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8 899 results were found
Proteine und Peptide
Artikel-Nr:
(PRSI91-437)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-437
Lokale Artikelnummer::
PRSI91-437
Beschreibung:
Lysosomal Associated Membrane Protein 2 (LAMP2) is a major component of lysosomal membranes. LAMP2 is a transmembrane glycoprotein about 110kDa. Mature human LAMP2 consists of a 347 amino acid (aa) intralumenal domain, a 24 aa transmembrane segment, and a 35 aa cytoplasmic tail . The lumenal domain is organized into two heavily N-glycosylated regions. Alternate splicing generates a human LAMP2 isoform (LAMP2B) with a substituted juxtamembrane lumenal region, cytoplasmic tail and transmenmbrane segment.LAMP2 itself can cleavage lysosomal luminal domain and degradation lysosomal. In the help of chaperone HSC73,LAMP2 mediates the lysosomal uptake in complex with cargo proteins and is required for the lysosomal destruction of autophagic vacuoles.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-546)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-546
Lokale Artikelnummer::
PRSI91-546
Beschreibung:
Serum Amyloid A1 Protein (SAA1) is an acute phase apolipoprotein reactant that is produced predominantly by hepatocytes and is under the regulation of inflammatory cytokines. SAA is produced mainly in the liver and circulates in low levels in the blood. SAA may play a role in the immune system and facilitate the repair of injured tissues, it also acts as an antibacterial agent, and signals the migration of germ-fighting cells to sites of infection. SAA also functions as an apolipoprotein of the HDL complex. The SAA cleavage product designated amyloid protein A is deposited systemically as amyloid in vital organs such as the liver, spleen, and kidneys in chronic inflammatory diseases patients. These deposits are extremely insoluble and resistant to proteolysis; they disrupt tissue structure and compromise performance.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-213)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-213
Lokale Artikelnummer::
PRSI92-213
Beschreibung:
Copine-1(CPNE1) encodes a calcium-dependent protein which belongs to the copine family. CPNE1contains two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. However, CPNE1 does not contain a predicted signal sequence or transmembrane domains. CPNE1 may regulate molecular events at the interface of the cell membrane and cytoplasm. CPNE1 has a broad tissue distribution and it may function in membrane trafficking.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI40-592)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
40-592
Lokale Artikelnummer::
PRSI40-592
Beschreibung:
GDF-3 is a member of the TGF-β superfamily of growth and differentiation factors, and is highly homologous to GDF-9. Unlike most TGF-β family members, GDF-3 and GDF-9 are not disulfide-linked dimers. GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue. The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes. Recombinant human GDF-3 is a 26.0 kDa non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains.
VE:
1 * 20 µG
Artikel-Nr:
(PRSI96-482)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-482
Lokale Artikelnummer::
PRSI96-482
Beschreibung:
Protein jagged-1 (JAG1) is also known as Jagged1, hJ1, JAGL1 and CD339, which is a single-pass type I membrane protein containing one DSL domain and 15 EGF-like domains. JAG1 is widely expressed in adult and fetal tissues,the expression of JAG1 is up-regulated in cervical squamous cell carcinoma and also expressed in bone marrow cell line HS-27a.JAG1 is a ligand for multiple Notch receptors and involved in the mediation of Notch signaling. JAG1 is involved in early and late stages of mammalian cardiovascular development. JAG1 inhibits myoblast differentiation by similarity and enhances fibroblast growth factor-induced angiogenesis (in vitro).
VE:
1 * 50 µG
Artikel-Nr:
(PRSIXW-RP3204)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
XW-RP3204
Lokale Artikelnummer::
PRSIXW-RP3204
Beschreibung:
This protein is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI5993P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5993P
Lokale Artikelnummer::
PRSI5993P
Beschreibung:
KPNA7 peptide is used for blocking the activity of KPNA7 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI4477P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4477P
Lokale Artikelnummer::
PRSI4477P
Beschreibung:
Slitrk5 peptide is used for blocking the activity of Slitrk5 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-257)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-257
Lokale Artikelnummer::
PRSI90-257
Beschreibung:
izTRAIL is a newly available, highly active recombinant form of soluble human TRAIL. Due to a trimerizing N-terminal isoleucine zipper (iz) motif the intrinsic trimerization of TRAIL, required for apoptosis-inducing activity of TRAIL, is enhanced when compared to non-tagged soluble human TRAIL (shTRAIL). Therefore, izTRAIL is a potent inducer of apoptosis in many human cancer cells, but not normal human hepatocytes. In addition, the half-life of izTRAIL is about eight-fold higher than the half-life of shTRAIL. These properties render izTRAIL highly suitable for both in vitro and in vivo use, particularly for studies in which investigators plan to transfer their in vitro results into an in vivo system with human cancer cells in xenotransplant settings examining susceptibility to TRAIL-induced apoptosis.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI3039P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3039P
Lokale Artikelnummer::
PRSI3039P
Beschreibung:
AATF peptide is used for blocking the activity of AATF antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-247)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-247
Lokale Artikelnummer::
PRSI90-247
Beschreibung:
Netrin-1 controls guidance of CNS commissural axons and peripheral motor axons. Its association with either DCC or some UNC5 receptors will lead to axon attraction or repulsion, respectively. It also serve as a survival factor via its association with its receptors which prevent the initiation of apoptosis. Netrin-1 is also Involved in tumorigenesis by regulating apoptosis.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI2337P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2337P
Lokale Artikelnummer::
PRSI2337P
Beschreibung:
IKAP peptide is used for blocking activity of IKAP antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5875P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5875P
Lokale Artikelnummer::
PRSI5875P
Beschreibung:
HVCN1 peptide is used for blocking the activity of HVCN1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-294)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-294
Lokale Artikelnummer::
PRSI90-294
Beschreibung:
BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. Processed human BAFF can either remain as a trimer, which is usual for TNF family ligands or assemble into 60-mer composed of 20 trimers. Mouse BAFF 60-mer has been identified in the serum of BAFF transgenic mice. Oligomerisation of BAFF 3-mer into 60-mer in human BAFF is prevented by mutation of His218, a residue critical for 3-mer-to-3-mer interactions, but not for receptor binding. Despite the predominant functional role of processed BAFF in vivo, membrane-bound BAFF might also play a role. Indeed, soluble BAFF (3-mer) can trigger BAFF-R but not TACI or BCMA, whereas oligomeric forms of BAFF (BAFF 60-mer), which mimic membrane-bound BAFF, activate all BAFF receptors.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI96-377)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-377
Lokale Artikelnummer::
PRSI96-377
Beschreibung:
Influenza, commonly known as "the flu", is an infectious disease of birds and mammals caused by RNA viruses of the family Orthomyxoviridae, the influenza viruses. The virus is divided into three main types (Influenzavirus A, Influenzavirus B, and Influenzavirus C), which are distinguished by differences in two major internal proteins (hemagglutinin (HA) and neuraminidase (NA), which are the most important targets for the immune system. The type A viruses are the most virulent human pathogens among the three influenza types and cause the most severe disease. The serotypes that have been confirmed in humans, ordered by the number of known human pandemic deaths, are: H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, H10N7, H7N9. H7N9 is a serotype of the species Influenzavirus A (avian influenza virus or bird flu virus). H7 normally circulates amongst avian populations with some variants known to occasionally infect humans. An H7N9 virus was first reported to have infected humans in 2013 in China.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4081P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4081P
Lokale Artikelnummer::
PRSI4081P
Beschreibung:
BRSK1 peptide is used for blocking the activity of BRSK1 antibody.
VE:
1 * 50 µG
Preis auf Anfrage
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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