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2-Formylbenzoyl+chloride
Artikel-Nr:
(BOSSBS-9176R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9176R-A555
Lokale Artikelnummer::
BOSSBS-9176R-A555
Beschreibung:
RNF11
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9001R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9001R-A488
Lokale Artikelnummer::
BOSSBS-9001R-A488
Beschreibung:
Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9485R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9485R-FITC
Lokale Artikelnummer::
BOSSBS-9485R-FITC
Beschreibung:
The ENTHD1 gene is conserved in chimpanzee, dog, cow, mouse and rat, and maps to human chromosome 22q13.1. Chromosome 22 contains over 500 genes and about 49 million bases. Being the second smallest human chromosome, 22 contains a surprising variety of interesting genes. Phelan-McDermid syndrome, Neurofibromatosis type 2 and autism are associated with chromosome 22. A schizophrenia susceptibility locus has been identified on chromosome 22 and studies show that 22q11 deletion symptoms include a high incidence of schizophrenia. Translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein, BCR-Abl, a potent cell proliferation activator found in several types of leukemia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8131R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8131R-FITC
Lokale Artikelnummer::
BOSSBS-8131R-FITC
Beschreibung:
The coiled-coil domain is a structural motif found in proteins that are involved in a diverse array of biological functions such as the regulation of gene expression, cell division, membrane fusion and drug extrusion and delivery. CCDC42 (coiled-coil domain containing 42) is a 316 amino acid protein encoded by a gene that maps to human chromosome 17p13.1. Encoding over 1,200 genes, chromosome 17 comprises over 2.5% of the human genome. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5714R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5714R-A680
Lokale Artikelnummer::
BOSSBS-5714R-A680
Beschreibung:
OVCA1 is required for the first step in the synthesis of diphthamide, a unique posttranslationally modified histidine found only in translation elongation factor-2 (EEF2; MIM 130610). This modification is conserved from archaebacteria to humans and serves as the target for ADP-ribosylation and inactivation of EEF2 by diphtheria toxin (DT) and Pseudomonas exotoxin A. OVCA1 is one of several enzymes involved in synthesis of diphthamide in EEF2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3363R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3363R-A680
Lokale Artikelnummer::
BOSSBS-3363R-A680
Beschreibung:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13367R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13367R-HRP
Lokale Artikelnummer::
BOSSBS-13367R-HRP
Beschreibung:
This gene encodes a protein that is highly similar to the mouse cGMP-dependent protein kinase anchoring protein 42kDa. The mouse protein has been found to localize with the Golgi and recruit cGMP-dependent protein kinase I alpha to the Golgi in mouse testes. It is thought to play a role in germ cell development. Transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12153R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12153R-A488
Lokale Artikelnummer::
BOSSBS-12153R-A488
Beschreibung:
Beta-taxilin promotes nerve regeneration and may be involved in intracellular vesicle transport. Expressed predominantly in cardiac and skeletal muscle, beta-taxilin binds to the coiled coil region of the syntaxin family members STX1A, STX3A, and STX4A. Beta- and gamma-taxilins, bind to the alpha subunit of the nascent polypeptide-associated complex (NAC) and affect its nuclear distribution, suggesting that the taxilin family is involved not only in the translational process through its interaction with NAC but also in the transcriptional process through its interaction with alphaNAC alone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11015R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11015R-A555
Lokale Artikelnummer::
BOSSBS-11015R-A555
Beschreibung:
Phakinin is a membrane-associated and cytoskeletal intermediate filament (IF) protein specific to the eye lens. IFs are cytoskeletal structures that typically contain a head, rod and tail domain. Unlike most IFs, Phakinin completely lacks the C-terminal tail domain thus contributing to the unique structure of the beaded filament that is specific to the lens. Phakinin is required for the assembly of beaded filaments and cytoskeletal networks that are important for the long-term maintenance of optical properties and transparency of the lens. Phakinin copolymerizes with Filensin, another IF protein, to form the 10-nm filamentous structures of the beaded filaments. Phakinin is also capable of self-assembling into filament-like structures that form thicker bundles. Mutations in the gene encoding Phakinin can result in lens cataract.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12528R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12528R-FITC
Lokale Artikelnummer::
BOSSBS-12528R-FITC
Beschreibung:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13234R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13234R-A647
Lokale Artikelnummer::
BOSSBS-13234R-A647
Beschreibung:
The mammalian FXYD family maintains Na+ and K+ gradients between the intracellular and extracellular milieus of cells in processes such as renal Na+-reabsorption, muscle contraction and neuronal excitability. FXYDs are single-span membrane proteins that share a 35 amino acid signature domain, beginning with the sequence PFXYD and containing seven invariant and six conserved amino acids. Members of the FXYD family include FXYD1 (PLM, phospholemman), FXYD2 (the g subunit of the Na+/K+-ATPase), FXYD3 (Mat8, mammary tumor protein), FXYD4 (CHIF) and FXYD5 (RIC). FXYD6 is expressed in various epithelial cells bordering the endolymph space and in the auditory neurons. FXYD6 co-localizes with Na+/K+-ATPase in the stria vascularis and can be co-immunoprecipitated with Na+/K+-ATPase. After expression, FXYD6 associates with Na+/K+-ATPase alpha1-beta1 and alpha1-beta2 isozymes, which are preferentially expressed in different regions of the inner ear and also with gastric and non-gastric H+/K+-ATPase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12371R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12371R-FITC
Lokale Artikelnummer::
BOSSBS-12371R-FITC
Beschreibung:
Mig-2 recruits migfilin to cell-matrix adhesions, while the interaction with filamin mediates the association of migfilin with actin filaments. Together, Mig-2, migfilin and filamin define a connection between cell matrix adhesions and the actin cytoskeleton and participate in the orchestration of actin assembly and cell shape modulation. Mig-2 expression is transcriptionally elevated in leiomyomas and could be involved in its hormone-mediated growth of leiomyomas of the uterus. Expression of Mig-2 is ubiquitous, and it is found in numerous tumor tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9456R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9456R-CY3
Lokale Artikelnummer::
BOSSBS-9456R-CY3
Beschreibung:
NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4145R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4145R-A647
Lokale Artikelnummer::
BOSSBS-4145R-A647
Beschreibung:
May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3729R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3729R-CY5.5
Lokale Artikelnummer::
BOSSBS-3729R-CY5.5
Beschreibung:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0669R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0669R-CY5
Lokale Artikelnummer::
BOSSBS-0669R-CY5
Beschreibung:
May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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