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4,5-Dimethylpyridazine-3,6-diol
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4,5-Dimethylpyridazine-3,6-diol
Artikel-Nr:
(BOSSBS-11698R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11698R
Lokale Artikelnummer::
BOSSBS-11698R
Beschreibung:
Huntingtin yeast partner E is a 458 amino acid single-pass membrane protein. HYPE is thought to interact with Huntingtin, a protein which induces neurodegeneration when mutated. HYPE also contains two tetratricopeptide repeats (TPR), which may be involved in protein-protein interaction. The gene that encodes HYPE is located on chromosome 12, which encodes over 1,100 genes within 132 million bases and makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
VE:
1 * 100 µl
Artikel-Nr:
(FRIT50.9760.00)
Lieferant:
FRITSCH
Hersteller-Artikelnummer::
50.9760.00
Lokale Artikelnummer::
FRIT50.9760.00
Beschreibung:
Mahlbecher, Pulverisette®, Kapazität: 45 ml, Für: PULVERISETTE 7 premium, Zirkonoxid, Nutzvolumen (Probe mit Kugeln): 3 - 20 ml
VE:
1 * 1 ST
Artikel-Nr:
(BOHLH986-05)
Lieferant:
Bohlender
Hersteller-Artikelnummer::
H986-05
Lokale Artikelnummer::
BOHLH986-05
Beschreibung:
Screw cap with handy knurl, made of PTFE.
VE:
1 * 1 ST
Artikel-Nr:
(POUL10.1444-45)
Lieferant:
Poulten & Graf
Hersteller-Artikelnummer::
10.1444-45
Lokale Artikelnummer::
POUL10.1444-45
Beschreibung:
Stopfen für Messkolben, PE-LD, mit Dichtungsprofil, NS: 45/40
VE:
1 * 10 ST
Artikel-Nr:
(BOSSBS-12883R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12883R-A488
Lokale Artikelnummer::
BOSSBS-12883R-A488
Beschreibung:
The breast cancer susceptibility gene (BRCA1) localizes to chromosome 17q. Mutations within this gene account for approximately 45% of families with high incidence of breast cancer and at least 80% of families with increased incidence of both early-onset breast cancer and ovarian cancer. A second breast cancer susceptibility gene, BRCA2, located on chromosome 13q12-13, also confers a high incidence of breast cancer, but unlike BRCA1, BRCA2 does not confer a substantially elevated risk of ovarian cancer. The BRCA2-Associated Factor 35 (BRAF35) protein forms a complex with BRCA2, which associates with condensed chromatin during histone H3 phosphorylation. BRAF35 expression levels are highest in proliferating tissues and parallel BRCA2 expression patterns. The structure of BRAF35 includes a kinesin-like coiled coil domain and a nonspecific DNA binding HMG domain. The chromatin localization of BRAF35 and antibody microinjection studies indicate a role for the BRAF35/BRCA2 complex in cell cycle regulation.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Recognizes a 53 kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53. Monoclonal antibody PAb1801 does not block the binding of DO-7 MAb to p53 in an ELISA test. p53 is a tumor suppressor gene expressed in a wide variety of tissue types and is involved in regulating cell growth, replication, and apoptosis. It binds to MDM2, SV40 T antigen and human papilloma virus E6 protein. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia. Mutations involving p53 are found in a wide variety of malignant tumors, including breast, ovarian, bladder, colon, lung, and melanoma.
Artikel-Nr:
(BOSSBS-11698R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11698R-CY5
Lokale Artikelnummer::
BOSSBS-11698R-CY5
Beschreibung:
Huntingtin yeast partner E is a 458 amino acid single-pass membrane protein. HYPE is thought to interact with Huntingtin, a protein which induces neurodegeneration when mutated. HYPE also contains two tetratricopeptide repeats (TPR), which may be involved in protein-protein interaction. The gene that encodes HYPE is located on chromosome 12, which encodes over 1,100 genes within 132 million bases and makes up about 4.5% of the human genome. A number of skeletal deformities are linked to chromosome 12 including hypochondrogenesis, achondrogenesis and Kniest dysplasia. Chromosome 12 is also home to a homeobox gene cluster which encodes crucial transcription factors for morphogenesis, and the natural killer complex gene cluster encoding C-type lectin proteins which mediate the NK cell response to MHC I interaction. Trisomy 12p leads to facial development defects, seizure disorders and a host of other symptoms varying in severity depending on the extent of mosaicism and is most severe in cases of complete trisomy.
VE:
1 * 100 µl
Artikel-Nr:
(BIBB1569/16D)
Lieferant:
SciLabware
Hersteller-Artikelnummer::
1569/16D
Lokale Artikelnummer::
BIBB1569/16D
Beschreibung:
Aus PYREX®, Borosilikatglas.
VE:
1 * 1 ST
Lieferant:
BELLCO GLASS
Beschreibung:
Diese Fernbach-Kulturflaschen sind aus Borosilikatglas Typ 1, Klasse A.
Artikel-Nr:
(VITL91394)
Lieferant:
VITLAB
Hersteller-Artikelnummer::
91394
Lokale Artikelnummer::
VITL91394
Beschreibung:
Stopper for Standard Ground Joints, PP, hexagonal-knob cap, NS: 45/40, Weiß/rot
VE:
1 * 10 ST
Artikel-Nr:
(PRSI25-622)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
25-622
Lokale Artikelnummer::
PRSI25-622
Beschreibung:
Synaptojanin 1 is a phosphoinositide phosphatase that regulates levels of membrane phosphatidylinositol-4,5-bisphosphate. As such, expression of this enzyme may affect synaptic transmission and membrane trafficking.Synaptojanin-1 is a phosphatidylinositol (4,5)-bisphosphate (PI (4,5)P2) that has a role in clathrin-coated pit dynamics Perera et al. (2006) [PubMed 17158794].
VE:
1 * 50 µG
Lieferant:
Alfa Aesar
Beschreibung:
Methyl-β-cyclodextrin is used to remove cholesterol from cultured cells and to remove lipid rafts. Ideal for use in tissue and cell culture applications.
Artikel-Nr:
(SIAL674044-1L)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
674044-1L
Lokale Artikelnummer::
SIAL674044-1L
Beschreibung:
Poly(methacrylic acid, sodium salt) solution, M.W. 4000 - 6000 40% (w/w) in Wasser, Sigma-Aldrich®
VE:
1 * 1 L
Artikel-Nr:
(521-1482)
Lieferant:
Hettich
Hersteller-Artikelnummer::
1766
Lokale Artikelnummer::
HETT1766
Beschreibung:
Adapter, 1×100 ml, Ø 45×87 mm, Für: Swing-out rotor 1754, Tisch-Zentrifuge
VE:
1 * 1 ST
Artikel-Nr:
(ZEIS4255239000000)
Lieferant:
ZEISS
Hersteller-Artikelnummer::
4255239000000
Lokale Artikelnummer::
ZEIS4255239000000
Beschreibung:
Accessory for microscopes, Axio Vert, Für: A1 FL-LED, Binokularer Tubus 45°/23
VE:
1 * 1 ST
Artikel-Nr:
(216-5571)
Lieferant:
Kautex
Hersteller-Artikelnummer::
805-90464
Lokale Artikelnummer::
KAUT805-90464
Beschreibung:
Wrenches made from HDPE for opening and closing jerricans.
VE:
1 * 1 ST
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
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