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Ethyl+5-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxylate
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Ethyl+5-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxylate
Lieferant:
HERAEUS
Beschreibung:
Adapter für 14×10/15-ml-Blutentnahmeröhrchen, 15×113 mm für TX-400
Artikel-Nr:
(1.14783.0001)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.14783.0001
Lokale Artikelnummer::
MERC1.14783.0001
Beschreibung:
Schnelltests, visueller Farbvergleich.
VE:
1 * 500 Tests
Artikel-Nr:
(APOSOR32705-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR32705-1G
Lokale Artikelnummer::
APOSOR32705-1G
Beschreibung:
4-Amino-2-[2-(pyridin-2-yl)ethyl]-2,3-dihydro-1H-isoindol-1-one, tech
VE:
1 * 1 g
Artikel-Nr:
(87805.180)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC87805.180
Beschreibung:
Kongorot 0,1% in Ethanol 15% (v/v) Reag. Ph. Eur. 1022001
VE:
1 * 100 mL
Artikel-Nr:
(BOSSBS-6634R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-A488
Lokale Artikelnummer::
BOSSBS-6634R-A488
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6634R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6634R-CY7
Lokale Artikelnummer::
BOSSBS-6634R-CY7
Beschreibung:
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor function: XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein intermediate complex which matures into a stable recognition complex through an intrinsic single-stranded DNA-binding activity. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Lieferant:
VWR Chemicals
Beschreibung:
Allgemein übliches Färbemittel für den Nachweis von Proteinbanden nach der Elektrophorese.
Artikel-Nr:
(APOSPC300848-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC300848-1G
Lokale Artikelnummer::
APOSPC300848-1G
Beschreibung:
2-[2-(6-Fluoroimidazo[1,2-a]pyridin-2-yl)ethyl]-1H-isoindole-1,3(2H)-dione
VE:
1 * 1 g
Artikel-Nr:
(APOSPC408027-500MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC408027-500MG
Lokale Artikelnummer::
APOSPC408027-500MG
Beschreibung:
{(S)-1-[Cyclopropyl-(4-fluoro-benzyl)-carbamoyl]-ethyl}-carbamic acid tert-butyl ester
VE:
1 * 500 mg
Artikel-Nr:
(APOSPC410485-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC410485-1G
Lokale Artikelnummer::
APOSPC410485-1G
Beschreibung:
[3-Cyclopropyl-6-(1-ethyl-1H-pyrazol-4-yl)-4-(trifluoromethyl)-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
VE:
1 * 1 g
Artikel-Nr:
(BLDPBD01151325-250)
Lieferant:
BLD PHARMATECH GMBH
Hersteller-Artikelnummer::
BD01151325-250
Lokale Artikelnummer::
BLDPBD01151325-250
Beschreibung:
10-Ethyl-3,7,8-trimethylbenzo[g]pteridine-2,4(3H,10H)-dione 97%
VE:
1 * 250 mg
Lieferant:
VWR Chemicals
Beschreibung:
Ethylmethylketon ≥99,5%, AnalaR NORMAPUR® ACS, Reag. Ph. Eur. analytisches Reagens
Lieferant:
VWR Chemicals
Beschreibung:
Red Taq DNA Polymerase is a blend of Taq DNA polymerase combined with an inert red dye. The dye enables quick visual recognition of reactions to which enzyme has been added, as well as confirmation of complete mixing.
Artikel-Nr:
(PRSI29-453)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-453
Lokale Artikelnummer::
PRSI29-453
Beschreibung:
PCBP4 is a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G (2)-M.This gene encodes a member of the KH-domain protein subfamily. Proteins of this subfamily, also referred to as alpha-CPs, bind to RNA with a specificity for C-rich pyrimidine regions. Alpha-CPs play important roles in post-transcriptional activities and have different cellular distributions. This gene is induced by the p53 tumor suppressor, and the encoded protein can suppress cell proliferation by inducing apoptosis and cell cycle arrest in G (2)-M. This gene's protein is found in the cytoplasm, yet it lacks the nuclear localization signals found in other subfamily members. Multiple alternatively spliced transcript variants have been described, but the full-length nature for only some has been determined.
VE:
1 * 50 µG
Lieferant:
Merck
Beschreibung:
Glutaraldehyd 25% in wässriger Lösung für die Elektronenmikroskopie, Sigma-Aldrich®
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Ethyl 2-(6-oxo-8-(trifluoromethyl)pyrimido[2,1-b][1,3,5]thiadiazin-3(2H,4H,6H)-yl)acetate
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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