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2-Amino-4-bromo-6-methylpyrimidine
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2-Amino-4-bromo-6-methylpyrimidine
Artikel-Nr:
(PRSI79-805)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-805
Lokale Artikelnummer::
PRSI79-805
Beschreibung:
In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by Chk2 gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Three transcript variants encoding different isoforms have been found for this gene.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI6423)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6423
Lokale Artikelnummer::
PRSI6423
Beschreibung:
KCNK13 Antibody: The closely related proteins KCNK13 and KCNK12 (also known as THIK1 and 2) are the first two members of a novel two pore-forming P domains K+ channels subfamily. The pore loop domain, a highly conserved region common to all potassium channels, is involved in determining potassium ion selectivity. Members of this family are all characterized by four transmembrane domains and may function to help influence the resting membrane potential of cells. KCNK13 is expressed mainly in the brain, but is also observed in kidneys. KCNK13 has been suggested to be a candidate for the Cs+-permeable K+ channel activated by GABA(B) receptors.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4459)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4459
Lokale Artikelnummer::
PRSI4459
Beschreibung:
Slitrk2 Antibody: SLIT and NTRK-like family 2 (Slitrk2) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk2 is expressed primarily in neurons in the ventricular layer of the brain. Like every other Slitrk protein except Slitrk1, overexpression of Slitrk2 inhibited neurite outgrowth in cultured neurons. Deletion analysis indicated that the functional difference between Slitrk2 and Slitrk1 is within their intracellular domains. At least two isoforms of this protein are known to exist.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI62-032)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
62-032
Lokale Artikelnummer::
PRSI62-032
Beschreibung:
For WB starting dilution is: 1:1000. For FACS starting dilution is: 1:10~50.
VE:
1 * 400 µl
New Product
Artikel-Nr:
(PRSI62-623)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
62-623
Lokale Artikelnummer::
PRSI62-623
Beschreibung:
For WB starting dilution is: 1:1000. For IHC-P starting dilution is: 1:10~50.
VE:
1 * 400 µl
New Product
Artikel-Nr:
(PRSI98-671)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
98-671
Lokale Artikelnummer::
PRSI98-671
Beschreibung:
Anti-Cd19 Mouse Monoclonal Antibody [clone: MB19-1] (APC (Allophycocyanin))
VE:
1 * 0,1 mg
New Product
Artikel-Nr:
(PRSI92-427)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-427
Lokale Artikelnummer::
PRSI92-427
Beschreibung:
Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI76-812)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-812
Lokale Artikelnummer::
PRSI76-812
Beschreibung:
The OV9A2 monoclonal antibody specifically reacts with human CD59 (Protectin), a 19-25 kDa GPI-anchored glycoprotein. CD59 is expressed on hematopoietic and non-hematopoietic cells including lymphocytes, granulocytes, erythrocytes, monocytes and neurons. CD59 can inhibit complement cytolytic activity and the assembly of the membrane attack complex when bound to C8 and C9 complement components. It is involved in T cell activation and modulates T cell adhesion through interaction with CD2.
VE:
1 * 25 Tests
New Product
Artikel-Nr:
(PRSI61-350)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
61-350
Lokale Artikelnummer::
PRSI61-350
Beschreibung:
For WB starting dilution is: 1:2000.
VE:
1 * 200 µl
New Product
Artikel-Nr:
(PRSI22-547)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
22-547
Lokale Artikelnummer::
PRSI22-547
Beschreibung:
Anti-GABPB1 Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Artikel-Nr:
(PRSI91-082)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-082
Lokale Artikelnummer::
PRSI91-082
Beschreibung:
Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. OSM encodes a growth regulator, which Inhibits the proliferation of a number of tumor cell lines. It stimulates proliferation of AIDS-KS cells. OSM regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. OSM is considered as a pleiotropic cytokine that initiates its biological activities through specific cell surface receptors. The low affinity LIF receptor that shares the similarity of containing protein gp130 has now been identified to be a component of a high- affinity OSM receptor that will transduce OSM signals. OSM has also been shown to play a role in both pro and anti-inflammatory actions. OSM may also be involved in many biometabolism processes including liver development, haematopoeisis, inflammation, bone formation and destruction and possibly CNS development.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6553P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6553P
Lokale Artikelnummer::
PRSI6553P
Beschreibung:
SPATA4 peptide is used for blocking the activity of SPATA4 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-458)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-458
Lokale Artikelnummer::
PRSI91-458
Beschreibung:
The TRK Family of Tyrosine Kinase Receptor consists of 3 members: TrkA, TrkB and TrkC. The three TRK family proteins have different ligand specificities. They connect to different neurotrophins, including NGF, BDNF, NT-3NT-4/5. TRKA binds NGF, TRKB binds BDNF and NT-3, TRKC binds NT-4/5. At the protein sequence level, human and rat TRKB have greater than 90% sequence identity and the proteins exbihit cross-species activity. TRKB is primarily expressed in the nervous system and it also expression in a wide variety of tissues with low levels.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI79-139)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-139
Lokale Artikelnummer::
PRSI79-139
Beschreibung:
Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI32-130)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
32-130
Lokale Artikelnummer::
PRSI32-130
Beschreibung:
CD3 is a component of T cell surface receptor (TCR), it cantains 5 invariable chains: gamma- , delta-, epsilon-, and zeta/eta。Clevers et al. (1988) showed the TCR/CD3 complex consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits，CD3 is responsible for the signal transduction of the TCR.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI26-371)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
26-371
Lokale Artikelnummer::
PRSI26-371
Beschreibung:
GLYATL2 belongs to the glycine N-acyltransferase family. GLYATL2 is a mitochondrial acyltransferase which transfers the acyl group to the N-terminus of glycine. It can conjugate a multitude of substrates to form a variety of N-acylglycines.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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