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BIOSS INC
Artikel-Nr:
(BOSSBS-6070R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6070R-A647
Lokale Artikelnummer::
BOSSBS-6070R-A647
Beschreibung:
LLGL1 is a protein that is similar to a tumor suppressor in Drosophila. The protein is part of a cytoskeletal network and is associated with nonmuscle myosin II heavy chain and a kinase that specifically phosphorylates this protein at serine residues. The gene for LLGL1 is located within the Smith-Magenis syndrome region on chromosome 17. LLGL2 is a protein similar to lethal giant larvae of Drosophila. In fly, the protein's ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10151R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10151R-HRP
Lokale Artikelnummer::
BOSSBS-10151R-HRP
Beschreibung:
Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and influenza A use it to export their unspliced or incompletely spliced RNAs out of the nucleus. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0036R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0036R-A647
Lokale Artikelnummer::
BOSSBS-0036R-A647
Beschreibung:
Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9575R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9575R
Lokale Artikelnummer::
BOSSBS-9575R
Beschreibung:
Anti-RPE65 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6060R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6060R-FITC
Lokale Artikelnummer::
BOSSBS-6060R-FITC
Beschreibung:
Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments (PubMed:18039658). Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to the cell surface or direct it to lysosomes for degradation. Can induce ubiquitination of LDLR leading to its subsequent degradation (PubMed:18799458, PubMed:17461796, PubMed:18197702, PubMed:22074827). Inhibits intracellular degradation of APOB via the autophagosome/lysosome pathway in a LDLR-independent manner. Involved in the disposal of non-acetylated intermediates of BACE1 in the early secretory pathway (PubMed:18660751). Inhibits epithelial Na(+) channel (ENaC)-mediated Na(+) absorption by reducing ENaC surface expression primarily by increasing its proteasomal degradation. Regulates neuronal apoptosis via modulation of LRP8/APOER2 levels and related anti-apoptotic signaling pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1728R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1728R-CY5
Lokale Artikelnummer::
BOSSBS-1728R-CY5
Beschreibung:
Receptor for the CX3C chemokine fractalkine and mediates both its adhesive and migratory functions. Acts as coreceptor with CD4 for HIV-1 virus envelope protein (in vitro). Isoform 2 and isoform 3 seem to be more potent HIV-1 coreceptors than isoform 1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1788R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1788R-A647
Lokale Artikelnummer::
BOSSBS-1788R-A647
Beschreibung:
Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13487R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13487R-CY5
Lokale Artikelnummer::
BOSSBS-13487R-CY5
Beschreibung:
Golgin 245 is also known as p230, GCP2, GOLG or golgi autoantigen and is a 2,230 amino acid protein that is expressed as three isoforms. Golgin 245 is localized to the cytoplasm in cells and is a member of the golgin family, all of which are peripheral membrane proteins associated with the Golgi complex. Golgin 245 has a carboxyl-terminal GRIP domain, which attaches to the trans-Golgi network (TGN) and TGN-derived vesicles. It is thought that the interaction that takes place between golgin 245 and MACF1, which cross-links microtubules to the Actin cytoskeleton, allows proteins to be transported from the TGN to the cell periphery. against golgin 245 are associated with two chronic disorders known as Sjé°ƒren's syndrome and Hepatitis B.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13536R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13536R-HRP
Lokale Artikelnummer::
BOSSBS-13536R-HRP
Beschreibung:
G protein-coupled receptor that is activated by a major product of dietary fiber digestion, the short chain fatty acids (SCFAs), and that plays a role in the regulation of whole-body energy homeostasis and in intestinal immunity. In omnivorous mammals, the short chain fatty acids acetate, propionate and butyrate are produced primarily by the gut microbiome that metabolizes dietary fibers. SCFAs serve as a source of energy but also act as signaling molecules. That G protein-coupled receptor is probably coupled to the pertussis toxin-sensitive, G(i/o)-alpha family of G proteins but also to the Gq family (PubMed:12496283, PubMed:12711604, PubMed:23589301). Its activation results in the formation of inositol 1,4,5-trisphosphate, the mobilization of intracellular calcium, the phosphorylation of the MAPK3/ERK1 and MAPK1/ERK2 kinases and the inhibition of intracellular cAMP accumulation. May play a role in glucose homeostasis by regulating the secretion of GLP-1, in response to short-chain fatty acids accumulating in the intestine. May also regulate the production of LEP/Leptin, a hormone acting on the central nervous system to inhibit food intake. Finally, may also regulate whole-body energy homeostasis through adipogenesis regulating both differentiation and lipid storage of adipocytes. In parallel to its role in energy homeostasis, may also mediate the activation of the inflammatory and immune responses by SCFA in the intestine, regulating the rapid production of chemokines and cytokines. May also play a role in the resolution of the inflammatory response and control chemotaxis in neutrophils. In addition to SCFAs, may also be activated by the extracellular lectin FCN1 in a process leading to activation of monocytes and inducing the secretion of interleukin-8/IL-8 in response to the presence of microbes (PubMed:21037097).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12153R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12153R-HRP
Lokale Artikelnummer::
BOSSBS-12153R-HRP
Beschreibung:
Beta-taxilin promotes nerve regeneration and may be involved in intracellular vesicle transport. Expressed predominantly in cardiac and skeletal muscle, beta-taxilin binds to the coiled coil region of the syntaxin family members STX1A, STX3A, and STX4A. Beta- and gamma-taxilins, bind to the alpha subunit of the nascent polypeptide-associated complex (NAC) and affect its nuclear distribution, suggesting that the taxilin family is involved not only in the translational process through its interaction with NAC but also in the transcriptional process through its interaction with alphaNAC alone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1294R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1294R-FITC
Lokale Artikelnummer::
BOSSBS-1294R-FITC
Beschreibung:
Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4877R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4877R-A488
Lokale Artikelnummer::
BOSSBS-4877R-A488
Beschreibung:
The complement factor C3 consists of an alpha and a beta chain. C3 is a central factor in the complement cascade. It is central to the alternative pathway that leads to the C3 convertase C3bBb. The classical mannose binding lectin activation pathway leads to the C3 convertase C4b2a. These convertases cleave C3 resulting in C3a and C3b. Further degradation leads to the formation of the alpha chain products C3d, C3g and C3c. C3 is an acute phase protein that is produced by a wide range of tissues, including renal epithelial cells and hepatocytes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2692R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2692R-CY3
Lokale Artikelnummer::
BOSSBS-2692R-CY3
Beschreibung:
Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0760R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0760R-FITC
Lokale Artikelnummer::
BOSSBS-0760R-FITC
Beschreibung:
Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Is involved in adipocyte differentiation. Isoform 1 is recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15583R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15583R-CY5
Lokale Artikelnummer::
BOSSBS-15583R-CY5
Beschreibung:
This gene encodes a type I transmembrane protein and is a tumor-specific endothelial marker that has been implicated in colorectal cancer. The encoded protein has been shown to also be a docking protein or receptor for Bacillus anthracis toxin, the causative agent of the disease, anthrax. The binding of the protective antigen (PA) component, of the tripartite anthrax toxin, to this receptor protein mediates delivery of toxin components to the cytosol of cells. Once inside the cell, the other two components of anthrax toxin, edema factor (EF) and lethal factor (LF) disrupt normal cellular processes. Three alternatively spliced variants that encode different protein isoforms have been described.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5104R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5104R-HRP
Lokale Artikelnummer::
BOSSBS-5104R-HRP
Beschreibung:
Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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