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BIOSS INC
Artikel-Nr:
(BOSSBS-11208R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11208R-A750
Lokale Artikelnummer::
BOSSBS-11208R-A750
Beschreibung:
Sox genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at least 40 different loci that rapidly diverged in various animal lineages. At present, 30 Sox genes have been identified. Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8050R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8050R-FITC
Lokale Artikelnummer::
BOSSBS-8050R-FITC
Beschreibung:
Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5506R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5506R-CY7
Lokale Artikelnummer::
BOSSBS-5506R-CY7
Beschreibung:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK11 is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5522R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5522R-A555
Lokale Artikelnummer::
BOSSBS-5522R-A555
Beschreibung:
Nudel is important for normal cortical development. It is invovled in microtubule organization, nuclear translocation, and neuronal positioning in concert with various other factors (including Lis1, Pafah1b1, Pahfah1b2, dynein, dynorphin A and cdk5). Western blot analysis of mouse tissues shows abundant expression of Nudel in brain and testis, and much lower expression in heart, liver, kidney, and skeletal muscle. In fractionated rat brain, Nudel and Lis1 are both found in fractions enriched for postsynaptic density proteins. Immunostaining of embryonic day 18 mouse brain sections revealed staining of migrating neurons and thalamocortical axons of the intermediate zone of the developing cerebral cortex, as well as several other developing brain regions. The deduced protein contains 345 amino acids and has a calculated molecular mass of 38.4 kDa. It has a coiled coil motif (residues 19 to 201), followed by several potential phosphorylation sites for casein kinase II, protein kinase C or CDK5. Nudel shares about 50% identity with mouse and human NUDE proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5584R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5584R
Lokale Artikelnummer::
BOSSBS-5584R
Beschreibung:
This is a calcium-independent, phospholipid-dependent, serine- and threonine-specific enzyme. Essential for T-cell receptor (TCR)-mediated T-cell activation, but is dispensable during TCR-dependent thymocyte development. Links the TCR signaling complex to the activation of NF-kappa-B in mature T lymphocytes. Required for interleukin-2 (IL2) production. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11624R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11624R-A350
Lokale Artikelnummer::
BOSSBS-11624R-A350
Beschreibung:
Olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that leads to the perception of smell. While they share a seven transmembrane domain structure with many neurotransmitter and hormone receptors, olfactory receptors are responsible for the recognition and transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. Both OR2A4 (olfactory receptor 2A4) and OR2A7 (olfactory receptor 2A7) are 310 amino acid multi-pass membrane proteins that belong to the G-protein coupled receptor 1 family. The gene that encodes OR2A4 maps to human chromosome 6q23, while the gene that encodes OR2A7 maps to human chromosome 7q35.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1373R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1373R-A488
Lokale Artikelnummer::
BOSSBS-1373R-A488
Beschreibung:
Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12435R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12435R-A680
Lokale Artikelnummer::
BOSSBS-12435R-A680
Beschreibung:
FRAT1 and FRAT2 were originally characterised as proteins frequently rearranged in advanced T cell lymphoma, and they have since been identified as proto-oncogenes involved in tumourigenesis. These proteins share significant homology with the Xenopus glycogen synthase kinase-3 (xGSK-3) binding protein, which is designated GBP and is essential for the formation of the dorsal-ventral axis during embryonic development. Establishment of these embryonic axes is mediated by the Wnt intracellular Signalling pathway. Wnt Signalling is regulated in part by the activity of GSK-3, which phosphorylates and thereby facilitates the degradation of catenin. GBP binds to GSK-3 and inhibits this phosphorylation, resulting in the accumulation of catenin and the subsequent transcription of Wnt target genes. Like GBP, FRAT2 has been shown to bind xGSK-3, suggesting that FRAT1 and FRAT2 may be GSK-3 regulatory proteins.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1529R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1529R-CY7
Lokale Artikelnummer::
BOSSBS-1529R-CY7
Beschreibung:
Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilisation. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7917R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7917R-CY5
Lokale Artikelnummer::
BOSSBS-7917R-CY5
Beschreibung:
NUCKS1
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8005R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8005R-A350
Lokale Artikelnummer::
BOSSBS-8005R-A350
Beschreibung:
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specicic manner; the function probbaly involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7785R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7785R-A350
Lokale Artikelnummer::
BOSSBS-7785R-A350
Beschreibung:
Required for initiation of chromosomal DNA replication.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6767R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6767R-CY7
Lokale Artikelnummer::
BOSSBS-6767R-CY7
Beschreibung:
Class E VPS protein involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome. Binds to the phospholipid lysobisphosphatidic acid (LBPA) which is abundant in MVBs internal membranes. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Appears to be an adapter for a subset of ESCRT-III proteins, such as CHMP4, to function at distinct membranes. Required for completion of cytokinesis. Involved in HIV-1 virus budding. Can replace TSG101 it its role of supporting HIV-1 release; this function implies the interaction with CHMP4B. May play a role in the regulation of both apoptosis and cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12543R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12543R-FITC
Lokale Artikelnummer::
BOSSBS-12543R-FITC
Beschreibung:
ATF-6 is a member of the basic-leucine zipper family of transcription factors. Endoplasmic reticulum stress causes cleavage of transmembrane ATF-6 and transclocation of active ATF-6 to the nucleus. Soluble ATF-6 can exist as either an ATF-6beta homodimer or an ATF-6Alpha/beta heterodimer. Binding of the ATF-6beta homodimer or ATF-6Alpha/beta heterodimer to the nuclear transcription factor Y C (NF-YC) induces ER chaperone transcription.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5130R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5130R-A488
Lokale Artikelnummer::
BOSSBS-5130R-A488
Beschreibung:
Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylates DCLRE1C, c-Abl/ABL1, histone H1, HSPCA, c-jun/JUN, p53/TP53, PARP1, POU2F1, DHX9, SRF, XRCC1, XRCC1, XRCC4, XRCC5, XRCC6, WRN, MYC and RFA2. Can phosphorylate C1D not only in the presence of linear DNA but also in the presence of supercoiled DNA. Ability to phosphorylate p53/TP53 in the presence of supercoiled DNA is dependent on C1D. Contributes to the determination of the circadian period length by antagonizing phosphorylation of CRY1 'Ser-588' and increasing CRY1 protein stability, most likely through an indirect machanism. Interacts with CRY1 and CRY2; negatively regulates CRY1 phosphorylation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5751R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5751R-FITC
Lokale Artikelnummer::
BOSSBS-5751R-FITC
Beschreibung:
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. MATK is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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