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N-Cyclopropyl-5-fluoro-2-nitroaniline
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N-Cyclopropyl-5-fluoro-2-nitroaniline
Artikel-Nr:
(BOSSBS-12976R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12976R-CY7
Lokale Artikelnummer::
BOSSBS-12976R-CY7
Beschreibung:
Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.
VE:
1 * 100 µl
Lieferant:
FLUOROCHEM
Beschreibung:
2,2-Difluor-1,3-benzodioxol-5-carbonsäure
Artikel-Nr:
(212-7068)
Lieferant:
MURRAY S
Hersteller-Artikelnummer::
T103/V3T004/C
Lokale Artikelnummer::
MURRT103/V3T004/C
Beschreibung:
Die Fläschchen bestehen aus Neutralglas mit PE-Verschlussstopfen Geeignet für die verschiedensten Anwendungsmöglichkeiten in Labor, Produktion usw.
VE:
1 * 162 ST
Lieferant:
FLUOROCHEM
Beschreibung:
Methyl-2,2-difluor-2-(fluorsulfonyl)acetat
Artikel-Nr:
(1663700.)
Lieferant:
USP
Hersteller-Artikelnummer::
1663700
Lokale Artikelnummer::
USPH1663700
Beschreibung:
USP Reference Standards are specified for use in conducting official USP–NF tests and assays. USP also provides Reference Standards specified in the Food Chemicals Codex as well as authentic substances—high-quality chemical samples—as a service to analytical, clinical, pharmaceutical and research laboratories. To confirm accuracy and reproducibility, USP Reference Standards are rigorously tested and evaluated by multiple independent laboratories including USP, commercial, regulatory, and academic labs. USP also provide publicly available, official documentary standards for pharmaceutical ingredients in the USP–NF that link directly with our primary reference standards.
VE:
1 * 200 mg
Artikel-Nr:
(BOSSBS-11044R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11044R-A680
Lokale Artikelnummer::
BOSSBS-11044R-A680
Beschreibung:
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalisation motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated Signalling pathways. Involved in TGF-beta receptor Signalling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin Signalling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin Signalling. May activate non-canonical Wnt Signalling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11044R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11044R-A350
Lokale Artikelnummer::
BOSSBS-11044R-A350
Beschreibung:
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11044R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11044R-A555
Lokale Artikelnummer::
BOSSBS-11044R-A555
Beschreibung:
Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling.
VE:
1 * 100 µl
Lieferant:
Alfa Aesar
Beschreibung:
Nε-(tert-butoxycarbonyl)-Nɑ-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-lysine 98%
Lieferant:
FLUOROCHEM
Beschreibung:
2,2-Difluor-1,3-benzodioxol-4-carbaldehyd
Lieferant:
Thermo Scientific
Beschreibung:
(2,4-Dichlorphenylthio)acetonitril
Lieferant:
Jallatte
Beschreibung:
Pull-on winter boots made from AP23™ leather (oil and water repellent). It is 10 to 15% thicker than most leathers used for safety footwear (2,4 mm).
Lieferant:
SIGMA ALDRICH MICROSCOPY
Beschreibung:
This is a mounting medium (contains 45% acrylic resin and 55% xylenes) used in microscopy. It is an adhesive and specimen preservative that can be used manually and in automated coverslipping equipment. Special purpose adhesive and sealant for use with glass, non plastic and other non-reactive materials.
Artikel-Nr:
(BOSSBS-8389R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8389R-CY7
Lokale Artikelnummer::
BOSSBS-8389R-CY7
Beschreibung:
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8389R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8389R-CY5
Lokale Artikelnummer::
BOSSBS-8389R-CY5
Beschreibung:
Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110.
VE:
1 * 100 µl
Lieferant:
CEMO
Beschreibung:
These small container/laboratory trays can be combined to cover a complete storage area and also can be used as storage/filling station. Trays can be used with or without perforated plate.
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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