Sie suchten nach: K+LINE+LOGISTIS+(USA)+INC

Artikel-Nr: (PRSI5021)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 5021

Lokale Artikelnummer:: PRSI5021

Beschreibung: TTBK2 Antibody: Tau tubulin kinase (TTBK2) is a serine/threonine kinase whose substrates are thought to include the tau and tubulin proteins. Mutations in the TTBK2 gene cause spinocerebellar ataxia type 11 (SCA11), a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. Recent studies have shown that increased levels of TTBK2 expression in kidney carcinoma and melanoma cell lines increases resistance to the chemotherapeutic agent Sunitinib, and that reduction of TTBK2 though the use of siRNA sensitized these cell lines to the effects of Sunitib, suggesting that TTBK2 can be used as a resistance marker as well a potential target to overcome resistance.

VE: 1 * 100 µG

Sale

Artikel-Nr: (PRSI76-950)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 76-950

Lokale Artikelnummer:: PRSI76-950

Beschreibung: The mT2.7 monoclonal antibody specifically reacts with mouse CD282, the Toll-like receptor 2 (TLR2). It is a type I transmembrane signaling receptor containing IL-1 receptor like intracellular domain and leucine-rich repeats (LRR) in the extracellular domain. CD282 is expressed on monocytes, macrophages, dendritic cells, and the RAW264.7 cell line and is involved distinguishing bacterial lipoproteins.

VE: 1 * 0,1 mg

New Product Sale

Artikel-Nr: (PRSIXP-5230)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: XP-5230

Lokale Artikelnummer:: PRSIXP-5230

Beschreibung: Midkine exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Its expression is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines.

VE: 1 * 100 µG

Sale

Artikel-Nr: (PRSI91-936)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 91-936

Lokale Artikelnummer:: PRSI91-936

Beschreibung: emaphorin-3A is a secreted protein which belongs to the semaphorin family. Semaphorins are a family of secreted and cell-bound signaling molecules defined by the presence of a common 500 aa Sema domain.This protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines.

VE: 1 * 50 µG

Sale

Artikel-Nr: (PRSI28-096)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 28-096

Lokale Artikelnummer:: PRSI28-096

Beschreibung: The protein encoded by TRIM68 contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. TRIM68 is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. TRIM68 was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.

VE: 1 * 100 µG

Sale

Artikel-Nr: (PRSI28-097)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 28-097

Lokale Artikelnummer:: PRSI28-097

Beschreibung: The protein encoded by the TRIM68 gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. TRIM68 is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.

VE: 1 * 50 µG

Sale

Artikel-Nr: (PRSI25-386)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 25-386

Lokale Artikelnummer:: PRSI25-386

Beschreibung: ZNF146 (OZF) overexpression in tumours may alter the balance between hRap1 and other telomeric proteins; therefore OZF function may be linked to telomere regulation. ZNF146 is strongly overexpressed in many pancreas and colorectal cancers. Increased gene copy numbers are detected in 3 of 12 tumor cell lines and 2 of 12 primary pancreatic carcinomas. ZNF146 is overexpresseed in 80% of colorectal cancers.

VE: 1 * 50 µG

Sale

Artikel-Nr: (PRSIXW-7891)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: XW-7891

Lokale Artikelnummer:: PRSIXW-7891

Beschreibung: FUNCTION: Activates NF-κ-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
SUBUNIT: CARD14 and BCL10 bind to each other by CARD-CARD interaction.
SIMILARITY: Contains 1 PDZ (DHR) domain.
SUBCELLULAR LOCATION: Cytoplasm.
TISSUE SPECIFICITY: Expressed in placenta. Also detected in HeLa S3 cells, but not in the other cancer cell lines tested.

VE: 1 * 50 µG

Sale

Artikel-Nr: (PRSI79-673)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 79-673

Lokale Artikelnummer:: PRSI79-673

Beschreibung: Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.

VE: 1 * 100 µG

Sale

Artikel-Nr: (PRSI92-221)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-221

Lokale Artikelnummer:: PRSI92-221

Beschreibung: EIF5A2 is a member of the eIF-5A family. It is a 153 amino acids protein that in humans is encoded by the EIF5A2 gene. EIF5A2 is expressed in ovarian and colorectal cancer cell lines and highly expressed in testis.It has an important function at the level of mRNA turnover and mediates effects of polyamines on neuronal process extension and survival. It plays an important role in brain development and function, and in skeletal muscle stem cell differentiation.

VE: 1 * 50 µG

Sale

Artikel-Nr: (PRSIXP-5230BT)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: XP-5230BT

Lokale Artikelnummer:: PRSIXP-5230BT

Beschreibung: Midkine exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Its expression is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines.

VE: 1 * 50 µG

Sale

Artikel-Nr: (PRSI92-638)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-638

Lokale Artikelnummer:: PRSI92-638

Beschreibung: Limitin, also called IFN-ζ, is a secreted interferon (IFN)-like glycoprotein. Limitin has approximately 30% sequence homology with IFN- alpha, IFN- beta , and IFN-ω and binds to the IFN- alpha/ beta receptors. Like IFN- alpha and IFN- beta , limitin has antiproliferative, immunomodulatory, and antiviral properties, it is unique in lacking influence on myeloid and erythroid progenitors. Similar dose requirement between limitin and IFN- alpha was observed for the enhancement of cytotoxic T lymphocyte activity, the augmentation of MHC class I expression, and the growth inhibition of a myelomonocytic leukaemia cell line.

VE: 1 * 50 µG

Sale

Artikel-Nr: (PRSI34-132)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 34-132

Lokale Artikelnummer:: PRSI34-132

Beschreibung: Recognises 78 kDa moesin protein. Moesin, a member of the Talin-4.1 superfamily, is a linking protein of the submembraneous actin cytoskeleton. It is expressed in variable amounts in cells of different phenotypes such as macrophages, lymphocytes, fibroblastic, endothelial, epithelial, and neuronal cell lines but not in blood cells. The ERM proteins, ezrin, radixin, and moesin are involved in a variety of cellular functions, such as cell adhesion, migration, and the organization of cell surface structures, and are highly homologous, both in protein sequence and in functional activity, with merlin/schwannomin, a neurofibromatosis-2-associated tumor-suppressor protein. Cell lines of epithelial and mesothelial origin contain both moesin and radixin whereas cells of endothelial and lymphoid origin express moesin.

VE: 1 * 100 µG

New Product Sale

Artikel-Nr: (PRSI92-446)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 92-446

Lokale Artikelnummer:: PRSI92-446

Beschreibung: Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterised as a growth factorthat can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by anumber of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cellsand fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophageprogenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. Onmature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on nonhematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF canalso stimulate the proliferation of a number of tumour cell lines, including osteogenic sarcoma, carcinoma andadenocarcinoma cell lines.

VE: 1 * 50 µG

Sale

Artikel-Nr: (PRSI90-389)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 90-389

Lokale Artikelnummer:: PRSI90-389

Beschreibung: CCL24 (eotaxin-2) has been shown to induce chemotaxis of eosinophils, basophils and resting T lymphocytes but not monocytes and activated T lymphocytes. CCL24 is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. CCL24 interacts with chemokine receptor CCR3 to induce chemotaxis in eosinophils. Elevated levels of CCL24 has been seen in patients with aspirin-exacerbated respiratory disease (AERD), such as asthma.

VE: 1 * 50 µG

Sale

Artikel-Nr: (PRSI29-589)

Lieferant: ProSci Inc.

Hersteller-Artikelnummer:: 29-589

Lokale Artikelnummer:: PRSI29-589

Beschreibung: Many breast, pancreatic, colonic and non-small-cell lung carcinoma lines express CEACAM6 and CEACAM5, and antibodies to both can affect tumor cell growth in vitro and in vivo. CEACAM6 expression is elevated in many solid tumors, but variable as a function of histotype. It may be a promising target for antibody-based therapy.

VE: 1 * 100 µG

Sale