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PROSCI
Artikel-Nr:
(PRSI3883)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3883
Lokale Artikelnummer::
PRSI3883
Beschreibung:
TIP47 Antibody: Tail-interacting protein (TIP47) is a cytosolic protein essential for the transport of mannose-6-phosphate receptors (MPRs) from endosomes to the trans-Golgi compartments in cells. TIP47 is recruited from the cytoplasm to the late endosomal surface by the Ras-associated protein Rab9 GTPase, enabling it to bind more efficiently to MPR cytoplasmic domains. Recently, it was shown that TIP47 regulates the expression of Rab9, as expression of siRNA to TIP47 in transfected cells dramatically decreased the half-life of the Rab9 protein in addition to stabilizing the subcellular localization of Rab9. At least two isoforms of TIP47 are known to exist.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI3965P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3965P
Lokale Artikelnummer::
PRSI3965P
Beschreibung:
Lipe peptide is used for blocking activity of lipe antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI45-082)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
45-082
Lokale Artikelnummer::
PRSI45-082
Beschreibung:
Anti-LDLRAP1 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI24-008)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
24-008
Lokale Artikelnummer::
PRSI24-008
Beschreibung:
Anti-AGK Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Artikel-Nr:
(PRSI76-176)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-176
Lokale Artikelnummer::
PRSI76-176
Beschreibung:
The VI-PL2 monoclonal antibody reacts with CD61, a type I integral transmembrane glycoprotein also known as integrin beta 3. CD61 forms a complex with CD41 (platelet gpIIb) and CD51 (integrin alphaV). It is expressed on osteoclasts, fibroblasts, platelets, macrophages, and megakaryocytes and appears to bind to fibronectin, vitronectin, thrombospondin, and fibrinogen and vWF. The VI-PL2 antibody is reported to be cross-reactive with baboon, rhesus, and cynomolgus.
VE:
1 * 0,025 mg
New Product
Artikel-Nr:
(PRSI91-972)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-972
Lokale Artikelnummer::
PRSI91-972
Beschreibung:
SUMO3 belongs to the SUMO protein family and operates like ubiquitin. Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polyer. Nevertheless unlike ubiquitin that targets proteins for degration, SUMO3 takes part in several cellular processess, such as nuclear transport, transcription regulation, apoptosis and protein stability. SUMO3 participates in amyloid beta generation and has a key role in the oneset or progression of Alzheimer's disease.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI22-518)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
22-518
Lokale Artikelnummer::
PRSI22-518
Beschreibung:
Anti-APLP1 Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Artikel-Nr:
(PRSI30-924)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
30-924
Lokale Artikelnummer::
PRSI30-924
Beschreibung:
TTC12 contains 3 TPR repeats. Hypermethylation of TTC12 gene may play a role in acute lymphoblastic leukemia. Haplotypic variants in DRD2, ANKK1, TTC12, and NCAM1 are associated with comorbid alcohol and drug dependence.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI33-229)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
33-229
Lokale Artikelnummer::
PRSI33-229
Beschreibung:
Peripheral blood granulocytes are classified into neutrophils, basophils and eosinophils according to the staining characteristics of their cytoplasmic granules. Granule proteins are released by physiologic and pharmacologic stimuli and play important roles in both normal and pathological host immune responses. Eosinophil major basic protein and eosinophil peroxidase (EPX) are granule proteins specific to the eosinophil. This MAb stains eosinophils only and does not stain other peripheral blood cells, including platelets, neutrophils, monocytes, lymphocytes or red blood cells. Human EPX gene product can form a tetramer of two light chains and two heavy chains. Other peroxidase family members include myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO).
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI79-366)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-366
Lokale Artikelnummer::
PRSI79-366
Beschreibung:
Kinase subunit of both mTORC1 and mTORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino-acids. Amino-acid-signaling to mTORC1 is mediated by Rag GTPases, which cause amino-acid-induced relocalization of mTOR within the endomembrane system. Growth factor-stimulated mTORC1 activation involves AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-421', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI62-342)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
62-342
Lokale Artikelnummer::
PRSI62-342
Beschreibung:
For WB starting dilution is: 1:1000. For IHC-P starting dilution is: 1:50~100. For FACS starting dilution is: 1:10~50.
VE:
1 * 400 µl
New Product
Artikel-Nr:
(PRSI77-182)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
77-182
Lokale Artikelnummer::
PRSI77-182
Beschreibung:
The MAb11 monoclonal antibody specifically reacts with human tumor necrosis factor alpha (TNF-alpha), a 157 amino acid non-glycosylated protein. TNF-alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-alpha is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-alpha also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MAB11 antibody was generated from recombinant human TNF and is reported to be a neutralizing antibody.
VE:
1 * 100 Tests
New Product
Artikel-Nr:
(PRSI23-572)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
23-572
Lokale Artikelnummer::
PRSI23-572
Beschreibung:
Anti-GNB2 Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Artikel-Nr:
(PRSI79-396)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-396
Lokale Artikelnummer::
PRSI79-396
Beschreibung:
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI6927P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6927P
Lokale Artikelnummer::
PRSI6927P
Beschreibung:
RAB21 peptide is used for blocking the activity of RAB21 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5837P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5837P
Lokale Artikelnummer::
PRSI5837P
Beschreibung:
TCTN3 peptide is used for blocking the activity of TCTN3 antibody.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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