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6-Bromo-1H-indazole-3-carbonitrile

19 380  results were found

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Beschreibung:   Hemogen is a 484 amino acid protein encoded by the human gene HEMGN. Hemogen is a nuclear protein that is expressed in hematopoietic precursor cells and can be detected in CD34+ and K-562 leukemia cell line. It is also expressed in bone marrow, testis, thymus and thyroid tumors, non-Hodgkin lymphoma, various leukemia cell lines, peripheral blood mononuclear cells (PBMCs) and bone marrow mononuclear cells (BMMCs) of patients with leukemia. Hemogen is down-regulated during megakaryocytic differentiation of K-562 cells by 12-O-tetradecanoylphorbol-13-acetate (TPA) (at protein level). It can be up-regulated in normal PBMCs by mitogens.
Artikel-Nr: BOSSBS-12303R-HRP
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-12303R-HRP
Lokale Artikelnummer:: BOSSBS-12303R-HRP
Lieferant: Bioss



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Beschreibung:   RDH13, also known as all-trans and 9-cis retinol dehydrogenase 13 or SDR7C3, is a 331 amino acid mitochondrial protein belonging to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed, mostly in eye, pancreas, placenta and lung, RDH13 localizes on the outer side of the inner mitochondrial membrane. Related to microsomal retinoid oxidoreductase RDH11, RDH13 is considered to be a major enzyme among the RDH family of proteins. Catalytically active, RDH13 recognizes retinoids as substrates and may function in retinoic acid production. RDH13 may function to protect the mitochondria against oxidative stress. Leber congenital amaurosis (LCA) type 3, an inherited autosomal recessive retinal disease, has been associated with defects of RDH13. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
Artikel-Nr: BOSSBS-8333R-CY5
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-8333R-CY5
Lokale Artikelnummer:: BOSSBS-8333R-CY5
Lieferant: Bioss



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Beschreibung:   RDH13, also known as all-trans and 9-cis retinol dehydrogenase 13 or SDR7C3, is a 331 amino acid mitochondrial protein belonging to the short-chain dehydrogenases/reductases (SDR) family. Widely expressed, mostly in eye, pancreas, placenta and lung, RDH13 localizes on the outer side of the inner mitochondrial membrane. Related to microsomal retinoid oxidoreductase RDH11, RDH13 is considered to be a major enzyme among the RDH family of proteins. Catalytically active, RDH13 recognizes retinoids as substrates and may function in retinoic acid production. RDH13 may function to protect the mitochondria against oxidative stress. Leber congenital amaurosis (LCA) type 3, an inherited autosomal recessive retinal disease, has been associated with defects of RDH13. LCA represents the most common genetic cause of congenital visual impairment in infants and children.
Artikel-Nr: BOSSBS-8333R-CY3
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-8333R-CY3
Lokale Artikelnummer:: BOSSBS-8333R-CY3
Lieferant: Bioss



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Beschreibung:   Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
Artikel-Nr: BOSSBS-6505R-A555
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-6505R-A555
Lokale Artikelnummer:: BOSSBS-6505R-A555
Lieferant: Bioss



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Beschreibung:   Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
Artikel-Nr: BOSSBS-6505R-HRP
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-6505R-HRP
Lokale Artikelnummer:: BOSSBS-6505R-HRP
Lieferant: Bioss



Menge:
 
 
 
   
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Beschreibung:   Lipoxygenases are a family of enzymes which dioxygenate unsaturated fatty acids, thus initiating lipoperoxidation of membranes and synthesis of signaling molecules, as well as inducing structural and metabolic changes in the cell. The Lox enzymes in mammals include 12-LO and 15-LO, which are classified with respect to their positional specificity of the deoxygenation of their most common substrate, arachidonic acid. The metabolism of arachidonic acid leads to the generation of biologically active metabolites that have been implicated in cell growth and proliferation, as well as survival and apoptosis. 15-Lipoxygenase (15-LO) acts in physiological membrane remodeling and the pathogenesis of atherosclerosis, inflammation, and carcinogenesis. It is highly regulated and expressed in a tissue- and cell-type-specific fashion. IL-4 and IL-13 play important roles in transactivating the 15-LO gene. Overexpression of 15-LO type 1 in prostate cancer contributes to the cancer progression by regulating IGF-1R expression and activation.
Artikel-Nr: BOSSBS-6505R-CY7
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-6505R-CY7
Lokale Artikelnummer:: BOSSBS-6505R-CY7
Lieferant: Bioss



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Beschreibung:   7-Methoxy-2-benzofurancarbonsäure
Artikel-Nr: MAYBAC35494.250
VE: 1 * 250 mg
Hersteller-Artikelnummer:: AC35494.250
Lokale Artikelnummer:: MAYBAC35494.250
Lieferant: Thermo Scientific



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Beschreibung:   NeuroMag™ transfection reagent is the first dedicated Magnetofection™ transfection reagent for neurons from 1 DIV to 21 DIV. It has proven to be extremely efficient in transfecting a large variety of primary neurons, such as cortical, hippocampal, dorsal root ganglion and motor neurons with all types of nucleic acids.
Artikel-Nr: OZBINM50200
VE: 1 * 200 µl
Hersteller-Artikelnummer:: NM50200
Lokale Artikelnummer:: OZBINM50200
Lieferant: OZ BIOSCIENCES



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Beschreibung:   2-(4,5,6,7-Tetraiodo-1,3-dioxoisoindolin-2-yl)acetic acid
Artikel-Nr: J64414.MA
VE: 1 * 10 mg
Hersteller-Artikelnummer:: J64414.MA
Lokale Artikelnummer:: ALFAJ64414.MA
Lieferant: Alfa Aesar



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Beschreibung:   Appearance: White to tan Solid
Artikel-Nr: ACRO425740050
VE: 1 * 5 g
Hersteller-Artikelnummer:: 425740050
Lokale Artikelnummer:: ACRO425740050
Lieferant: Thermo Scientific



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Beschreibung:   7-Methoxy-2-benzofurancarbonsäure
Artikel-Nr: FLUO018775-1G
VE: 1 * 1 g
Hersteller-Artikelnummer:: 018775-1G
Lokale Artikelnummer:: FLUO018775-1G
Lieferant: FLUOROCHEM



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Beschreibung:   A gene of chromosome 6q23 encodes the 640 amino acid protein, EYA4 (eyes absent) (1). EYA is one of four members of the eyes absent family (1). A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family (1). EYA4 is expressed in the craniofacial mesenchyme, the dermamyotome, and the limb (1). The conserved region in other EYA proteins interacts with SIX, DACH, and G-proteins, which regulate transcription in early embryonic development (1,2,3,4). SIX translocates EYA1-3 to the nucleus, and G-proteins can stop this interaction (3,4). Premature stop codon mutations in EYA4 cause postlingual, progressive autosomal dominant hearing loss in humans (2). This shows that EYA4 is also vital to the mature organ of Corti (2). EYA4 may cause oculo-dento-digital syndrome, based on its expression pattern and map postion (1).
Artikel-Nr: BOSSBS-13126R-CY7
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-13126R-CY7
Lokale Artikelnummer:: BOSSBS-13126R-CY7
Lieferant: Bioss



Menge:
 
 
 
   
Image Unavailable
Beschreibung:   A gene of chromosome 6q23 encodes the 640 amino acid protein, EYA4 (eyes absent) (1). EYA is one of four members of the eyes absent family (1). A 271 amino acid domain at the carboxyl terminal is highly conserved amongst the members of the eyes absent family (1). EYA4 is expressed in the craniofacial mesenchyme, the dermamyotome, and the limb (1). The conserved region in other EYA proteins interacts with SIX, DACH, and G-proteins, which regulate transcription in early embryonic development (1,2,3,4). SIX translocates EYA1-3 to the nucleus, and G-proteins can stop this interaction (3,4). Premature stop codon mutations in EYA4 cause postlingual, progressive autosomal dominant hearing loss in humans (2). This shows that EYA4 is also vital to the mature organ of Corti (2). EYA4 may cause oculo-dento-digital syndrome, based on its expression pattern and map postion (1).
Artikel-Nr: BOSSBS-13126R-CY3
VE: 1 * 100 µl
Hersteller-Artikelnummer:: BS-13126R-CY3
Lokale Artikelnummer:: BOSSBS-13126R-CY3
Lieferant: Bioss



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Beschreibung:   1,4-Benzodioxan-6-boronsäurepinakolester
Artikel-Nr: COBBPN-8646-1G
VE: 1 * 1 g
Hersteller-Artikelnummer:: PN-8646-1G
Lokale Artikelnummer:: COBBPN-8646-1G
Lieferant: COMBI-BLOCKS



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Beschreibung:   5-Methoxy-2-benzofurancarbonsäure
Artikel-Nr: FLUO018774-1G
VE: 1 * 1 g
Hersteller-Artikelnummer:: 018774-1G
Lokale Artikelnummer:: FLUO018774-1G
Lieferant: FLUOROCHEM



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Beschreibung:   1,3-Dimethyl-1H-pyrazol-5-boronsäure
Artikel-Nr: COBBBB-6021-250M
VE: 1 * 250 mg
Hersteller-Artikelnummer:: BB-6021-250M
Lokale Artikelnummer:: COBBBB-6021-250M
Lieferant: COMBI-BLOCKS



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