Suche >
6-Chloro-4-methoxypyridazin-3-amine
Drucken
Sie suchten nach:
27 269 results were found
6-Chloro-4-methoxypyridazin-3-amine
Artikel-Nr:
(635-0626)
Lieferant:
ATAGO
Hersteller-Artikelnummer::
3486
Lokale Artikelnummer::
ATAG3486
Beschreibung:
Digitale Refraktometer im Taschenformat zum Messen verschiedener Parameter.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-5566R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5566R-A750
Lokale Artikelnummer::
BOSSBS-5566R-A750
Beschreibung:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at 'Ser-180', which results in the alteration of BTK plasma membrane localisation and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage: in case of oxidative conditions, specifically phosphorylates 'Ser-36' of isoform p66Shc of SHC1, leading to mitochondrial accumulation of p66Shc, where p66Shc acts as a reactive oxygen species producer. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of 'Thr-6' of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 'Lys-4' (H3K4me) by LSD1/KDM1A. In insulin signaling, may function downstream of IRS1 in muscle cells and mediate insulin-dependent DNA synthesis through the RAF1-MAPK/ERK signaling cascade. May participate in the regulation of glucose transport in adipocytes by negatively modulating the insulin-stimulated translocation of the glucose transporter SLC2A4/GLUT4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11427R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11427R-A350
Lokale Artikelnummer::
BOSSBS-11427R-A350
Beschreibung:
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include the SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes, and including the human proteins Srb7, Med6 (also designated DRIP33) and Med7 (also designated DRIP34) (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Med6 and Med7, as well as other components of SMCC, associate with coactivator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation (4,5). Additionally, SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity (6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11698R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11698R-CY7
Lokale Artikelnummer::
BOSSBS-11698R-CY7
Beschreibung:
Huntingtin yeast partner E is a 458 amino acid single-pass membrane protein. HYPE is thought to interact with Huntingtin, a protein which induces neurodegeneration when mutated. HYPE also contains two tetratricopeptide repeats (TPR), which may be involved in protein-protein interaction. The gene that encodes HYPE is located on chromosome 12, which encodes over 1,100 genes within 132 million bases and makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11427R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11427R-HRP
Lokale Artikelnummer::
BOSSBS-11427R-HRP
Beschreibung:
In mammalian cells, transcription is regulated in part by high molecular weight coactivating complexes that mediate signals between transcriptional activators and RNA polymerase (1). These complexes include the SMCC (SRB and MED protein cofactor complex), which consists of various subunits that share homology with several components of the yeast transcriptional mediator complexes, and including the human proteins Srb7, Med6 (also designated DRIP33) and Med7 (also designated DRIP34) (2,3). SMCC associates with the RNAPII (RNA polymerase II) holoenzyme through Srb7 and, in turn, enhances gene-specific activation or repression induced by DNA-binding transcription factors (4). Med6 and Med7, as well as other components of SMCC, associate with coactivator proteins from the TRAP (thyroid hormone receptor-activating protein) complex and DRIP (for vitamin D receptor interacting protein) complex to facilitate steroid receptor dependent transcriptional activation (4,5). Additionally, SMCC associates with PC4 (positive cofactor 4) to repress basal transcription independent of RNAPII activity (6).
VE:
1 * 100 µl
Lieferant:
WTW
Beschreibung:
Thermoreactors for the determination of COD, total nitrogen or total phosphorus, ensure complete digestion of the sample and maintain the necessary high reaction temperature throughout the defined period. The most important temperatures and digestion times are stored in 8 fixed, easily selectable digestion programmes. CR 3200 and CR 4200 can be used with optional TFK CR external temperature probe, which can be used as a testing aid. It can be plugged into the interface in place of a cuvette, the set and actual temperatures can be output to either a printer or a PC, so function can not only be monitored, but also documented. Suitable for 16 mm cuvettes.
Lieferant:
DWK Life Sciences
Beschreibung:
Flaschenaufsatzfilter, PBT-Verschluss, 45 mm, mit 39 mm Öffnung
Artikel-Nr:
(631-0866)
Lieferant:
GLASWARENFABRIK KARL HECHT
Hersteller-Artikelnummer::
41238020
Lokale Artikelnummer::
HECH41238020
Beschreibung:
Fließpapier 25 Blatt/Packung
VE:
1 * 25 ST
Artikel-Nr:
(COWI016.1002.5.2)
Lieferant:
COWIE
Hersteller-Artikelnummer::
016.1002.5.2
Lokale Artikelnummer::
COWI016.1002.5.2
Beschreibung:
L-shaped right angle connectors, made of PTFE, for tubings.
VE:
1 * 1 ST
Lieferant:
DWK Life Sciences
Beschreibung:
PP, coloured.
Lieferant:
MACHEREY-NAGEL
Beschreibung:
CHROMABOND® C18 ec ist eine endcapped, octadecylmodifizierte Silicaphase für SPE.
Artikel-Nr:
(114-4629)
Lieferant:
ATLAS - the shoe company
Hersteller-Artikelnummer::
45136
Lokale Artikelnummer::
ATLA45136
Beschreibung:
Sicherheitsschuh aus waserdichtem Leder, Reflektoren und einer MPU® Light-Sohle (3,5 mm Profil, öl-, säure- und benzinbeständig, antistatisch).
VE:
1 * 1 PAAR
Artikel-Nr:
(BRND115356)
Lieferant:
Brand
Hersteller-Artikelnummer::
115356
Lokale Artikelnummer::
BRND115356
Beschreibung:
PP, durchscheinend.
VE:
1 * 10 ST
Lieferant:
Brand
Beschreibung:
Borosilikatglas 3.3.
Artikel-Nr:
(519-5001)
Lieferant:
KARTELL
Hersteller-Artikelnummer::
835
Lokale Artikelnummer::
KART835
Beschreibung:
Siebeinlagen aus PE-HD. Einlage zwischen Filterpapier und Büchnertrichter, hilft Verstopfungen zu verhindern.
VE:
1 * 10 ST
Artikel-Nr:
(232-4152)
Lieferant:
USBECK Laborgeräte
Hersteller-Artikelnummer::
4120
Lokale Artikelnummer::
USBE4120
Beschreibung:
Flask tongs made from stainless steel, with vinyl coated jaws.
VE:
1 * 1 ST
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
Dieses Produkt wurde von Ihrer Organisation gesperrt. Bitte kontaktieren Sie Ihren Einkauf für weitere Informationen.
Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
Dieses Produkt ist nicht mehr verfügbar. Bitte kontaktieren Sie den VWR Kundenservice.
|
|||||||||
Listenansicht
