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BIOSS INC
Artikel-Nr:
(BOSSBS-1402R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1402R-A750
Lokale Artikelnummer::
BOSSBS-1402R-A750
Beschreibung:
Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway. Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3'). Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3'). Isoform SREBP-1A is much more active than isoform SREBP-1C in stimulating transcription from SRE-1-containing promoters. [SUBUNIT] Forms a tight complex with SCAP in the ER membrane. Efficient DNA binding of the soluble transcription factor fragment requires dimerization with another bHLH protein. Interacts with LMNA. [SUBCELLULAR LOCATION] Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle, COPII-coated vesicle membrane; Multi-pass membrane protein. Note=Moves from the endoplasmic reticulum to the Golgi in the absence of sterols. [SUBCELLULAR LOCATION] Processed sterol regulatory element-binding protein 1: Nucleus. Belongs to the SREBP family.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1206R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1206R-A750
Lokale Artikelnummer::
BOSSBS-1206R-A750
Beschreibung:
Acts as a transcriptional activator. May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling and thus cell proliferation and differentiation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1428R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1428R-A647
Lokale Artikelnummer::
BOSSBS-1428R-A647
Beschreibung:
Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15552R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15552R-A750
Lokale Artikelnummer::
BOSSBS-15552R-A750
Beschreibung:
This gene was first identified as one of the many genes induced by interferon. The encoded protein may play a critical role in the regulation of apoptosis. A minisatellite that consists of 26 repeats of a 12 nucleotide repeating element resembling the mammalian splice donor consensus sequence begins near the end of the second exon. Alternatively spliced transcript variants that encode different isoforms by using the two downstream repeat units as splice donor sites have been described.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8474R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8474R-A750
Lokale Artikelnummer::
BOSSBS-8474R-A750
Beschreibung:
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13590R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13590R-A750
Lokale Artikelnummer::
BOSSBS-13590R-A750
Beschreibung:
ITPase (inosine triphosphate pyrophosphatase) is also known as putative oncogene protein hlc14-06-p or ITPA (inosine triphosphatase (nucleoside triphosphate pyrophosphatase)) and is a 194 amino acid protein. ITPase is abundantly expressed in heart, liver, sex glands, thyroid and adrenal gland, and is localized to the cytoplasm in the cell. ITPase catalyzes the pyrophosphohydrolysis of both ITP (inosine triphosphate) and dITP (deoxyinosine triphosphate) to IMP (inosine monophosphate) and diphosphate. IMP can be used as a substrate for purine nucleotide pathways. IMP can be phosphorylated to ITP, and ITPase can regulate the concentration of ITP in the cell by converting ITP back to IMP. Defects in ITPase result in ITPase deficiency which is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9190R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9190R-A750
Lokale Artikelnummer::
BOSSBS-9190R-A750
Beschreibung:
Schlafen family members are preferentially expressed in lymphoid tissues and are differentially regulated during thymocyte maturation. Schlafen proteins function as suppressors of cell growth and are thought to play a role in the maintenance of T cell quiescence. The prototype member of the Schlafen family, Slfn1, is transcriptionally unregulated during thymocyte positive selection, and the induction of Slfn1 induces a G0/G1 arrest, suggesting that Slfn1 participates in the regulation of cell cycle and potentially acts as a determining factor for apoptosis. These proteins all contain a largely conserved core domain within the center of the sequence, and yet they are substantially diversified at the N terminus. Slfn14 (Schlafen family member 14) is a 912 amino acid protein belonging to the Schlafen family. Slfn14 exists as two alternatively spliced isoforms and is encoded by a gene mapping to human chromosome 17q12.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11901R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11901R-A555
Lokale Artikelnummer::
BOSSBS-11901R-A555
Beschreibung:
The helix-loop-helix (HLH) structures are known motifs commonly found in membrane-active and DNA-binding proteins. The helix-loop-helix proteins HEN1 and HEN2 are DNA-binding proteins that may be involved in cell-type determination in the early nervous system. Studies of expression in normal tissues have demonstrated expression of NHLH1/NSCL-1 and NHLH2/NSCL-2, the genes encoding HEN1 and HEN2, in the developing central and peripheral nervous system, specifically in developing neurons.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6231R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6231R-FITC
Lokale Artikelnummer::
BOSSBS-6231R-FITC
Beschreibung:
MAGEF1 is a member of the MAGE (melanoma antigen gene) superfamily.Most known members of the MAGE superfamily are expressed in tumors, testis and fetal tissues, which has been described as a cancer/testis or "CT" expression pattern. MAGEF1, however, is expressed in all adult and fetal tissues tested, as well as in many tumor types including ovarian, breast, cervical, melanoma and leukemia. The coding region of MAGE-F1 is contained within a single exon and includes a microsatellite repeat. Several MAGE genes are ubiquitously expressed suggesting a role for MAGE encoded proteins in normal cell physiology.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0725R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0725R-CY5
Lokale Artikelnummer::
BOSSBS-0725R-CY5
Beschreibung:
Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3 (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7551R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7551R-A555
Lokale Artikelnummer::
BOSSBS-7551R-A555
Beschreibung:
ABIN-3 is a member of the A20-binding inhibitor of NF-kappaB activation (ABIN) protein family. Similar to the previously characterized human ABINs (ABIN-1 and ABIN-2), ABIN-3 can bind to A20 and inhibit NF-kappaB activation. In contrast, mouse ABIN-3 is incapable of inhibiting NF-kappaB activation by proinflammatory stimuli because the protein lacks a complete ABIN homology domain, which is required for the funcitonal activity of human ABIN-3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3886R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3886R-A750
Lokale Artikelnummer::
BOSSBS-3886R-A750
Beschreibung:
NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15194R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15194R-HRP
Lokale Artikelnummer::
BOSSBS-15194R-HRP
Beschreibung:
Representing approximately 6% of the human genome, chromosome 4 contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is on chromosome 4. FGFR-3 is also encoded on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acidemia and polycystic kidney disease. Chromosome 4 reportedly contains the largest gene deserts (regions of the genome with no protein encoding genes) and has one of the two lowest recombination frequencies of the human chromosomes. The C4orf46 gene product has been provisionally designated C4orf46 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2531R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2531R-A680
Lokale Artikelnummer::
BOSSBS-2531R-A680
Beschreibung:
Has a tumor-suppressor role for NES1 in breast and prostate cancer.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2490R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2490R-A680
Lokale Artikelnummer::
BOSSBS-2490R-A680
Beschreibung:
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2456R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2456R-A680
Lokale Artikelnummer::
BOSSBS-2456R-A680
Beschreibung:
Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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