays a major role in regulating physiologic and pathologic processes such as metabolism and immunity by producing and secreting a variety of bioactive molecules termed adipokines. One highly conserved family of adipokines is adiponectin/ACRP30 and its structural and functional paralogs, the C1q/tumor necrosis factor-alpha-related proteins (CTRPs) 1-7. Unlike adiponectin, which is expressed exclusively by differentiated adipocytes, the CTRPs are expressed in a wide variety of tissues. These proteins are thought to act mainly on liver and muscle tissue to control glucose and lipid metabolism. An analysis of the crystal structure of adiponectin revealed a structural and evolutionary link between TNF and C1q-containing proteins, suggesting that these proteins arose from a common ancestral innate immunity gene. Of the CTRPs, CTRP2 is most similar structurally and functionally to adiponectin. Recombinant CTRP2 rapidly activated AMPK and MAPK in cultured C2C12 cells, leading to increased glycogen accumulation and fatty acid oxidation.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI25-064)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-064
Lokale Artikelnummer::
PRSI25-064
Beschreibung:
PAX7 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box gene 7 is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown. This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box 7 gene is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-221)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-221
Lokale Artikelnummer::
PRSI91-221
Beschreibung:
Nucleoside-Diphosphate Kinases (NDKs) are enzymes that catalyze the exchange of phosphate groups between different nucleoside diphosphates. NDKs Possesse nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3-5 exonuclease activities. NDKs involved in cell proliferation, differentiation and development, signal transduction, G protein-coupled receptor endocytosis, and gene expression and required for neural development including neural patterning and cell fate determination. Prokaryotic NDK forms a functional homotetramer.There are two isoforms of NDK in humans: NDK-A and NDK-B. Both have very similar structure, and can combine in any proportion to form functional NDK hexamers.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-617)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-617
Lokale Artikelnummer::
PRSI91-617
Beschreibung:
Mouse stem cell factor (SCF), is the ligand for the receptor-type protein-tyrosine kinase KIT. It plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. It also promotes phosphorylation of PIK3R1, which is the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-132)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-132
Lokale Artikelnummer::
PRSI91-132
Beschreibung:
Melanoma Inhibitory Activity Protein (MIA) is an autocrine growth regulatory protein secreted from chondrocytes and malignant melanoma cells, which was the first discovered member of a family of secreted cytokines termed the MIA/OTOR family. The four known members of this family: MIA, MIA2, OTOR and TANGO each contain a Src homology-3 (SH3)-like domain. MIA acts as a potent tumor cell growth inhibitor for malignant melanoma cells and some other neuroectodermal tumors, including gliomas, in an autocrine fashion and promotes melanoma metastasis by binding competitively to fibronectin and laminin in a manner that results in melanoma cell detachment from the extracellular matrix in vivo. The protein MIA has been shown to represent a very sensitive and specific serum marker for systemic malignant melanoma that might be useful for staging of primary melanomas, detection of progression from localized to metastatic disease during follow-up, and monitoring therapy of advanced melanomas. Elevated levels of MIA may represent a clinically useful marker for diagnosis of melanoma metastasis as well as a potential marker for rheumatoid arthritis.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5703)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5703
Lokale Artikelnummer::
PRSI5703
Beschreibung:
TCC52 Antibody: Cancer-testis (CT) antigens are a type of antigen whose expression is highly restricted, primarily in normal testis, but aberrantly in different tumor types. Their immunogenicity in cancer patients makes them prime targets for immunotherapy of human tumors. One such CT antigen is TCC52, a novel centrosomal protein. TCC52 is a WD repeat-containing protein that interacts with the COP9 signalosome, a macromolecular complex that interacts with cullin-RING E3 ligases and regulates their activity by hydrolyzing cullin-Nedd8 conjugates. The normal biological function of this protein is not known at this time.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI5859P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5859P
Lokale Artikelnummer::
PRSI5859P
Beschreibung:
CaBP7 peptide is used for blocking the activity of CaBP7 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI63-210)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
63-210
Lokale Artikelnummer::
PRSI63-210
Beschreibung:
For WB starting dilution is: 1:1000. For IHC-P starting dilution is: 1:50~100. For FACS starting dilution is: 1:10~50.
VE:
1 * 400 µl
New Product
Artikel-Nr:
(PRSI96-747)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-747
Lokale Artikelnummer::
PRSI96-747
Beschreibung:
Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily. TRAILR1 / TNFRSF10A contains 1 death domain and 3 TNFR-Cys repeats. TNFRSF10A / DR4 is widely expressed and high levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K-562 erythroleukemia cells, MCF-7 breast carcinoma cells and activated T-cells. APO2 / TNFRSF10A is receptor for the cytotoxic ligand TNFSF10 / TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TRAILR-1 / DR4 / CD261 promotes the activation of NF-kappa-B.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI63-321)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
63-321
Lokale Artikelnummer::
PRSI63-321
Beschreibung:
For WB starting dilution is: 1:1000. For IHC-P starting dilution is: 1:10~50.
VE:
1 * 200 µl
New Product
Artikel-Nr:
(PRSI63-391)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
63-391
Lokale Artikelnummer::
PRSI63-391
Beschreibung:
For WB starting dilution is: 1:1000. For IHC-P starting dilution is: 1:50~100.
VE:
1 * 400 µl
New Product
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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