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3-Phenylpiperazin-2-one
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3-Phenylpiperazin-2-one
Artikel-Nr:
(BOSSBS-15131R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15131R-A350
Lokale Artikelnummer::
BOSSBS-15131R-A350
Beschreibung:
Chromosome 22 contains over 500 genes and about 49 million bases. Being the second smallest human chromosome, 22 contains a surprising variety of interesting genes. Phelan-McDermid syndrome, Neurofibromatosis type 2 and autism are associated with chromosome 22. A schizophrenia susceptibility locus has been identified on chromosome 22 and studies show that 22q11 deletion symptoms include a high incidence of schizophrenia. Translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein, BCR-Abl, a potent cell proliferation activator found in several types of leukemia. The C22orf13 gene product has been provisionally designated C22orf13 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15115R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15115R-A680
Lokale Artikelnummer::
BOSSBS-15115R-A680
Beschreibung:
Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf72 gene product has been provisionally designated C20orf72 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15177R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15177R-CY5
Lokale Artikelnummer::
BOSSBS-15177R-CY5
Beschreibung:
Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3. The C3orf38 gene product has been provisionally designated C3orf38 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15091R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15091R-A488
Lokale Artikelnummer::
BOSSBS-15091R-A488
Beschreibung:
Representing about 2% of human DNA, chromosome 20 consists of approximately 63 million bases and 600 genes. Chromosome 20 contains a region with numerous genes expressed in the epididymis, which are thought important for seminal production, and some viewed as potential targets for male contraception. The PRNP gene encoding the prion protein associated with spongiform encephalopathies, like Creutzfeldt-Jakob disease, is found on chromosome 20. Amyotrophic lateral sclerosis, spinal muscular atrophy, ring chromosome 20 epilepsy syndrome and Alagille syndrome are also associated with chromosome 20. The C20orf117 gene product has been provisionally designated C20orf117 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15173R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15173R-A555
Lokale Artikelnummer::
BOSSBS-15173R-A555
Beschreibung:
C3orf31 (chromosome 3 open reading frame 31), also known as MGC16471 or DKFZp434E0519, is a 316 amino acid mitochondrial protein that belongs to the MMP37 family and may be involved in translocation of transit peptide-containing proteins across the mitochondrial inner membrane. C3orf24 is encoded by a gene that maps to human chromosome 3p25.2. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11166R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11166R-A750
Lokale Artikelnummer::
BOSSBS-11166R-A750
Beschreibung:
Sortilin-related receptor, also known as Sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL (the main cholesterol-carrying lipoprotein of plasma) and transports it into cells by endocytosis. SorLA is synthesised as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP, receptor-associated protein. SorLa is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous sorLA binds the neuropeptide head activator (HA) and is important for HA Signalling and function. It is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10021R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10021R-A680
Lokale Artikelnummer::
BOSSBS-10021R-A680
Beschreibung:
May function as an inducer of apoptosis. Interacts selectively with ASC and this complex may function as an upstream activator of NF-kappa-B Signalling. Inhibits TNF-alpha induced activation and nuclear translocation of RELA/NF-KB p65. Also inhibits transcriptional activity of RELA. Activates caspase-1 in response to a number of triggers including bacterial or viral infection which leads to processing and release of IL1B and IL18.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9618R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9618R-A555
Lokale Artikelnummer::
BOSSBS-9618R-A555
Beschreibung:
1.C14ORF28, GNB2L1, MLLT3, DRD2 and DARPP-32 are important in the pathogenesis of schizophrenia and bipolar disorder; 2. these two disorders share common disease-related mechanisms linked to dopamine signalling; 3. the expression of these genes is closely correlated; and 4. DRD2 provides the initial trigger in the pathogenesis of these disorders.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8512R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8512R-FITC
Lokale Artikelnummer::
BOSSBS-8512R-FITC
Beschreibung:
Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10118R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10118R-A350
Lokale Artikelnummer::
BOSSBS-10118R-A350
Beschreibung:
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2661R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2661R-CY5
Lokale Artikelnummer::
BOSSBS-2661R-CY5
Beschreibung:
MD1 is a 28 kDa molecule that is associated at the cell surface with RP105 (CD180). RP105 is a leucine-rich repeat (LRR) molecule that is expressed on B lymphocytes. It was first identified by a mAb that protects spleen B cells from irradiation-induced apoptosis. LRR proteins, such as Toll receptors, have a role in innate immunity. MD1 is primarily expressed by B cells, dendritic cells and monocytes, and promotes the recognition of, and subsequent signaling by LPS in the innate immune system. MD1 does not have any homology to other molecules. MD1 when expressed alone behaves as a secretory protein. Expression of MD1 in a cell increases the expression of RP105.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4287R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4287R
Lokale Artikelnummer::
BOSSBS-4287R
Beschreibung:
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8028R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8028R-CY5.5
Lokale Artikelnummer::
BOSSBS-8028R-CY5.5
Beschreibung:
This gene is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3079R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3079R-CY3
Lokale Artikelnummer::
BOSSBS-3079R-CY3
Beschreibung:
Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone and tooth development. Required for normal male and female fertility, and for normal development of milk ducts and acinar structures in the mammary gland during pregnancy. Promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration, and promotes cancer cell invasion. Activates several signaling pathways in response to ligand binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL. Activation of PLCG2 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, that then lead to the activation of protein kinase C family members, especially PRKCD. Phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, leads to activation of the AKT1 signaling pathway. Activated CSF1R also mediates activation of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1. Activated CSF1R transmits signals both via proteins that directly interact with phosphorylated tyrosine residues in its intracellular domain, or via adapter proteins, such as GRB2. Promotes activation of STAT family members STAT3, STAT5A and/or STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3998R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3998R-HRP
Lokale Artikelnummer::
BOSSBS-3998R-HRP
Beschreibung:
Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3806R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3806R-HRP
Lokale Artikelnummer::
BOSSBS-3806R-HRP
Beschreibung:
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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