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Proteine und Peptide
Artikel-Nr:
(PRSI3247P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3247P
Lokale Artikelnummer::
PRSI3247P
Beschreibung:
TRIM5 alpha peptide is used for blocking the activity of the TRIM5 alpha antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-065)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-065
Lokale Artikelnummer::
PRSI92-065
Beschreibung:
Protein-Arginine Deiminase Type-4 (PADI4) belongs to the Protein Arginine Deiminase family. PADI4 is expressed in eosinophils and neutrophils, but it is not expressed in peripheral monocytes or lymphocytes. PADI4 catalyzes the citrullination/deimination of arginine residues of proteins. In addition, PADI4 may play an important role in tumourigenesis. Genetic variations in PADI4 are a cause of susceptibility to rheumatoid arthritis (RA), which is a systemic inflammatory disease with autoimmune features and a complex genetic component.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-315)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-315
Lokale Artikelnummer::
PRSI90-315
Beschreibung:
Cochlin is an extracellular matrix protein expressed in the cochlea and vestibule of the inner ear. Mutations in the cochlin gene are linked to the autosomal-dominant DFNA9 syndrome, a disorder characterised by hearing loss. Cochlin is also expressed in follicular dendritic cells of the spleen and the lymph nodes. The N-terminus of cochlin contains a LCCL domain also present in Factor C, a serine protease of the horseshoe crab Limulus, involved in activating the coagulation cascade in response to LPS. A recent study showed that in response to inflammation, LPS or bacterial infection, cochlin is cleaved by the proteases aggrecanases and secreted into blood circulation. The secreted cochlin (LCCL domain) seems to have a role in local cytokine production, recruitment of immune effector cells and bacterial clearance. Cochlin is secreted as two forms p8 and p18, whereas p18 being the glycosylated form of p8.
VE:
1 * 10 µG
Artikel-Nr:
(BSENPE-1750-1000)
Lieferant:
Biosensis
Hersteller-Artikelnummer::
PE-1750-1000
Lokale Artikelnummer::
BSENPE-1750-1000
Beschreibung:
A proprietary preparation of human amyloid beta peptide (amino acids 1-42) that was initially monomerized by HFIP-treatment and then allowed to form oligomers by the procedure described in Youmans KL et al., 2012, followed by lyophilisation using Biosensis’ proprietary stabilization procedures.
The resulting oligomeric mixture has been specially designed to allow the formation of stable, oligomeric Aβ1-42 peptide, multimeric complexes or oligomers. The material is intended to be used as a stable and consistent standard or positive control for oligomeric ELISA assays, as well as other research applications. This product is supplied as 2 x 500 ng vials, each containing lyophilized Aβ oligomers. Note that the amount of provided oligomeric protein is based on the amount of monomeric Aβ used to form these oligomers. The precise formation, size and number of oligomers cannot be quantified by any known method.
VE:
1 * 1 µG
Artikel-Nr:
(PRSI91-479)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-479
Lokale Artikelnummer::
PRSI91-479
Beschreibung:
Plexin Domain-Containing Protein 1 (PLXDC1) is a single-pass type I membrane protein that belongs to the plexin family. Secreted PLXDC1 is localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells. PLXDC1 is expressed in fibrovascular membrane with increased expression in individuals with proliferative diabetic retinopathy. It can detect in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. PLXDC1 interacts with NID1 and may also interact with CTTN. It plays a important role in endothelial cell capillary morphogenesis, the proliferation and maintenance of neovascular endothelial cells in the formation of fibrovascular membranes (FVMs).
VE:
1 * 50 µG
Artikel-Nr:
(734-1098)
Lieferant:
Corning
Hersteller-Artikelnummer::
354232
Lokale Artikelnummer::
BDAA354232
Beschreibung:
Laminin, ein Hauptbestandteil der Basalmembran, besitzt eine Vielzahl biologischer Aktivitätsfunktionen, einschließlich Verbesserung von Adhäsion, Migration, Wachstum, Differenzierung und Neuritauswuchs von Zellen. Es kann als dünne Schicht auf die Gewebekulturoberflächen aufgetragen werden oder Nährmedien als löslicher Zusatzstoff hinzugefügt werden. Der hochkonzentrierte Laminin/Entactin-Komplex ist eine spezielle Zusammensetzung, der für dreidimensionale (3D) Nährmedien entwickelt wurde.
VE:
1 * 1 mg
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Vascular endothelial growth factor-A (VEGF-A) is produced by a wide variety of cell types, including tumor and vascular cells. VEGF-A is a mediator of vascular growth, vascular permeability, and plays a role in stimulating vasodilation via nitric oxide-dependent pathways. VEGF-A has several alternatively spliced isoforms, with VEGF-165 being the most abundant. The VEGF-165 isoform is a secreted protein that acts on receptors VEGFR-1 and VEGFR-2 to modulate endothelial cell proliferation and angiogenesis.
Artikel-Nr:
(PRSI91-575)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-575
Lokale Artikelnummer::
PRSI91-575
Beschreibung:
Mouse Leukemia inhibitory factor（lif）is a secreted protein which belongs to the LIF/OSM family.LIF has been implicated in a many physiological processes including development, hematopoiesis, bone metabolism, and inflammation. it has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6909P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6909P
Lokale Artikelnummer::
PRSI6909P
Beschreibung:
BMP15 peptide is used for blocking the activity of BMP15 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-056)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-056
Lokale Artikelnummer::
PRSI90-056
Beschreibung:
ANGPTL7 (Angiopoietin-like protein 7) is expressed in various tissues and regulates angiogenesis. Human ANGPTL7 was characterised as a potent target gene of the WNT/beta-catenin signalling pathway, and is a pharmacogenomics target in the fields of oncology and regenerative medicine. Overexpression of ANGPTL7 increases collagen expression and might exert a pathogenic role in glaucoma.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5397P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5397P
Lokale Artikelnummer::
PRSI5397P
Beschreibung:
Prosapip2 peptide is used for blocking the activity of Prosapip2 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3739P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3739P
Lokale Artikelnummer::
PRSI3739P
Beschreibung:
TLR9 peptide is used for blocking the activity of TLR9 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-646)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-646
Lokale Artikelnummer::
PRSI92-646
Beschreibung:
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumour immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Prolactin is a hormone that is produced and secreted by the pituitary gland. Prolactin acts in an endocrine, paracrine, and autocrine manner. The prolactin receptor (PRLR) is expressed on many cell types, including cells of the reproductive organs, central nervous system, and breast cancer. Prolactin signal transduction occurs via JAK kinase signaling pathways. The primary function of prolactin is to regulate lactation, but prolactin also plays functional roles in the immune system and during cell growth, apoptosis, and differentiation.
Artikel-Nr:
(PRSI92-580)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-580
Lokale Artikelnummer::
PRSI92-580
Beschreibung:
Kallikrein7, also named as stratum corneum chymotryptic enzyme (SCCE), is a secreted protein of the Kallikrein-related peptidase (KLK) family. This family contains fifteen homologous secreted serine endopeptidases and plays a significant role in various physiological processes, including skin desquamation, semen liquefaction, neural plasticity, and body fluid homeostasis. In skin KLK5, KLK 7 and KLK14 are able to degrade corneodesmosomes, which leads to desquamation of skin surface cells. KLK activation is believed to be mediated through highly organised proteolytic cascades, regulated through a series of feedback loops, inhibitors, auto-degradation and internal cleavages. Studies have shown that one potential physiological activator for KLK7 is KLK5. Along with KLK14, these three kallikreins form a proteolytic cascade in the stratum corneum. KLK7 is primarily expressed in the skin but is also detected at relatively high levels in oesophagus, heart, liver, central nervous system, kidney, pancreas, mammary and salivary glands.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-273)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-273
Lokale Artikelnummer::
PRSI90-273
Beschreibung:
APRIL is a cytokine that belongs to the TNF superfamily and binds to TACI and BCMA. It is implicated in the regulation of tumour cell growth, is involved in monocyte/macrophage-mediated immunological processes and functions as an important survival factor for plasma blasts and bone marrow plasma cells. MultimericAPRIL™ is a high activity construct in which two trimeric APRIL ligands are artificially linked via the collagen domain of ACRP30. This construct very effectively stimulates proliferation B cell. A basic amino acid sequence (QKQKKQ) close to the N-terminus of APRIL is required for binding to negatively charged sulphated glycosaminoglycan side chains of proteoglycans. Proteoglycans mediate binding of APRIL to tumour cells as well as primary lymphoid cells.
VE:
1 * 10 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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