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4-(4-Methylpiperazin-1-yl)benzoic+acid
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4-(4-Methylpiperazin-1-yl)benzoic+acid
Artikel-Nr:
(BOSSBS-13290R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13290R-CY3
Lokale Artikelnummer::
BOSSBS-13290R-CY3
Beschreibung:
Gene amplification is associated with tumor stage and progression in human gliomas. Several amplified loci are identified and comprise multiple genes. The glioma amplified sequence 41 (GAS41) is an evolutionarily conserved eukaryotic protein found in diverse species. GAS41 is related to the AF-9 and ENL proteins, which are putative transcription factors in some acute leukemias, and interacts with a component of the nuclear matrix, NuMA, in interphase cells. GAS41 has a dotted staining pattern in interphase nuclei and a uniform distribution in mitotic cells. GAS41 is ubiquitously expressed, with the highest levels of expression in human brain. In neuroblastoma, GAS41 is located in the nucleoli, but not in the nucleoplasm. GAS41 also binds to the MLL fusion partner AF10, which is involved in two distinct chromosomal translocations associated with hematologic malignancy. In addition, GAS41 interacts with INI1 (Integrase Interactor), which is a human homologue of the yeast SNF5 protein, a component of the SWI/SNF complex. The GAS41 gene maps to human chromosome 12q13-q15.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13230R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13230R-CY7
Lokale Artikelnummer::
BOSSBS-13230R-CY7
Beschreibung:
Glycosyltransferases that mediate the regio- and stereoselective transfer of sugars, such as the fucosyltransferases, determine cell surface-carbohydrate profiles, which is an essential interface for biological recognition processes. Fucosyltransferases catalyze the covalent association of fucose to different positional linkages in sugar acceptor molecules. The carbohydrate moieties generated and covalently attached to cell surfaces are necessary to ensure a surface contour that satisfies physiological roles, which are reliant on adhesion molecules such as Selectins (1-3). Hematopoietic lineages rely on Fucosyltransferases to confer a surface carbohydrate phenotype, which mediates proper cell adhesion molecule recruitment and cell trafficking (4-6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13201R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13201R-CY5
Lokale Artikelnummer::
BOSSBS-13201R-CY5
Beschreibung:
The FOX family of transcription factors share a common DIUA binding domain termed a winged-helix or forkhead domain. Many FOX proteins play important roles in development, metabolism, cancer and aging. Development of the vertebrate gut is controlled by paracrine crosstalk between the endodermal epithelium and the associated splanchnic mesoderm. FOXF2 (forkhead box F2), also known as FKHL or FREAC2, is expressed in lung and placenta, and has been shown to transcriptionally activate several lung-specific genes. FOXF2 interacts with transcription factors TFIIB and TBP, and may be involved in regulating transcription in embryogenesis and pattern formation in multicellular organisms. FOXF2-deficient mice develop cleft palate and an abnormal tongue, which suggests that FOXF2 may be critical for palatogenesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12219R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12219R-FITC
Lokale Artikelnummer::
BOSSBS-12219R-FITC
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF426 (Zinc finger protein 426), also known as MGC2663, is a 554 amino acid protein that is thought to be involved in transcriptional regulation. Localized to the nucleus, ZNF426 contains one KRAB domain and 12 C2H2-type zinc fingers through which it may convey DNA, RNA and protein binding capabilities. Specifically, ZNF426 may interact with the viral protein KSHV ORF 50 and, through this interaction, may activate viral gene transcription.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9244R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9244R-A350
Lokale Artikelnummer::
BOSSBS-9244R-A350
Beschreibung:
Tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein 1 (IFP1), is a 488 amino acid member of the TRIM family, also known as the RING-B-box coiled-coil (RBCC) family. Members of the RBCC family have an N-terminal RING finger, followed by one or two zinc-binding domains (B-box domains), a leucine coiled-coil region and a variable C-terminal domain. Three isoforms of TRIM34 exist as a result of alternative splicing events. Isoform 1, the most abundant isoform, is highly expressed in placenta, spleen, colon and peripheral blood leukocytes. Studies have shown that Interferon (IFN) stimulation leads to an upregulation of TRIM34. These findings suggest that TRIM34 maybe a downstream effector that mediates IFN activities.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1258R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1258R-A350
Lokale Artikelnummer::
BOSSBS-1258R-A350
Beschreibung:
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1253R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1253R-CY7
Lokale Artikelnummer::
BOSSBS-1253R-CY7
Beschreibung:
Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct cells. It may play an important role in gastrointestinal tract water transport and in glycerol metabolism.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9515R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9515R-CY7
Lokale Artikelnummer::
BOSSBS-9515R-CY7
Beschreibung:
Catalyzes the last step in the transsulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure.Defects in CTH are the cause of cystathioninuria (CSTNU). It is an autosomal recessive phenotype characterized by abnormal accumulation of plasma cystathionine, leading to increased urinary excretion.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9244R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9244R-CY3
Lokale Artikelnummer::
BOSSBS-9244R-CY3
Beschreibung:
Tripartite motif-containing protein 34 (TRIM34), also known as RING finger protein 21 (RNF21) or interferon-responsive finger protein 1 (IFP1), is a 488 amino acid member of the TRIM family, also known as the RING-B-box coiled-coil (RBCC) family. Members of the RBCC family have an N-terminal RING finger, followed by one or two zinc-binding domains (B-box domains), a leucine coiled-coil region and a variable C-terminal domain. Three isoforms of TRIM34 exist as a result of alternative splicing events. Isoform 1, the most abundant isoform, is highly expressed in placenta, spleen, colon and peripheral blood leukocytes. Studies have shown that Interferon (IFN) stimulation leads to an upregulation of TRIM34. These findings suggest that TRIM34 maybe a downstream effector that mediates IFN activities.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7758R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7758R-CY3
Lokale Artikelnummer::
BOSSBS-7758R-CY3
Beschreibung:
Tissue specificity: Highly expressed in lung, muscle, testis, brain, heart, liver, leukocyte and spleen. Lower expression in ovary, prostate and kidney.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15521R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15521R-CY5
Lokale Artikelnummer::
BOSSBS-15521R-CY5
Beschreibung:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-19840R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-19840R-A680
Lokale Artikelnummer::
BOSSBS-19840R-A680
Beschreibung:
Interacts with MAD2L2 to form the error prone DNA polymerase seta involved in translesion DNA synthesis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13442R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13442R-A680
Lokale Artikelnummer::
BOSSBS-13442R-A680
Beschreibung:
GSTZ1 is a member of the glutathione S transferase (GSTs) super family, encoding multifunctional enzymes important in the detoxification of electrophilic molecules, including carcinogens, mutagens, and several therapeutic drugs, by conjugation with glutathione. This enzyme also plays a significant role in the catabolism of phenylalanine and tyrosine. Several transcript variants of this gene encode multiple protein isoforms. GSTZ1 shows minimal glutathione-conjugating activity with ethacrynic acid and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole and maleylacetoacetate isomerase activity. It has low glutathione peroxidase activity with T butyl and cumene hydroperoxides and is able to catalyze the glutathione dependent oxygenation of dichloroacetic acid to glyoxylic acid. Highest expression in liver followed by kidney, skeletal muscle and brain. Also expressed in melanocytes, synovium, placenta, breast and fetal liver and heart.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7092R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7092R-A750
Lokale Artikelnummer::
BOSSBS-7092R-A750
Beschreibung:
ZNF420 contains 19 C2H2-type zinc fingers and 1 KRAB domain. It may be involved in transcriptional regulation. It is a negative regulator of p53-mediated apoptosis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8358R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8358R-A680
Lokale Artikelnummer::
BOSSBS-8358R-A680
Beschreibung:
Kelch domain-containing protein 8A (KLHDC8A) is a 350 amino acid protein. KLHDC8A contains seven kelch repeats, each of which is an approximately 50 amino acid long conserved region that forms a tertiary structure beta-propeller. The gene that encodes KLHDC8A is located on chromosome 1, which is the largest human chromosome, spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes Lamin A. The MUTYH gene is located on chromosome 1 and is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7772R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7772R-A680
Lokale Artikelnummer::
BOSSBS-7772R-A680
Beschreibung:
Septin 14, also known as SEPT14, is a 432 amino acid protein that belongs to the septin family. The highly conserved septin family of GTP-binding cytoskeletal proteins is implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis and other cellular functions. Septins polymerise into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. Septin 14 has a GTPase domain followed by a C-terminal coiled-coil domain characteristic of group II septins. Septin 14 interacted with all septins except those that are members of its phylogenetic cluster, including itself. Septin 14 shares highest identity (67%) with Septin 10. Expressed in testis and more weakly in fetal liver, tonsil and thymus, the Septin 14 protein is not detected in testicular cancer or other normal or cancer cell lines. The Septin 14 gene is conserved in chimpanzee, dog, cow, mouse and rat, and maps to human chromosome 7p11.2.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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