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L(-)-Glutathion+(oxidierte+Form)
Artikel-Nr:
(BOSSBS-2633R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2633R-A750
Lokale Artikelnummer::
BOSSBS-2633R-A750
Beschreibung:
Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury. In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets. This form is rapidely lost upon angiogenic or proinflammatory activation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11017R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11017R-A350
Lokale Artikelnummer::
BOSSBS-11017R-A350
Beschreibung:
Long pentraxins are a family of highly conserved proteins that are expressed in the brain and central nervous system, and form multimeric complexes. Neuronal pentraxin 1 (NP1), NP2, and neuronal pentraxin receptor (NPR) are members of the long pentraxins that represent a neuronal uptake pathway that may function during synapse formation and remodeling. The NP1 gene is located on chromosome 17q25.3 and the protein product mediates the uptake of synaptic material, including the presynaptic snake venom toxin, taipoxin (3). NP2, whose function is unknown, is located on chromosome 7q22.1 and like NP1 contains several potential N-linked glycosylation sites. NPR is expressed on the cell membrane and can form heteropentamers with NP1 and NP2 that can be released from the cell membrane by proteolysis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13179R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13179R
Lokale Artikelnummer::
BOSSBS-13179R
Beschreibung:
FKBP8 is an immunophilin family member lacking PPIase/arotamase activity that influences immunoregulation, protein folding and trafficking in neurons associated with memory function. The FKBPr38 form derives from a truncated ORF. Presenilin 1 and 2 form molecular complexes withæ¢nd promote degradation ofæ¡KBPr38, and Bcl-2, and sequester these proteins in ER/Golgi, thereby inhibiting FKBPr38-mediated, ?secretase-independent, mitochondrial targeting of Bcl-2. FKBP8 present in the central nervous system can antagonize hedgehog (HH) signaling, where HH is critical for patterning and growth of many tissues in the developing embryo. Mouse FKBPr38 mRNA is present in neurons and glial cells and appears more pronounced in neurons associated with the hippocampal formation in adult mouse brains.
VE:
1 * 100 µl
Lieferant:
Biotium
Beschreibung:
Recognizes a protein of 12 kDa, identified as microglobulin. Major histocompatibility complex (MHC) class 1 molecules bind to antigens for presentation on the surface of cells. The proteasome is responsible for producing these antigens from the components of foreign pathogens. MHC class 1 molecules consist of an α heavy chain that contains three subdomains (α1, α2, α3) and a non-covalent associating light chain, known as β-2-Microglobulin. β-2-Microglobulin associates with the α3 subdomain of the α heavy chain and forms an immunoglobulin domain-like structure that mediates proper folding and expression of MHC class 1 molecules. The α1 and α2 domains of the α heavy chain form the peptide antigen-binding cleft. Mutations in the β-2-Microglobulin gene can enhance the progression of malignant melanoma phenotypes.
Artikel-Nr:
(BOSSBS-9010R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9010R-CY5
Lokale Artikelnummer::
BOSSBS-9010R-CY5
Beschreibung:
DPP6 is a Type-II serine proteinase of the clan SC. The clan SC proteinases have a catalytic triad of Ser-Asp-His, and like other Serine proteinases, the active site serine is in a Gly-Xaa-Ser-Xaa -Gly orientation. DPP6 has an Asp instead of Ser in the catalytic site. DPP6 is a member of a broader family of dipeptidyl peptidases including DPP4, FAP/Seprase, DPP2, DPP8, DPP9, DPP10, which have differing substrate specificity and tissue localizations. The surface-bound DPP6 is a homodimer, and cleavage of in the stalk region releases a shed form of DPP6. The shed is the form found in serum. DPP6 has been found in highest abundance in the brain, but also in the kidney, liver and lung.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11087R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11087R-CY5
Lokale Artikelnummer::
BOSSBS-11087R-CY5
Beschreibung:
LRFN2 is a 789 amino acid single-pass type I membrane protein belonging to the LRFN family. Encoded by a gene that maps to human chromosome 6p21.2, LRFN2 is moderately expressed in brain, spleen and testis. LRFN2 contains one fibronectin type-III domain, one Ig-like (immunoglobulin-like) domain and six LRR (leucine-rich) repeats. LRFN2 promotes neurite outgrowth in hippocampal neurons, enhances cell surface expression of two NMDA receptor subunits, NMDAΩ1 and NMDAé1, and may play a role in redistributing PSD-95 to cell periphery. LRFN2 forms heteromeric complexes with LRFN1, LRFN3, LRFN4 and LRFN5, and is capable of forming homomeric complexes, but not across cell junctions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12142R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12142R-FITC
Lokale Artikelnummer::
BOSSBS-12142R-FITC
Beschreibung:
The membranes of myelinating Schwann cells are joined by tight, gap and adherens junctions, all of which are found in regions of noncompact myelin: the paranodal loops, incisures of Schmidt-Lanterman and mesaxons. Tight junctions help establish polarity in mammalian epithelia by forming a physical barrier that separates apical and basolateral membranes. Pals-associated tight junction protein (PATJ), the human homolog of Drosophila Discs Lost, is differentially localized in myelinating Schwann cells. PATJ associates with Claudin-1, CRB1 (a transmembrane protein that plays a role in epithelial cell polarity and photoreceptor development), and Pals1 (a Lin-7 associated protein). The PATJ/Pals1/CRB1 complex can form a tripartite tight junction in epithelial cells crucial to their integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11190R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11190R-A488
Lokale Artikelnummer::
BOSSBS-11190R-A488
Beschreibung:
C9 is a plasma protein synthesized in the liver and monocytes consisting of a single polypeptide chain. C9 is a part of the membrane attack complex (MAC), an important component of the immune system. The MAC forms upon complement system activation by invading pathogenic bacteria and consists of the four major complement proteins: C5b, C6, C7 and C8. These complement proteins bind to the outer surface of the plasma membrane of the invading cell. C9 binds to the membrane associated C5b-8 protein, which leads to the circular polymerization of 12-18 C9 molecules. These polymerized C9 molecules form a ring structure in the membrane. Molecules can then diffuse freely through this transmembrane channel, causing cell lysis and destruction of the invading bacterial cell.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5089R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5089R-HRP
Lokale Artikelnummer::
BOSSBS-5089R-HRP
Beschreibung:
Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2723R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2723R-A750
Lokale Artikelnummer::
BOSSBS-2723R-A750
Beschreibung:
May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7799R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7799R-HRP
Lokale Artikelnummer::
BOSSBS-7799R-HRP
Beschreibung:
The product of the GAJ gene associates with HOP2 to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 and DMC1. Both the MND1 and HOP2 genes are indispensable for meiotic recombination.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9411R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9411R-A750
Lokale Artikelnummer::
BOSSBS-9411R-A750
Beschreibung:
TSPAN2 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. TSPAN2 may play a role in Signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6671R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6671R-CY7
Lokale Artikelnummer::
BOSSBS-6671R-CY7
Beschreibung:
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9411R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9411R-FITC
Lokale Artikelnummer::
BOSSBS-9411R-FITC
Beschreibung:
TSPAN2 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. TSPAN2 may play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9452R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9452R-A680
Lokale Artikelnummer::
BOSSBS-9452R-A680
Beschreibung:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9452R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9452R-FITC
Lokale Artikelnummer::
BOSSBS-9452R-FITC
Beschreibung:
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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