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BIOSS INC
Artikel-Nr:
(BOSSBS-0334R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0334R-A350
Lokale Artikelnummer::
BOSSBS-0334R-A350
Beschreibung:
May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12540R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12540R
Lokale Artikelnummer::
BOSSBS-12540R
Beschreibung:
ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9068R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9068R-FITC
Lokale Artikelnummer::
BOSSBS-9068R-FITC
Beschreibung:
PBGD, also designated hydroxymethylbilane synthase, is a cytoplasmic enzyme found in the heme synthesis pathway. PBGD belongs to the HMBS (hydroxymethylbilane synthase) family. Deficiency of PBGD causes errors in pyrrole metabolism, which in turn leads to an inherited autosomal disorder called acute intermittent porphyria (AIP). AIP is characterized by acute attacks of neurological dysfunctions with hypertension, tachycardia, peripheral neurologic disturbances, abdominal pain and excessive amounts of aminolevulinic acid and porphobilinogen in the urine.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8468R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8468R-FITC
Lokale Artikelnummer::
BOSSBS-8468R-FITC
Beschreibung:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11279R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11279R-CY3
Lokale Artikelnummer::
BOSSBS-11279R-CY3
Beschreibung:
ESE-1, a member of the Ets family of transcription factors, critically regulates epithelial cell differentiation and mediates vascular inflammation. ESE-1 is strongly expressed in vascular endothelium and smooth muscle cells where it is induced in response to inflammatory cytokines and lipopolysaccharides, interacts with NF-KappaB to induce nitric oxide synthase, and is induced during terminal differentiation of epidermal and primary keratinocytes. In addition, ESE-1 is upregulated upon differentiation of corneal epithelium and interacts with Sp1 and AP-1 proteins to induce squamous differentiation marker expression in bronchial epithelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12431R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12431R-A488
Lokale Artikelnummer::
BOSSBS-12431R-A488
Beschreibung:
Involved in cytoskeletal rearrangements required for lymphocyte migration in response of chemokines. Activates RAC1 and RAC2, but not CDC42, by functioning as a guanine nucleotide exchange factor (GEF), which exchanges bound GDP for free GTP. May also participate in IL2 transcriptional activation via the activation of RAC2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3272R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3272R-CY7
Lokale Artikelnummer::
BOSSBS-3272R-CY7
Beschreibung:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13165R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13165R
Lokale Artikelnummer::
BOSSBS-13165R
Beschreibung:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12976R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12976R-CY7
Lokale Artikelnummer::
BOSSBS-12976R-CY7
Beschreibung:
Acid ceramidase catalyzes the degradation of ceramide in normal tissues, and deficiency leads to accumulation of ceramide in tissues, a hallmark of Farber disease. Effected individuals experience early onset joint problems and neurological problems, owing to mutations in the acid ceramidase gene. Bioinformatic analysis of gene expression also reveals acid ceramidase to be among the 5 most important genes associated with melanoma. In addition to ceramide hydrolysis, purified acid ceramidase also exhibits the ability to catalyze ceramide synthesis, utilizing [14C]lauric acid and sphingosine as substrates. Interestingly, pH regulates which reaction is favored; for hydrolysis the pH optimum is 4.5, whereas for the reverse reaction favors a pH of 5.5, further supporting a complex and central role for acid ceramidase in sphingolipid metabolism.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13114R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13114R-CY3
Lokale Artikelnummer::
BOSSBS-13114R-CY3
Beschreibung:
ETV3L is a transcriptional regulator, which belongs to the ETS family and contains 1 ETS DNA-binding domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13653R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13653R-FITC
Lokale Artikelnummer::
BOSSBS-13653R-FITC
Beschreibung:
Leupaxin is a 386 amino acid cytoplasmic protein and member of the paxillin family. Leupaxin is highly expressed in lymphoid tissues such as spleen, lymph node, thymus and appendix, with low expression in bone marrow and fetal liver. Consisting of four leucine-rich LD-motifs at the N-terminus and four LIM domains at the C-terminus, leupaxin associates with a member of the focal adhesion kinase family, PYK2, in lymphoid cells. The leupaxin and PYK2 complex is involved in cell type-specific signaling in which it regulates signaling at sites of adhesion. Leupaxin is a substrate for tyrosine kinase in lymphoid cells and is suggested to participate in and be regulated by tyrosine kinase activity. Leupaxin may be a potential progression marker for a subset of prostate cancer and may act as a novel coactivator of the androgen receptor.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1175R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1175R
Lokale Artikelnummer::
BOSSBS-1175R
Beschreibung:
Anti-SHBG Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1108R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1108R-A555
Lokale Artikelnummer::
BOSSBS-1108R-A555
Beschreibung:
Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2381R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2381R-A680
Lokale Artikelnummer::
BOSSBS-2381R-A680
Beschreibung:
Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP68 binds the 7S RNA, SRP72 binds to this complex subsequently. This ribonucleoprotein complex might interact directly with the docking protein in the ER membrane and possibly participate in the elongation arrest function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12493R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12493R-A750
Lokale Artikelnummer::
BOSSBS-12493R-A750
Beschreibung:
APOBEC2 is a 224 amino acid protein that belongs to the cytidine and deoxycytidylate deaminase family. Expressed exclusively in heart and skeletal muscle, APOBEC2 is thought to be a probable C (cytidine) to U (uridine) editing enzyme. However, unlike other members of the family, such as APOBEC1, which mediates the editing of apolipoprotein (apo) B mRNA, APOBEC2 does not display any detectable apoB mRNA editing activity. Also, APOBEC2 has been shown to have low, but definite, intrinsic cytidine deaminase activity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0559R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0559R-CY3
Lokale Artikelnummer::
BOSSBS-0559R-CY3
Beschreibung:
CDK5 is serine/threonine kinase involved in synaptic regulation and neuronal development; phosphorylates synaptic protein Pctaire1; regulates acetylcholine receptor expression.CDK5 is a member of the cyclindependent kinase family of serine/threonine kinases. It is present in numerous mammalian tissues including kidney, testes, and ovary. Its activity is detected almost exclusively in brain extracts. Neuronal and muscle cells contain the highest amount of this protein. Similar to other Cdks, monomeric Cdk5 displays no enzymatic activity, but Cdk5 is not activated by cyclins. Instead, the p35 protein, which is expressed solely in the brain, activates Cdk5. Cdk5 interacts with D1 and D3 type G1 cyclins and can phosphorylate histone H1, TAU, MAP2 and NF-H and NF-M. Cdk5 activity is involved in terminal differentiation of neurons and muscle cells.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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