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BIOSS INC
Artikel-Nr:
(BOSSBS-9649R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9649R-HRP
Lokale Artikelnummer::
BOSSBS-9649R-HRP
Beschreibung:
C17orf82 is a 251 amino acid protein that is encoded by a gene mapping to human chromosome 17. Chromosome 17 makes up over 2.5% of the human genome with about 81 million bases encoding over 1,200 genes. Two key tumor suppressor genes are associated with chromosome 17, namely, p53 and BRCA1. Tumor suppressor p53 is necessary for maintenance of cellular genetic integrity by moderating cell fate through DNA repair versus cell death. Malfunction or loss of p53 expression is associated with malignant cell growth and Li-Fraumeni syndrome. Like p53, BRCA1 is directly involved in DNA repair, specifically it is recognized as a genetic determinant of early onset breast cancer and predisposition to cancers of the ovary, colon, prostate gland and fallopian tubes. Chromosome 17 is also linked to neurofibromatosis, a condition characterized by neural and epidermal lesions, and dysregulated Schwann cell growth. Alexander disease, Birt-Hogg-Dube syndrome and Canavan disease are also associated with chromosome 17.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12990R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12990R-FITC
Lokale Artikelnummer::
BOSSBS-12990R-FITC
Beschreibung:
Binds to and inhibits the transcriptional repressor ZBTB33, which may lead to activation of target genes of the Wnt signaling pathway (By similarity). May associate with and regulate the cell adhesion properties of both C- and E-cadherins. Implicated both in cell transformation by SRC and in ligand-induced receptor signaling through the EGF, PDGF, CSF-1 and ERBB2 receptors. Promotes GLIS2 C-terminal cleavage.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11977R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11977R-CY3
Lokale Artikelnummer::
BOSSBS-11977R-CY3
Beschreibung:
NCS-1 (for neuronal calcium sensor-1, also designated frequenin) belongs to a highly conserved family of EF-hand-containing Ca++-binding proteins expressed mainly in neurons. NCS-1 is localized to neuronal cell bodies and axons throughout the brain and spinal cord. It is also expressed in glial cells and in neuroendocrine bovine adrenal chromaffin and PC12 cells. NCS-1 is a regulatory protein involved in Ca++-dependent exocytosis of synaptic vesicles and dense core granules. NCS-1 also functions in the voltage-independent autocrine pathway that negatively regulates non-L-type Ca++ channels.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1199R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1199R-HRP
Lokale Artikelnummer::
BOSSBS-1199R-HRP
Beschreibung:
This protein is a transcriptional activator. It may play a role in the formation of segmented structures of the embryo. May play an important role in the normal development of the vertebral column (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13114R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13114R-FITC
Lokale Artikelnummer::
BOSSBS-13114R-FITC
Beschreibung:
ETV3L is a transcriptional regulator, which belongs to the ETS family and contains 1 ETS DNA-binding domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5194R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5194R
Lokale Artikelnummer::
BOSSBS-5194R
Beschreibung:
AKT, also known as protein kinase B (PKB), is a 57 kDa serine/threonine protein kinase. There are three mammalian isoforms of Akt: AKT1 (PKB alpha), AKT2 (PKB beta) and AKT3 (PKB gamma) with AKT2 and AKT3 being approximately 82% identical with the AKT1 isoform. Each isoform has a pleckstrin homology (PH)domain, a kinase domain and a carboxy terminal regulatory domain. AKT was originally cloned from the retrovirus AKT8, and is a key regulator of many signal transduction pathways. Its tight control over cell proliferation and cell viability are manifold; overexpression or inappropriate activation of AKT has been seen in many types of cancer. AKT mediates many of the downstream events of phosphatidylinositol 3 kinase (a lipid kinase activated by growth factors, cytokines and insulin). PI3 kinase recruits AKT to the membrane, where it is activated by PDK1 phosphorylation. Once phosphorylated, AKT dissociates from the membrane and phosphorylates targets in the cytoplasm and the cell nucleus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11309R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11309R
Lokale Artikelnummer::
BOSSBS-11309R
Beschreibung:
The testis spermatocyte apoptosis-related gene 2 protein (TSARG2, also designated spermatogenesis associated-4 or SPATA4) is involved in spermatogenesis. TSARG2 is specifically expressed in spermatogonia and spermatocytes of the seminiferous tubules, and it localizes to the nucleus. The predicted molecular weight of TSARG2 ranges depending on the species. TSARG2 is significantly upregulated in cryptorchidism and therefore, is a testis-specific apoptosis candidate oncogene.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9614R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9614R-A750
Lokale Artikelnummer::
BOSSBS-9614R-A750
Beschreibung:
Chromosome 14 contains about 700 genes and 106 million base pairs and makes up about 3.5% of human cellular DNA. Chromosome 14 encodes the presinilin 1 (PSEN1) gene, which is one of the three key genes associated with the development of Alzheimer's disease. The SERPINA1 gene is located on chromosome 14 and when defective leads to the genetic disorder antitrypsin deficiency. This disorder is characterised by severe lung complications and liver dysfunction. Notably, the immunoglobulin heavy chain locus is found on chromosome 14 and has been identified as a fusion with the chromosome 19 encoded protein BCL3 in the (14;19) translocations found in a variety of B cell malignancies. The C14orf140 gene product has been provisionally designated C14orf140 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9749R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9749R-A750
Lokale Artikelnummer::
BOSSBS-9749R-A750
Beschreibung:
ANKRD32.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10433R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10433R-FITC
Lokale Artikelnummer::
BOSSBS-10433R-FITC
Beschreibung:
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity). Isoforms 2 to 7 do not bind PGF2-alpha but are proposed to modulate signaling by participating in variant receptor complexes; heterodimers between isoform 1 and isoform 5 are proposed to be a receptor for prostamides including the synthetic analog bimatoprost.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11466R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11466R-A555
Lokale Artikelnummer::
BOSSBS-11466R-A555
Beschreibung:
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8341R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8341R-CY7
Lokale Artikelnummer::
BOSSBS-8341R-CY7
Beschreibung:
CPXM (carboxypeptidase X, member 1) belongs to the peptidase M14 family. However, no carboxypeptidase activity has yet been detected. It may be involved in cell-cell interactions.Members of the M14 metallocarboxypeptidase protein family serve many diverse functions and are divided into three subfamilies based on structure, function and amino acid sequence similarity. Belonging to the N/E subfamily, CPXM (metallocarboxypeptidase CPX-1) is a 734 amino acid protein that contains a F5/8 type C domain and likely binds one zinc ion per subunit. Most members of the N/E subfamily contain several domains, including an active carboxypeptidase domain and signal peptide, and are thought to function mostly in protein-protein interactions and/or protein-membrane interactions, thereby targeting the protein to specific locations within the secretory pathway. CPXM is a unique member of this subfamily in that it does not appear to exhibit any enzymatic activity due to lack of several active-site residues that are present in the catalytic domain of other members of the N/E subfamily. Studies showing that CPXM expression is regulated during osteoclastogenesis suggest that CPXM may play a role in osteoclast differentiation. There are two isoforms of CPXM which are a result of alternative splicing events.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5590R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5590R-A350
Lokale Artikelnummer::
BOSSBS-5590R-A350
Beschreibung:
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2242R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2242R-A647
Lokale Artikelnummer::
BOSSBS-2242R-A647
Beschreibung:
Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5651R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5651R-FITC
Lokale Artikelnummer::
BOSSBS-5651R-FITC
Beschreibung:
The Raf family of serine/threonine specific kinases is comprised of three members (aRaf, bRaf, and cRaf) that play a critical role in regulating cell growth and differentiation, and couple growth factor receptor stimulation to nuclear transcription factors via the Ras/mitogen activated protein kinase (MAPK) pathway. cRaf kinase (also known as Raf1) is a small GTPase like kinase of 73 kDa, and is a signal transducer of multiple extracellular stimuli that is regulated by several pathways, and that once activated, phosphorylates MEK which in turn phosphorylates ERK. Raf1 is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. It is part of the Ras dependent signaling pathway from receptors to the nucleus.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3872R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3872R-CY7
Lokale Artikelnummer::
BOSSBS-3872R-CY7
Beschreibung:
Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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