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cis-1,2-Cyclopentandiol
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cis-1,2-Cyclopentandiol
Artikel-Nr:
(BOSSBS-11255R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11255R-CY7
Lokale Artikelnummer::
BOSSBS-11255R-CY7
Beschreibung:
Several protein-protein interactions are essential to membrane fusion during endocytosis. Membrane fusion requires interaction among SNARE1 proteins associated with both donor and acceptor membranes (1,2). Following membrane fusion, the α-SNAP cytoplasmic adapter protein binds to the SNARE complex. N-ethylmaleimide-sensitive factor (NSF), a hexameric ATPase, then associates with the α-SNAP/SNARE complex to mediate SNARE disassembly during membrane fusion (3,4). The ATPase activity of NSF induces a conformational change in the α-SNAP/SNARE complex that leads to its dissociation from the membrane, membrane fusion and eventual recycling of the SNARE complex for subsequent membrane fusion (3,4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9988R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9988R-A750
Lokale Artikelnummer::
BOSSBS-9988R-A750
Beschreibung:
The smallest of the human chromosomes, 21 makes up about 1.5% of the human genome. Chromosome 21 contains nearly 300 genes and 47 million base pairs. Down syndrome, also known as trisomy 21, is the disease most commonly associated with chromosome 21. Alzheimer's disease, Jervell and Lange-Nielsen syndrome and amyotrophic lateral sclerosis are also associated with chromosome 21. Translocations are found to occur between chromosome 21 and 8, and chromosome 21 and 12, in certain leukaemias. C2CD2 is an 696 amino acid protein that is secreted. The C2CD2 gene product has been provisionally designated C2CD2 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12057R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12057R
Lokale Artikelnummer::
BOSSBS-12057R
Beschreibung:
eIF3K (Eukaryotic translation initiation factor 3 subunit K, Muscle-specific gene M9 protein) is a widely expressed translation initiation factor that belongs to the eIF3 subunit K family. Translation initiation factor 3 (eIF3) is a multisubunit complex containing at least 12 subunits. eIF3 binds to the 40S ribosomal subunit, promotes the binding of methionyl-tRNAi and mRNA, and interacts with several other initiation factors to form the 40S initiation complex. eIF3K is the smallest subunit of eIF3 and it interacts with several other subunits of eIF3 and the 40S ribosomal subunit. eIF3K is conserved among high eukaryotes, including mammals, insects, and plants, and it is ubiquitously expressed in human tissues. eIF3K is distributed both in nucleus and cytoplasm and colocalizes with cyclin D3, a regulatory subunit of cyclin-dependent kinase 4 (Cdk4).
VE:
1 * 100 µl
Artikel-Nr:
(SIAL375462-5G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
375462-5G
Lokale Artikelnummer::
SIAL375462-5G
Beschreibung:
3H-Benzo-1,2-dithiol-3-on, Sigma-Aldrich®
VE:
1 * 5 g
Artikel-Nr:
(SIAL460273-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
460273-1G
Lokale Artikelnummer::
SIAL460273-1G
Beschreibung:
1,2-Bis(diphenylphosphino)benzol, Sigma-Aldrich®
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-13360R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13360R
Lokale Artikelnummer::
BOSSBS-13360R
Beschreibung:
Heterotrimeric G protein-mediated signal transduction is a dynamically regulated process with the intensity of signal decreasing over time despite the continued presence of the agonist (1,2). G protein-coupled receptor kinases (GRKs) are activated by activated G protein-coupled receptors, and they function to phosphorylate and inactivate cell surface receptors in the heterotrimeric G protein signaling cascade (3,4). GIT1 (for GRK-interactor 1) and GIT2 are GTPase-activating proteins (GAP) for members of the ADP ribosylation factor (ARF) family of small GTP-binding proteins, which are involved in vesicular trafficking (5,6). GIT1 overexpression results in reduced internalization and resensitization of b2-adrenergic receptor, thus reducing b2-adrenergic receptor signaling (5).
VE:
1 * 100 µl
Lieferant:
COMBI-BLOCKS
Beschreibung:
8-Brom-6-methyl-3-nitroimidazo[1,2-a]pyridin
Lieferant:
COMBI-BLOCKS
Beschreibung:
8-Brom-6-chlorimidazo[1,2-a]pyridin-3-carbaldehyd
Artikel-Nr:
(SIAL127175-10G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
127175-10G
Lokale Artikelnummer::
SIAL127175-10G
Beschreibung:
1,2-Bis(diethylamino)methan, Sigma-Aldrich®
VE:
1 * 10 g
Lieferant:
Thermo Scientific
Beschreibung:
Desoxycholsäure 98.5%
Artikel-Nr:
(SIAL678163-1G)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
678163-1G
Lokale Artikelnummer::
SIAL678163-1G
Beschreibung:
1,2-Dimethoxy-1,1,2,2-tetramethyldisilan, Sigma-Aldrich®
VE:
1 * 1 g
Artikel-Nr:
(EHERC14710000)
Lieferant:
EHRENSTORFER
Hersteller-Artikelnummer::
C14710000
Lokale Artikelnummer::
EHERC14710000
Beschreibung:
Malathion (1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyldithiophosphat)
VE:
1 * 0,1 g
Artikel-Nr:
(7613.1000)
Lieferant:
Avantor
Lokale Artikelnummer::
BAKR7613.1000
Beschreibung:
EDTA Dinatriumsalz 0.01 mol/l (0.02 N) in wässriger Lösung, BAKER ANALYZED®, Laborreagens, J.T.Baker®
VE:
1 * 1 L
Artikel-Nr:
(PROOLGC1205)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
LGC1205
Lokale Artikelnummer::
PROOLGC1205
Beschreibung:
Malathion (1,2-Bis(ethoxycarbonyl)ethyl-O,O-dimethyldithiophosphat)
VE:
1 * 250 mg
Lieferant:
Biotium
Beschreibung:
This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.
Lieferant:
Biotium
Beschreibung:
This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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