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PROSCI
Artikel-Nr:
(PRSI6093)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6093
Lokale Artikelnummer::
PRSI6093
Beschreibung:
ZIP7 Antibody: The zinc transporter ZIP7, also known as SLC39A7, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP7 was initially identified while characterizing genes in the major histocompatibility complex on chromosome 17. ZIP7 mRNA is abundantly and widely expressed and the protein localizes to the Golgi apparatus. It functions to transport intracellular zinc from the Golgi apparatus to the cytoplasm of the cell. ZIP7 expression is expressed by zinc. ZIP7 has been suggested to act a hub for tyrosine kinase activation and may thus be a potential therapeutic target for diseases such as cancer where prevention of tyrosine kinase activation would be advantageous.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI79-456)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-456
Lokale Artikelnummer::
PRSI79-456
Beschreibung:
Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and enhances suppression of cellular proliferation.
VE:
1 * 100 µG
Artikel-Nr:
(PRSIXP-5168)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
XP-5168
Lokale Artikelnummer::
PRSIXP-5168
Beschreibung:
L13 inhibits proinflammatory cytokine production and stimulates antibody production. It induces proliferation in the human pre myeloid cell line TF1. IL13 has multiple effects on the differentiation and functions of monocytes and macrophages. It suppresses cytotoxic functions and induces changes in the morphology of human monocytes and in the phenotype of human monocytes and B cells by upregulating MHC class II expression. IL13 will also decrease the production of nitric oxide by activated murine macrophages, leading to impaired parasiticidal activity. Human and mouse interleukin 13 share approximately 58% amino acid sequence identity. Although human and mouse IL13 are equally active on human cells, human IL13 is much less active than mouse IL13 on mouse cells. Human IL13 and human IL4 also share approximately 30% sequence homology and have similar biological functions.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI27-168)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-168
Lokale Artikelnummer::
PRSI27-168
Beschreibung:
CPE is a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteinsThis gene encodes a carboxypeptidase that cleaves C-terminal amino acid residues and is involved in the biosynthesis of peptide hormones and neurotransmitters, including insulin. It is a peripheral membrane protein. The protein specifically binds regulated secretory pathway proteins, including prohormones, but not constitutively secreted proteins. Mutations in this gene are implicated in type II diabetes. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI79-592)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-592
Lokale Artikelnummer::
PRSI79-592
Beschreibung:
Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1
VE:
1 * 100 µG
Artikel-Nr:
(PRSI27-995)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-995
Lokale Artikelnummer::
PRSI27-995
Beschreibung:
In infectious mononucleosis, anti-EBNA-1 antibodies are produced which cross-react with multiple normal human proteins. The cross-reactivity is due to anti-gly/ala antibodies that cross-react with host proteins containing configurations like those in the EBNA-1 repeat. One such antigen is RALY which is a member of the heterogeneous nuclear ribonucleoprotein gene family.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI19-887)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
19-887
Lokale Artikelnummer::
PRSI19-887
Beschreibung:
Anti-HELLS Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Artikel-Nr:
(PRSI28-997)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-997
Lokale Artikelnummer::
PRSI28-997
Beschreibung:
BRD7 is an activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. It induces dephosphorylation of GSK3B at 'Tyr-216'.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI31-125)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
31-125
Lokale Artikelnummer::
PRSI31-125
Beschreibung:
APBA1 is a member of the X11 protein family. It is a neuronal adaptor protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilises APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. APBA1 is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI42-919)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
42-919
Lokale Artikelnummer::
PRSI42-919
Beschreibung:
Anti-SLC5A1 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI31-229)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
31-229
Lokale Artikelnummer::
PRSI31-229
Beschreibung:
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. More specifically, it may function in fertility, embryo viability, and regulation of hematopoietic lineage commitment.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI31-296)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
31-296
Lokale Artikelnummer::
PRSI31-296
Beschreibung:
The specific function of the protein remains unknown.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI31-002)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
31-002
Lokale Artikelnummer::
PRSI31-002
Beschreibung:
CFLAR might contribute to the carcinogenesis and aggressiveness of endometrial carcinoma and might be a useful prognostic factor in the tumor. CFLAR is specially overexpressed in colon cancers and it might contribute to carcinogenesis of normal colonic mucosa.
VE:
1 * 100 µG
Artikel-Nr:
(PRSIXP-5183)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
XP-5183
Lokale Artikelnummer::
PRSIXP-5183
Beschreibung:
Interleukin 2 (IL2) is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. IL2 has been shown to have antitumor effects in some studies. This is probably mediated by cytotoxic effector cells.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI48-251)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
48-251
Lokale Artikelnummer::
PRSI48-251
Beschreibung:
Prostaglandin E Receptor EP2 is a member of the Prostanoid Receptor subfamily. Along with several other receptor subtypes (EP1, EP3, and EP4), it mediates the diverse biological effects of Prostaglandin E2 (PGE2). PGE2 has been implicated in numerous processes, including immune response modulation, male erectile function, induction of labor, cervical cancer, control of blood pressure, asthma, and more recently, Alzheimer's Disease.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI7001P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
7001P
Lokale Artikelnummer::
PRSI7001P
Beschreibung:
RGS22 peptide is used for blocking the activity of RGS22 antibody.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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