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BIOSS INC
Artikel-Nr:
(BOSSBS-1517R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1517R-A750
Lokale Artikelnummer::
BOSSBS-1517R-A750
Beschreibung:
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1627R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1627R-HRP
Lokale Artikelnummer::
BOSSBS-1627R-HRP
Beschreibung:
cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9524R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9524R-A680
Lokale Artikelnummer::
BOSSBS-9524R-A680
Beschreibung:
PIGA belongs to the glycosyltransferase 1 family and is necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis. Defects in PIGA are the cause of paroxysmal nocturnal hemoglobinuria (PNH) which is an acquired hemolytic blood disorder characterised by chronic hemolysis with hemoglobinuria, increased tendency to venous thrombosis, and variable degrees of bone marrow failure.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6416R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6416R-A680
Lokale Artikelnummer::
BOSSBS-6416R-A680
Beschreibung:
C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates. Derived from proteolytic degradation of complement C3, C3a anaphylatoxin is a mediator of local inflammatory process. In chronic inflammation, acts as a chemoattractant for neutrophils (By similarity). It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. C3-beta-c: Acts as a chemoattractant for neutrophils in chronic inflammation. Acylation stimulating protein: adipogenic hormone that stimulates triglyceride (TG) synthesis and glucose transport in adipocytes, regulating fat storage and playing a role in postprandial TG clearance. Appears to stimulate TG synthesis via activation of the PLC, MAPK and AKT signaling pathways. Ligand for C5AR2. Promotes the phosphorylation, ARRB2-mediated internalisation and recycling of C5AR2 (PubMed:837664, PubMed:29953, PubMed:959512, PubMed:1432298, PubMed:15833747, PubMed:16333141, PubMed:1961575).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6551R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6551R-A680
Lokale Artikelnummer::
BOSSBS-6551R-A680
Beschreibung:
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene cause progressive encephalopathy resulting from mitochondrial complex I deficiency.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12231R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12231R-A750
Lokale Artikelnummer::
BOSSBS-12231R-A750
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. As a member of the krueppel C2H2-type zinc-finger protein family, ZNF619 (Zinc finger protein 619) is a 560 amino acid nuclear protein that contains ten C2H2-type zinc fingers. The gene encoding ZNF619 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6389R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6389R-A750
Lokale Artikelnummer::
BOSSBS-6389R-A750
Beschreibung:
E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of PCNP. May participate in methylation-dependent transcriptional regulation. Important for G1/S transition. Overexpression causes G1 phase cell arrest.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15440R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15440R-A647
Lokale Artikelnummer::
BOSSBS-15440R-A647
Beschreibung:
HEATR5A.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6048R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6048R-A488
Lokale Artikelnummer::
BOSSBS-6048R-A488
Beschreibung:
May function actively to stimulate axon fasciculation. Induces compartmentalized signaling within a caveolae-like membrane microdomain when bound to the extracellular domain of its cognate receptor. This signaling event requires the activity of the Fyn tyrosine kinase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15297R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15297R-A488
Lokale Artikelnummer::
BOSSBS-15297R-A488
Beschreibung:
C8orf58 (chromosome 8 open reading frame 58) is a 365 amino acid protein that exists as two alternatively spliced isoforms, which are encoded by a gene that maps to human chromosome 8p21. Consisting of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and are typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12473R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12473R-CY5
Lokale Artikelnummer::
BOSSBS-12473R-CY5
Beschreibung:
The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5935R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5935R-CY5
Lokale Artikelnummer::
BOSSBS-5935R-CY5
Beschreibung:
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15450R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15450R-A555
Lokale Artikelnummer::
BOSSBS-15450R-A555
Beschreibung:
May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8062R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8062R-HRP
Lokale Artikelnummer::
BOSSBS-8062R-HRP
Beschreibung:
Involved in vesicular transport in the osteoclast (By similarity). May have a role in sialyl-lex-mediated transduction of apoptotic signals.Tissue specificity: Expressed in placenta, liver, prostate, thymus, spleen, ovary, colon, colon carcinoma and peripheral blood lymphocytes (PBL). Weakly expressed in brain, lung, kidney, and testis. No expression in heart, skeletal muscle, pancreas and small intestine. Predominantly expressed in the breast carcinoma cell line MCF-7.Involvement in disease:Defects in PLEKHM1 are the cause of osteopetrosis autosomal recessive type 6 (OPTB6); also known as autosomal recessive osteopetrosis intermediate form. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. Autosomal recessive osteopetrosis is usually associated with normal or elevated amount of non-functional osteoclasts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1434R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1434R
Lokale Artikelnummer::
BOSSBS-1434R
Beschreibung:
Anti-IGFBP3 Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8198R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8198R-A647
Lokale Artikelnummer::
BOSSBS-8198R-A647
Beschreibung:
[FUNCTION] Seems to enhance replication of some viruses, including yellow fever virus, in response to type I interferon.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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