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BIOSS INC
Artikel-Nr:
(BOSSBS-5838R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5838R-A350
Lokale Artikelnummer::
BOSSBS-5838R-A350
Beschreibung:
Can mediate aggregation most likely through a homophilic molecular interaction.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12140R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12140R-A350
Lokale Artikelnummer::
BOSSBS-12140R-A350
Beschreibung:
A guanylate kinase is a phosphotransferase that produces ADP and GDP from the substrates ATP and GMP. SAPAP4 is a 992 amino acid protein that likely localizes to the postsynaptic membrane of neurons to enhance neuronal signaling. SAPAP4 could act as a signaling molecule which interacts with the human genes DLG1 and DLG4/PSD-95. The gene encoding SAPAP4, DLGAP4, maps to human chromosome 20. Comprising approximately 2% of the human genome, chromosome 20 contains nearly 63 million bases that encode over 600 genes, some of which are associated with Creutzfeldt-Jakob disease, amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome. Additionally, chromosome 20 contains a region with numerous genes which are thought important for seminal production and may be potential targets for male contraception.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7463R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7463R-A488
Lokale Artikelnummer::
BOSSBS-7463R-A488
Beschreibung:
B-ATF is a nuclear basic leucine zipper protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of B-ATF mediates dimerization with members of the Jun family of proteins. The B-ATF protein does not homodimerize efficiently, but rather forms a heterodimer preferentially with c-Jun. The B-ATF/c-Jun protein complex can interact with DNA containing a consensus binding site for AP-1, suggesting that B-ATF functions as a tissue-specific modulator of the AP-1 transcription complex in human cells. B-ATF also associates with IFP35, a leucine zipper protein that translocates to the nucleus following IFN treatment. The gene encoding B-ATF, also designated SFA-2, is strongly expressed in mature T and B lymphocytes, and is up-regulated after transformation by human T-cell leukemia virus type I.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1391R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1391R-CY3
Lokale Artikelnummer::
BOSSBS-1391R-CY3
Beschreibung:
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest, activation of DNA repair and apoptosis in response to the presence of DNA double-strand breaks. May also negatively regulate cell cycle progression during unperturbed cell cycles. Following activation, phosphorylates numerous effectors preferentially at the consensus sequence [L-X-R-X-X-S/T]. Regulates cell cycle checkpoint arrest through phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their activity. Inhibition of CDC25 phosphatase activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. May also phosphorylate NEK6 which is involved in G2/M cell cycle arrest. Regulates DNA repair through phosphorylation of BRCA2, enhancing the association of RAD51 with chromatin which promotes DNA repair by homologous recombination. Also stimulates the transcription of genes involved in DNA repair (including BRCA2) through the phosphorylation and activation of the transcription factor FOXM1. Regulates apoptosis through the phosphorylation of p53/TP53, MDM4 and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may alleviate inhibition by MDM2, leading to accumulation of active p53/TP53. Phosphorylation of MDM4 may also reduce degradation of p53/TP53. Also controls the transcription of pro-apoptotic genes through phosphorylation of the transcription factor E2F1. Tumor suppressor, it may also have a DNA damage-independent function in mitotic spindle assembly by phosphorylating BRCA1. Its absence may be a cause of the chromosomal instability observed in some cancer cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12279R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12279R-HRP
Lokale Artikelnummer::
BOSSBS-12279R-HRP
Beschreibung:
Probable transcription factor, which may be involved in spermatogenesis and oogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12175R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12175R-A680
Lokale Artikelnummer::
BOSSBS-12175R-A680
Beschreibung:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily G. This member is a gamma subunit functioning as a modulatory molecule. Alternative splicing results in two transcript variants encoding distinct isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4692R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4692R-A680
Lokale Artikelnummer::
BOSSBS-4692R-A680
Beschreibung:
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth. Through phosphorylation of the anti-apoptotic protein MCL1, may control cell apoptosis in response to growth factors deprivation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1990R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1990R-CY7
Lokale Artikelnummer::
BOSSBS-1990R-CY7
Beschreibung:
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3136R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3136R-A555
Lokale Artikelnummer::
BOSSBS-3136R-A555
Beschreibung:
Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through the cellular surface tyrosine kinase receptors. There are four members of the FGF receptor family: FGFR-1 (flg), FGFR-2 (bek, KGFR), FGFR-3 and FGFR-4. Each receptor contains an extracellular ligand binding domain, a transmembrane region and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR-1 can be phosphorylated: Tyr463, Tyr583, Tyr585, Tyr653, Tyr654, Tyr730 and Tyr766. Tyrosine 653 and 654 are important for catalytic activity of the activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCgamma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13610R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13610R-A680
Lokale Artikelnummer::
BOSSBS-13610R-A680
Beschreibung:
May operate as a co-chaperone of the male germ cell- and haploid stage-specific Hsp70 proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15449R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15449R-CY3
Lokale Artikelnummer::
BOSSBS-15449R-CY3
Beschreibung:
HEG1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12284R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12284R-A647
Lokale Artikelnummer::
BOSSBS-12284R-A647
Beschreibung:
Cholinephosphotransferase catalyses the final step in the synthesis of phosphatidylcholine by the transfer of phosphocholine from CDP-choline to diacylglycerol. The synthesis of phosphatidylethanolamine by ethanolaminephosphotransferase occurs using an analogous reaction. This gene codes for a choline/ethanolaminephosphotransferase. The protein can synthesize either choline- or ethanolamine- containing phospholipids. Two alternatively spliced transcripts encoding the same isoform have been identified. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2748R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2748R-A350
Lokale Artikelnummer::
BOSSBS-2748R-A350
Beschreibung:
Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2409R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2409R-A750
Lokale Artikelnummer::
BOSSBS-2409R-A750
Beschreibung:
Amphiphysin is associated with the cytoplasmic surface of synaptic vesicles. A subset of patients with stiff man syndrome who were also affected by breast cancer are positive for auto against this protein. Alternate splicing of this gene results in two transcript variants (Amphiphysin 1 and Amphiphysin 2) encoding different isoforms. Additional splice variants have been described, but their full length sequences have not been determined.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2539R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2539R
Lokale Artikelnummer::
BOSSBS-2539R
Beschreibung:
Anti-TRIM63 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5966R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5966R-A555
Lokale Artikelnummer::
BOSSBS-5966R-A555
Beschreibung:
The LIM-only (LMO) proteins, LMO1 and LMO2, are nuclear factors that are characterized by a conserved LIM domain (1). The LIM domain consists of a cysteine-rich zinc-binding motif that is present in a variety of transcription factors, including the LIM homeobox (LHX) proteins expressed in the central nervous system and involved in cell differentiation (2). LMO1 and LMO2 are expressed in the adult CNS in a cell type-specific manner, where they are differentially regulated by neuronal activity and are involved in regulating the cellular differentiated phenotype of neurons (3). LMO2 lacks a specific DNA-binding homeobox domain but rather assembles into transcriptional regulatory complexes to mediate gene expression by interacting with the widely expressed nuclear LIM interactor (NLI) (4). NLI, known also as CLIM-1, and the related protein CLIM-2 facilitate the formation of heteromeric LIM complexes and also enhance the nuclear retention of LIM proteins (5). LMO2 and the related protein LMO4 are expressed in thymic precursor cells (6). LMO4 is also expressed in mature T cells, cranial neural crest cells, somite, dorsal limb bud mesenchyme, motor neurons, and Schwann cell progenitors (7).
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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