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PROSCI
Artikel-Nr:
(PRSI45-708)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
45-708
Lokale Artikelnummer::
PRSI45-708
Beschreibung:
Anti-GNRHR Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSIXW-8087)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
XW-8087
Lokale Artikelnummer::
PRSIXW-8087
Beschreibung:
SH3GL1 may play a regulatory role in synaptic vesicle recycling. It interacts with SYNJ1 and DNM1 through its SH3 domain with the proline-rich region of mixed lineage Leukemia (MLL) in either the fusion or the normal MLL protein. This protein is located in cytoplasmic, and peripheral membrane protein associated with internal membranes. Concentrated in presynaptic nerve terminals in neurons (By similarity). It’s expressed ubiquitously. Higher expression in pancreas, placenta, prostate, testis and uterus. In some cases of acute leukemia, a translocation results in the formation of a MLL-EEN fusion gene.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI32-149)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
32-149
Lokale Artikelnummer::
PRSI32-149
Beschreibung:
The transcription factor ELK1 is a family of member of ETS oncogene family and of the ternary complex factor (TCF) subfamily,which is located on chromosome Xp11.2 and stimulates transcription. binds to purine-rich DNA sequences. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum reponse element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Elk1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C terminus,It appears to be a direct target of activated MAP kinase. Biochemical studies indicate that Elk1 is a good substrate for MAP kinase, the kinetics of Elk1phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block Elk1 activation in vivo. More recent studies have shown that Elk1 is also a target of the Stress Activated Kinase SAPK/JNK. Phosphorylation of Elk1 has also been implicated in synaptic plasticity in the adult hippocampus.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI28-039)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-039
Lokale Artikelnummer::
PRSI28-039
Beschreibung:
PAX9 is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of the paired box gene 9 is unknown but it may involve development of stratified squamous epithelia as well as various organs and skeletal elements.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI28-727)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-727
Lokale Artikelnummer::
PRSI28-727
Beschreibung:
SSX2 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t (X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t (X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity. Two transcript variants encoding distinct isoforms have been identified for this gene.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI28-556)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
28-556
Lokale Artikelnummer::
PRSI28-556
Beschreibung:
ZBP1 encodes a Z-DNA binding protein. Z-DNA formation is a dynamic process, largely controlled by the amount of supercoiling.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI29-121)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-121
Lokale Artikelnummer::
PRSI29-121
Beschreibung:
NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. NR1I2 contains a zinc finger domain.NR1I2 is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. NR1I2 belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain.The gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. The gene product contains a zinc finger domain. Three alternatively spliced transcripts that encode different isoforms have been described, one of which encodes two products through the use of alternative translation initiation codons. Additional transcript variants derived from alternative promoter usage, alternative splicing, and/or alternative polyadenylation exist, but they have not been fully described.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI46-980)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
46-980
Lokale Artikelnummer::
PRSI46-980
Beschreibung:
Anti-CDK10 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI23-475)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
23-475
Lokale Artikelnummer::
PRSI23-475
Beschreibung:
Anti-ALOXE3 Rabbit Polyclonal Antibody
VE:
1 * 50 µl
New Product
Artikel-Nr:
(PRSI92-504)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-504
Lokale Artikelnummer::
PRSI92-504
Beschreibung:
Human Glutathione S-transferase P (GSTP1) is an enzyme that in humans is encoded by the GSTP1 gene, belongs to the GST superfamily. It contains 1 GST C-terminal domain, 1 GST N-terminal domain, conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Besides, it regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI34-167)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
34-167
Lokale Artikelnummer::
PRSI34-167
Beschreibung:
It recognises a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. It is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased likelihood of response to endocrine therapy.
VE:
1 * 100 µG
New Product
Artikel-Nr:
(PRSI76-035)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
76-035
Lokale Artikelnummer::
PRSI76-035
Beschreibung:
The 2D10.4 antibody reacts with human CD80, also known as B7-1, a 55 kDa type I transmembrane protein ligand for CD152 (CTLA-4) and for CD28, a co-stimulatory receptor for the T cell receptor (TCR). CD28 also binds a second B7 ligand known as CD86 (B7-2). Both CD80 and CD86 are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction/co-stimulatory signaling between the B7 ligands and CD28 or CTLA-4 provides crucial communication between T cells and B cells or APCs to coordinate the adaptive immune response.
VE:
1 * 0,5 mg
New Product
Artikel-Nr:
(PRSI90-508)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-508
Lokale Artikelnummer::
PRSI90-508
Beschreibung:
Interleukin-21 (IL-21) is a key factor in the transition between innate and adaptive immune responses secreted by activated T cells. The IL-21 receptor (IL-21R) is expressed in lymphoid tissue, in particular by NK, B, T and dendritic cells, macrophages and endothelial cells. Recent evidence suggests that IL-21 plays a supportive role in the proliferation of T and B cells and influences the cytolytic activity of natural killer cells. IL-21 has been shown to up-regulate genes associated with innate immunity and to inhibit the differentiation of naive T helper cells. IL-21 specifically inhibits IFN-gamma production from developing TH1 cells and is preferentially expressed by TH2 cells. Furthermore IL-21 has been identified as a growth and survival factor for human myeloma cells. IL-21/IL-21R interactions have a unique role in sequentially activating both innate and adaptive immune responses against poorly immunogenic tumours, leading to tumour rejection that is perforin dependent but IFN-gamma independent.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI27-926)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
27-926
Lokale Artikelnummer::
PRSI27-926
Beschreibung:
MLL4 a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. MLL4 is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer
VE:
1 * 100 µG
Artikel-Nr:
(PRSI35-271)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
35-271
Lokale Artikelnummer::
PRSI35-271
Beschreibung:
Anti-HIV Goat Polyclonal Antibody (HRP (Horseradish Peroxidase))
VE:
1 * 1 mL
Artikel-Nr:
(PRSI3645)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3645
Lokale Artikelnummer::
PRSI3645
Beschreibung:
TLR3 Antibody: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded (ds) RNA, a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as Influenza A and West Nile Virus and can mediate entry of at least West Nile Virus.
VE:
1 * 100 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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