Sie suchten nach: ligase

Artikel-Nr: (BOSSBS-9121R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9121R-A647

Lokale Artikelnummer:: BOSSBS-9121R-A647

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9120R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9120R-FITC

Lokale Artikelnummer:: BOSSBS-9120R-FITC

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-3634R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-3634R-FITC

Lokale Artikelnummer:: BOSSBS-3634R-FITC

Beschreibung: Siah2 is a E3 Ubiquitin ligase protein that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targets. Siah2 triggers the ubiquitin-mediated degradation of many proteins, including transcription regulators (e.g. POU2AF1, PML, NCOR1), cell surface receptors (e.g. DCC), antiapoptotic proteins (e.g. BAG1), and proteins involved in synaptic vesicle function in neurons (e.g. SYP). Siah2 has some overlapping function with SIAH1 but is able to trigger the ubiquitin-mediated degradation of TRAF2, whereas SIAH1 can not.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9121R-A680)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9121R-A680

Lokale Artikelnummer:: BOSSBS-9121R-A680

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9121R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9121R-A750

Lokale Artikelnummer:: BOSSBS-9121R-A750

Beschreibung: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Has some glucocorticoid receptor-responsive activity.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8383R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8383R-A647

Lokale Artikelnummer:: BOSSBS-8383R-A647

Beschreibung: Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (UBE1s), ubiquitin-conjugating enzymes (UBE2s), and ubiquitin-protein ligases (UBE3s). When ubiquitin is activated by a UBE1, it is transferred to the cysteine residue on a UBE2. UBE2 then binds a UBE3, which transfers the ubiquitin from the UBE2 cysteine to a lysine residue on the target protein. Ubiquitin-conjugating enzyme E2 Q1 (UBE2Q1), also known as ubiquitin-protein ligase Q1 or ubiquitin carrier protein Q1, is an 422 amino acid protein belonging to the ubiquitin-conjugating enzyme (UBE2) family. Two named isoforms of UBE2Q1 exist as a result of alternative splicing events.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8383R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8383R-HRP

Lokale Artikelnummer:: BOSSBS-8383R-HRP

Beschreibung: Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (UBE1s), ubiquitin-conjugating enzymes (UBE2s), and ubiquitin-protein ligases (UBE3s). When ubiquitin is activated by a UBE1, it is transferred to the cysteine residue on a UBE2. UBE2 then binds a UBE3, which transfers the ubiquitin from the UBE2 cysteine to a lysine residue on the target protein. Ubiquitin-conjugating enzyme E2 Q1 (UBE2Q1), also known as ubiquitin-protein ligase Q1 or ubiquitin carrier protein Q1, is an 422 amino acid protein belonging to the ubiquitin-conjugating enzyme (UBE2) family. Two named isoforms of UBE2Q1 exist as a result of alternative splicing events.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8391R-FITC)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8391R-FITC

Lokale Artikelnummer:: BOSSBS-8391R-FITC

Beschreibung: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-8391R-A555)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-8391R-A555

Lokale Artikelnummer:: BOSSBS-8391R-A555

Beschreibung: E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6872R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6872R-CY7

Lokale Artikelnummer:: BOSSBS-6872R-CY7

Beschreibung: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6872R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6872R-A647

Lokale Artikelnummer:: BOSSBS-6872R-A647

Beschreibung: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6389R-A488)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6389R-A488

Lokale Artikelnummer:: BOSSBS-6389R-A488

Beschreibung: E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of PCNP. May participate in methylation-dependent transcriptional regulation. Important for G1/S transition. Overexpression causes G1 phase cell arrest.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6916R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6916R-CY5

Lokale Artikelnummer:: BOSSBS-6916R-CY5

Beschreibung: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-6916R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-6916R-A750

Lokale Artikelnummer:: BOSSBS-6916R-A750

Beschreibung: Rab effector protein acting as linker between gamma-adaptin, RAB4A or RAB5A. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Stimulates nucleotide exchange on RAB5A. Can act as a ubiquitin ligase.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-11383R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-11383R-A647

Lokale Artikelnummer:: BOSSBS-11383R-A647

Beschreibung: ACSF1 is a 672 amino acid protein belonging to the ATP-dependent AMP-binding enzyme family. Encoded by a gene that maps to human chromosome 12q24.31, ACSF1 is highly expressed in kidney, heart and brain, and shows similar neural expression as HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). Existing as three alternatively spliced isoforms, ACSF1 participates in ATP binding, ligase activity, acetoacetate-CoA ligase activity and nucleotide binding. The ACSF1 promoter is a known PPAR?target gene, with the nuclear receptor recruited to the ACSF1 promoter by direct interaction with stimulating protein-1 (Sp1). ACSF1 activates acetoacetate and is highly regulated by modulators that affect HMGCR and cholesterol biosynthesis.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9225R-A488)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9225R-A488

Lokale Artikelnummer:: BOSSBS-9225R-A488

Beschreibung: Might act as an E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes and then transfers it to substrates, which could be nuclear proteins. Could play a role as a coactivator for androgen- and, to a lesser extent, progesterone-dependent transcription.

VE: 1 * 100 µl

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