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Proteine und Peptide
Artikel-Nr:
(PRSI92-493)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-493
Lokale Artikelnummer::
PRSI92-493
Beschreibung:
Thrombopoietin (TPO) is a glycoprotein hormone which belongs to the EPO/TPO family. It produced by the liver and kidney which regulates the production of platelets. TPO stimulates the production and differentiation of megakaryocytes, the bone marrow cells that bud off large numbers of platelets. Lineage-specific cytokine affects the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-677)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-677
Lokale Artikelnummer::
PRSI91-677
Beschreibung:
Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only. Inhibins/activins regulates many physiological processes, such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth and so on.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-485)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-485
Lokale Artikelnummer::
PRSI91-485
Beschreibung:
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-154)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-154
Lokale Artikelnummer::
PRSI90-154
Beschreibung:
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signalling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI91-154)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-154
Lokale Artikelnummer::
PRSI91-154
Beschreibung:
Stathmin (STMN1) is a ubiquitous cytosolic phosphoprotein which belongs to the Stathmin family. STMN1 is expressed in many tissues, with the highest expression in the brain, spinal cord, and cerebellum. It can also be expressed in the colon, ovary, placenta, uterus, and trachea. STMN1 participates in the regulation of the microtubule filament structure by destabilizing microtubules. STMN1 promotes the disassembly of microtubules and prevents assembly. STMN1 is involved in the control of the learned and innate fear. STMN1 is an intracellular relay integrating regulatory signals of the cellular environment and as an Oncoprotein in regulation of the cell cycle. Phosphorylation at Ser-16 may be required for axon formation during neurogenesis. Mutation in STMN1 effects cell homeostasis that may lead to tumorigenicity.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-005)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-005
Lokale Artikelnummer::
PRSI92-005
Beschreibung:
WW Domain-Binding Protein 1 (WBP1) is widely expressed in many tissues, but it is lowly expressed in the lung, placenta, kidney, and liver. WBP1 contains two WW-binding motifs: WW-binding 1 and WW-binding 2 that are involved in mediating protein-protein interactions through the binding of polyproline ligands. The WW-binding domain is composed of 38 to 40 semi-conserved amino acids shared by proteins with diverse functions including structural, regulatory, and signaling proteins. In addition, WBP1 also encodes a ligand of the WW domain of the Yes kinase-associated protein. This function has not been determined.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI2479P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2479P
Lokale Artikelnummer::
PRSI2479P
Beschreibung:
MCG10 peptide is used for blocking the activity of MCG10 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-075)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-075
Lokale Artikelnummer::
PRSI92-075
Beschreibung:
Interferon Regulatory Factor 5 (IRF5) is a member of the IRF family. It contains one IRF tryptophan pentad repeat DNA-binding domain. IRF5 shuttles between the nucleus and the cytoplasm. IRF5 can form homodimer when it is phosphorylated. IRF5 functions as a transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Genetic variations in IRF5 are associated with susceptibility to systemic lupus erythematosus type 10. In addition, the genetic variations wil result in susceptibility to rheumatoid arthritis.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-095)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-095
Lokale Artikelnummer::
PRSI90-095
Beschreibung:
FGF-21 (Fibroblast growth factor 21) stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of betaKlotho.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-314)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-314
Lokale Artikelnummer::
PRSI90-314
Beschreibung:
Cochlin is an extracellular matrix protein expressed in the cochlea and vestibule of the inner ear. Mutations in the cochlin gene are linked to the autosomal-dominant DFNA9 syndrome, a disorder characterised by hearing loss. Cochlin is also expressed in follicular dendritic cells of the spleen and the lymph nodes. The N-terminus of cochlin contains a LCCL domain also present in Factor C, a serine protease of the horseshoe crab Limulus, involved in activating the coagulation cascade in response to LPS. A recent study showed that in response to inflammation, LPS or bacterial infection, cochlin is cleaved by the proteases aggrecanases and secreted into blood circulation. The secreted cochlin (LCCL domain) seems to have a role in local cytokine production, recruitment of immune effector cells and bacterial clearance. Cochlin is secreted as two forms p8 and p18, whereas p18 being the glycosylated form of p8.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI96-503)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-503
Lokale Artikelnummer::
PRSI96-503
Beschreibung:
Lysosomal-associated membrane protein 1 (LAMP1) is also known as CD107a (Cluster of Differentiation 107a). LAMP1 / CD107a belongs to the LAMP family. This glycoprotein provides selectins with carbohydrate ligands. It may also play a role in tumor cell metastasis. CD107a has also been shown to be a marker of degranulation on lymphocytes such as CD8+ and NK cells.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI92-570)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-570
Lokale Artikelnummer::
PRSI92-570
Beschreibung:
Ectodysplasin A receptor (EDAR) is a type I transmembrane protein of the TNF- alpha receptor superfamily which plays a key role in ectodermal differentiation. EDAR was encoded by the mouse down less gene and defective in human dominant and recessive forms of autosomal hypo hidrotic ectodermal dysplasia (EDA) syndrome. The extracellular domain of EDAR contains 14 cysteine residues, six of which approximate the TNFRSF cysteine-rich region, the cytoplasmic domain contains a region with homology to the death domains found in other TNFRSF members. EDAR has been suggested to be an early and important promoter of placode development in all ectodermal organs, such as uch as hair follicles, teeth and sweat glands. EDA-A1, the A1 isoform of EDA, is the EDAR ligand. EDA and EDA are implicated in appendage development by the cloning of a gene underlying hypo hidrotic ectodermal dysplasia (HED) in mouse and human. HED is Characterised by agenesis or malformation of ectoderm-derived appendages, such as teeth, sweat glands and hair follicles, while the skin itself develops normally.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-472)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-472
Lokale Artikelnummer::
PRSI90-472
Beschreibung:
Interleukin-4 (IL-4) is a cytokine produced by type 2 helper T cells, the Th2 cells. These cells tends to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). In addition, mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunoglobulin class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. IL-4 promotes survival, growth, and differentiation of both T and B lymphocytes, mast cells and endothelial cells. In addition, IL-4 inhibits the production of TNF, IL-1, and IL-6 by macrophages.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI92-509)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-509
Lokale Artikelnummer::
PRSI92-509
Beschreibung:
Fibroblast growth factor 8 (FGF8) is a member of the fibroblast growth factor family. It is discovered as a growth factor essential for the androgen-dependent growth of mouse mammary carcinoma cells. Mouse FGF8b shares 100% aa identity with human FGF8b. FGF8 is widely expressed during embryogenesis, and mediates epithelial-mesenchymal transitions. It plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. It is required for normal brain, eye, ear, limb development during embryogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-427)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-427
Lokale Artikelnummer::
PRSI96-427
Beschreibung:
Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.
VE:
1 * 200 µG
Artikel-Nr:
(PRSI92-242)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-242
Lokale Artikelnummer::
PRSI92-242
Beschreibung:
Disks large homolog 4(DLG4) is a cell membrane protein and it is a member of the membrane-associated guanylate kinase (MAGUK) family. The protein contains 1 guanylate kinase-like domain，3 PDZ (DHR) domains and 1 SH3 domain. With PSD-93 it is recruited into the same NMDA receptor and potassium channel clusters. These two MAGUK proteins may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. DLG4 is the best studied member of the MAGUK-family of PDZ domain-containing proteins. Like all MAGUK-family proteins, its basic structure includes three PDZ domains, an SH3 domain, and a guanylate kinase-like domain (GK) connected by disordered linker regions. It is almost exclusively located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins. Its direct and indirect binding partners include neuroligin, NMDA receptors, AMPA receptors, and potassium channels.
VE:
1 * 50 µG
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