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8H-Indeno[1,2-c]thiophen-8-one
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8H-Indeno[1,2-c]thiophen-8-one
Artikel-Nr:
(PRSI96-381)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-381
Lokale Artikelnummer::
PRSI96-381
Beschreibung:
Serpin D1 is also known as Heparin cofactor 2 (HCF2), Protease inhibitor leuserpin-2 (HLS2), Heparin cofactor II (HC-II), which belongs to the serpin family. HCF2 is expressed predominantly in liver. Thrombin inhibitor activated by the glycosaminoglycans, heparin or dermatan sulfate. In the presence of the latter, SerpinD1 / HC-II becomes the predominant thrombin inhibitor in place of antithrombin III (AT-III). In a glycosaminoglycan-independent manner, serpinD1 / HC-II also inhibits chymotrypsin. Peptides at the N-terminal of HC-II have chemotactic activity for both monocytes and neutrophils.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-5221R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5221R
Lokale Artikelnummer::
BOSSBS-5221R
Beschreibung:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5221R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5221R-CY3
Lokale Artikelnummer::
BOSSBS-5221R-CY3
Beschreibung:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified. [provided by RefSeq, May 2009].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5221R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5221R-A680
Lokale Artikelnummer::
BOSSBS-5221R-A680
Beschreibung:
This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants, some of which are disease-associated mutations, have been described for this gene, but the full-length natures of only some of these variants has been described. A related pseudogene, which is also located on chromosome 17, has been identified.
VE:
1 * 100 µl
Lieferant:
Corning
Beschreibung:
Robbins-style tips for Beckman Multimek 'Type II' systems.
Artikel-Nr:
(USBI036911)
Lieferant:
US Biological
Hersteller-Artikelnummer::
036911
Lokale Artikelnummer::
USBI036911
Beschreibung:
Anti-IGF2BP2 Rabbit Polyclonal Antibody
VE:
1 * 200 µl
Artikel-Nr:
(BNUM0057-50)
Lieferant:
Biotium
Hersteller-Artikelnummer::
BNUM0057-50
Lokale Artikelnummer::
BTIUBNUM0057-50
Beschreibung:
This MAb reacts with a 28 kDa chain of HLA-DRB1 antigen, a member of MHC class II molecules. It does not cross react with HLA-DP and HLA-DQ. The L243 antibody recognizes a different epitope than the LN3 monoclonal antibody, and these antibodies do not cross-block binding to each other's respective epitopes. HLA-DR is a heterodimeric cell surface glycoprotein comprised of a 36 kDa alpha (heavy) chain and a 28 kDa beta (light) chain. It is expressed on B-cells, activated T-cells, monocytes/macrophages, dendritic cells and other non-professional APCs. In conjunction with the CD3/TCR complex and CD4 molecules, HLA-DR is critical for efficient peptide presentation to CD4 T cells. It is an excellent histiocytic marker in paraffin sections producing intense staining. True histiocytic neoplasms are similarly positive. HLA-DR antigens also occur on a variety of epithelial cells and their corresponding neoplastic counterparts. Loss of HLA-DR expression is related to tumor microenvironment and predicts adverse outcome in diffuse large B-cell lymphoma.
VE:
1 * 50 µl
Artikel-Nr:
(ABCRAB104987.0025)
Lieferant:
ABCR
Hersteller-Artikelnummer::
AB104987.0025
Lokale Artikelnummer::
ABCRAB104987.0025
Beschreibung:
Xenondifluorid
VE:
1 * 25 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(BOSSBS-1317R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1317R-A350
Lokale Artikelnummer::
BOSSBS-1317R-A350
Beschreibung:
Signal transducer and transcription activator that mediates cellular responses to interferons (IFNs), cytokine KITLG/SCF and other cytokines and other growth factors. Following type I IFN (IFN-alpha and IFN-beta) binding to cell surface receptors, signaling via protein kinases leads to activation of Jak kinases (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize and associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of IFN-stimulated genes (ISG), which drive the cell in an antiviral state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine- and serine-phosphorylated. It then forms a homodimer termed IFN-gamma-activated factor (GAF), migrates into the nucleus and binds to the IFN gamma activated sequence (GAS) to drive the expression of the target genes, inducing a cellular antiviral state. Becomes activated in response to KITLG/SCF and KIT signaling. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11304R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11304R-A750
Lokale Artikelnummer::
BOSSBS-11304R-A750
Beschreibung:
Replication factor C (RFC) is an essential DNA polymerase accessory protein that is required for numerous aspects of DNA metabolism, including DNA replication, DNA repair and telomere metabolism. RFC is a heteropentameric complex that recognizes a primer on a template DNA, binds to a primer terminus and loads proliferating cell nuclear antigen (PCNA) onto DNA at primer-template junctions in an ATP-dependent reaction. All five of the RFC subunits share a set of related sequences (RFC boxes) that include nucleotide-binding consensus sequences. Four of the five RFC genes (including RFC1, RFC2, RFC3 and RFC4) have consensus ATP-binding motifs. The small RFC proteins, RFC2, RFC3, RFC4 and RFC5, interact with Rad24, whereas the RFC1 subunit does not. RFC1 is a substrate for caspase-3 in vitro and is cleaved by a caspase-3-like protease during FAS-mediated apoptosis. In addition, phosphorylation of the PCNA binding domain of RFC1 by Ca²⁺/calmodulin-dependent protein kinase II (CaMKII) inhibits DNA synthesis. The human RFC1 gene maps to chromosome 4p14 and encodes the RFC1 subunit.
VE:
1 * 100 µl
Artikel-Nr:
(USBI036776-BIOTIN)
Lieferant:
US Biological
Hersteller-Artikelnummer::
036776-BIOTIN
Lokale Artikelnummer::
USBI036776-BIOTIN
Beschreibung:
Anti-HSD11B2 Rabbit Polyclonal Antibody (Biotin)
VE:
1 * 200 µl
Artikel-Nr:
(PRSIXPS-1000)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
XPS-1000
Lokale Artikelnummer::
PRSIXPS-1000
Beschreibung:
Calcium/calmodulin kinase II (CaM Kinase II) is multi-functional calcium and calmodulin-dependent protein kinase that mediates cellular responses to second messengers. Phosphorylation of Thr286 produces an autonomously active form of CaM Kinase II. The antibody was raised against a synthetic phosphopeptide corresponding to amino acid residues surrounding the phosphorylated-Thr286 found in rat brain CaM Kinase II.
VE:
1 * 100 µl
Artikel-Nr:
(CHMP904670-25G)
Lieferant:
CHEMPUR
Hersteller-Artikelnummer::
904670-25G
Lokale Artikelnummer::
CHMP904670-25G
Beschreibung:
Zinkiodid ≥99,999%
VE:
1 * 25 g
Lieferant:
Bernd Kraft
Beschreibung:
Zinksulfat Heptahydrat analytisches Reagens
Lieferant:
Sigma-Aldrich
Beschreibung:
Zinkoxid, Sigma-Aldrich®
Lieferant:
Sigma-Aldrich
Beschreibung:
Zinkoxid, Sigma-Aldrich®
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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