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Proteine und Peptide
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Interleukin 2 (IL-2) is an immunomodulatory cytokine that is produced by lymphocytes. IL-2 signals through the IL-2R receptor to induce activated T cell proliferation and promote T cell differentiation. IL-2 also stimulates the proliferation and differentiation of B cells, natural killer cells, monocytes, and macrophages.
Artikel-Nr:
(PRSI92-201)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-201
Lokale Artikelnummer::
PRSI92-201
Beschreibung:
Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitisation and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF19 can be considered as a regulator of energy expenditure.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI2465P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2465P
Lokale Artikelnummer::
PRSI2465P
Beschreibung:
IL-21 peptide is used for blocking the activity of IL-21 antibody.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Interleukin 4 (IL-4) is an immunomodulatory cytokine that functions to induce naive helper T cells to differentiate into type 2 T helper (Th2) cells. Th2 cells subsequently produce more IL-4 in a positive feedback loop. IL-4 also promotes immunoglobulin IgG to IgE isotype switching on B cells. IL-4 binds the IL-4Rα receptor to activate STAT6 signaling.
Lieferant:
Shenandoah Biotechnology
Beschreibung:
CD40 ligand (CD40L) or CD154 is a membrane glycoprotein and differentiation antigen that is expressed on the surface of T cells, monocytes, basophils, eosinophils, platelets, dendritic cells, and endothelial cells.
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Activin A is a member of the transforming growth factor beta (TGF-β) family of proteins and functions to stimulate follicle-stimulating hormone (FSH) secretion. Activins are produced in many tissue types including the skin, gonads, lungs, and pituitary gland. Activins interact with receptor type I and type II serine/threonine protein kinases, to activate SMAD signaling and regulate diverse cellular functions, such as cell proliferation, differentiation, wound healing, apoptosis, and metabolism. Activin A is a homodimer comprised of two activin βA chains. Cleavage of the N-terminal propeptide renders the Activin protein biologically active. Human Activin A shares 100% amino acid sequence identity with mouse, rat, porcine, bovine, and feline Activin A proteins.
Artikel-Nr:
(PRSI2493P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
2493P
Lokale Artikelnummer::
PRSI2493P
Beschreibung:
The peptide is used for blocking the activity of KappaB ras-1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-902)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-902
Lokale Artikelnummer::
PRSI91-902
Beschreibung:
Endothelial Cell Adhesion Molecule (ESAM) is a 55 kDa type I transmembrane glycoprotein member of the JAM family of immunoglobulin superfamily molecules. The 390 amino acid Human ESAM contains a 216 amino acid extracellular domain (ECD) with a V-type and a C2-type immunoglobulin (Ig) domain. ESAM is specifically expressed at endothelial tight junctions and on activated platelets and performs homophilic adhesion activity. The adaptor protein membrane-associated guanylate kinase MAGI-1 has been identified as an intracellular binding partner of ESAM. In addition, ESAM at endothelial tight junctions participates in the migration of neutrophils through the vessel wall, possibly by influencing endothelial cell contacts. ESAM-deficient mice were described with lowered angiogenic potential, and accordingly, overexpression of ESAM is closely associated with certain tumor growth and metastasis. ESAM is expressed on endothelial cells, activated platelets and megakaryocytes. The ECD of human and mouse ESAM share 69% amino acid identity.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-182)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-182
Lokale Artikelnummer::
PRSI92-182
Beschreibung:
Ankyrin repeat and SOCS box protein 13(ASB13) is a member of the ankyrin repeat and SOCS box-containing (ASB) family. ASB13 contain six ankyrin repeats sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. ASB13 may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-604)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-604
Lokale Artikelnummer::
PRSI92-604
Beschreibung:
Wnt signaling plays a critical role in embryonic development, and genetic aberrations. Frizzled2 (Fzd2) is a receptor for wingless-type MMTV integration site family members (Wnts), the aberrant overexpression of which has been noted to contribute to cancer metastasis. Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade tumors and that their expression correlates with markers of epithelial-mesenchymal transition (EMT). It is also shown that Frizzled-2 expression is greater in embryonic than adult tissues, with heart, brain, lung, kidney and gut showing the highest levels.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5991P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5991P
Lokale Artikelnummer::
PRSI5991P
Beschreibung:
KPNA6 peptide is used for blocking the activity of KPNA6 antibody.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Interleukin 6 (IL-6) is a cytokine that is expressed by T cells, macrophages, and muscle cells. IL-6 acts to stimulate an immune response upon infection or trauma. IL-6 has both pro-inflammatory and anti-inflammatory functions, is capable of promoting fever, and signals through the cell-surface type I cytokine receptor complex containing the IL-6Ra and gp130 chains.
Artikel-Nr:
(PRSI90-076)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-076
Lokale Artikelnummer::
PRSI90-076
Beschreibung:
The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signalling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI90-375)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-375
Lokale Artikelnummer::
PRSI90-375
Beschreibung:
Butyrophilin-like 2 (BTNL2) is a butyrophilin family member with homology to the B7 costimulatory molecules, polymorphisms of which have been recently associated through genetic analysis; to sporadic inclusion body myositis and sarcoidosis. BTNL2 mRNA is highly expressed in lymphoid tissues as well as in intestine. BTNL2-Ig fusion protein was shown to recognize a putative receptor whose expression on B and T cells was significantly enhanced after activation. It inhibited T cell proliferation and TCR activation of NFAT, NF-kappaB and AP-1 signalling pathways. BTNL2 is the first member of the butyrophilin family that regulates T cell activation, which has implications in immune diseases and immunotherapy.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI90-253)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-253
Lokale Artikelnummer::
PRSI90-253
Beschreibung:
Angiocidin shows sequence similarity with proteasome components and is also being referred to as 26A proteasome regulatory subunit S5A. Angiocidin shows both matrix and cytoplasmic distribution. It binds to thrombospondin-1 and alpha2beta1 integrin, and it inhibits tumour progression and angiogenesis. Angiocidin is expressed in various types of cancer, such as hepatocellular carcinoma, prostate, lung, bladder, and melanoma cancers.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI91-366)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-366
Lokale Artikelnummer::
PRSI91-366
Beschreibung:
The protein acid protease active in intracellular protein breakdown and involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease. It is specificity similar to, but narrower than, that of pepsin A and it does not cleave the 4-Gln-|-His-5 bond in B chain of insulin. It consists of a light chain and a heavy chain and expressed in the aorta extrcellular space. The Val-58 allele is significantly overrepresented in demented patients (11.8%) compared with non-demented controls (4.9%). Carriers of the Val-58 allele have a 3.1-fold increased risk for developing AD than non-carriers.It belongs to the peptidase A1 family
VE:
1 * 50 µG
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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