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2-Bromo-4-chloro-5-fluorobenzoic+acid


23 430  results were found

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Lieferant:  Bioss
Hersteller-Artikelnummer:: BS-4938R-A647
Lokale Artikelnummer:: BOSSBS-4938R-A647
Beschreibung:   Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
VE:  1 * 100 µl

Lieferant:  Bioss
Hersteller-Artikelnummer:: BS-4938R-A488
Lokale Artikelnummer:: BOSSBS-4938R-A488
Beschreibung:   Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation.
VE:  1 * 100 µl
Lieferant:  ANSELL HEALTH CARE
Beschreibung:   Superior breathable microporous laminate technology, offering Type 5/6 protection.
Lieferant:  EHRENSTORFER
Hersteller-Artikelnummer:: C16355000
Lokale Artikelnummer:: EHERC16355000
Beschreibung:   Organic Standard, Promethazinhydrochlorid
VE:  1 * 0,25 g

Lieferant:  Portwest Clothing
Hersteller-Artikelnummer:: ST44WHR
Lokale Artikelnummer:: PRTWST44WHR
Beschreibung:   These protective overshoes are designed for use in all work environments where shoes or floors need protecting. Elastic finish to top of shoe ensures a secure fit.
VE:  1 * 200 ST
Lieferant:  Bollé Safety
Beschreibung:   Überbrillen (OTG) bieten hervorragenden Schutz für Träger von Korrekturbrillen. Mit verstellbarer Kordel geliefert.
Lieferant:  Thermo Scientific
Hersteller-Artikelnummer:: 438020010
Lokale Artikelnummer:: ACRO438020010
Beschreibung:   tert-Butyl-2-amino-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate 97%
VE:  1 * 1 g

Lieferant:  UVEX
Hersteller-Artikelnummer:: 9169.164
Lokale Artikelnummer:: UVEX9169.164
Beschreibung:   Lightweight overspecs with panoramic lens with integrated side protection for optimum eye coverage.
VE:  1 * 1 ST
Lieferant:  Alfa Aesar
Beschreibung:   A synthetic intermediate and a cell-permeable autophagic sequestration blocker that protects cerebellar granule cells from apoptosis post serum/potassium deprivation.
Artikel-Nr: (PRTWPW14CLR)

Lieferant:  Portwest Clothing
Hersteller-Artikelnummer:: PW14CLR
Lokale Artikelnummer:: PRTWPW14CLR
Beschreibung:   Superleichte und strapazierfähige Sicherheitsbrille in einem schlanken Design und gekrümmtem Glas mit 10er Basiskurve.
VE:  1 * 1 ST
Lieferant:  BIONET RESEARCH
Beschreibung:   1-[(Ammoniooxy)methyl]-4-(trifluormethyl)benzolchlorid
Lieferant:  UVEX
Beschreibung:   Maximale Sicherheit durch innovatives, modernes Design: Mit ihrem x-tended eyeshield und sideshield schützt die uvex i-5 das Auge besonders zuverlässig – in jeder Situation. Durchdachte Features gewährleisten auch bei längeren Einsätzen erstklassigen Tragekomfort.
New Product
Artikel-Nr: (BOSSBS-10994R-CY5)

Lieferant:  Bioss
Hersteller-Artikelnummer:: BS-10994R-CY5
Lokale Artikelnummer:: BOSSBS-10994R-CY5
Beschreibung:   Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent on C1D.
VE:  1 * 100 µl

Lieferant:  Bioss
Hersteller-Artikelnummer:: BS-10994R-A555
Lokale Artikelnummer:: BOSSBS-10994R-A555
Beschreibung:   Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, c-myc/MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate TP53/p53 in the presence of supercoiled DNA is dependent on C1D.
VE:  1 * 100 µl
Artikel-Nr: (EIMM62259)

Lieferant:  EIMERMACHER
Hersteller-Artikelnummer:: 62259
Lokale Artikelnummer:: EIMM62259
Beschreibung:   ENZBORN® milk hand soap gently cleanses the hands and protects them from drying out.
VE:  1 * 6 ST
Lieferant:  Sigma-Aldrich
Beschreibung:   (2-Chlorethyl)diethylammoniumchlorid, Sigma-Aldrich®
Preis auf Anfrage
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das call noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das call noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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