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4,4-Difluorocyclohexaneethanamine
Artikel-Nr:
(BOSSBS-9520R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9520R-A350
Lokale Artikelnummer::
BOSSBS-9520R-A350
Beschreibung:
Dyrk (for dual specificity tyrosine phosphorylation regulated kinase) is the homolog of the Drosophila mnb (minibrain) gene, which is required for neurogenesis. Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation. Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases. Dyrk family members, including Dyrk1A (originally Dyrk), Dyrk1B, Dyrk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions. Two isoforms of human fetal brain Dyrk2 exist: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the amino terminus. Dyrk3 is strongly expressed in testis, only after the onset of spermatogenesis, and very weakly expressed in spleen and adrenal gland. The genes which encode Dyrk2 and Dyrk3 map to human chromosomes 12 and 1q32, respectively.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11877R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11877R-CY7
Lokale Artikelnummer::
BOSSBS-11877R-CY7
Beschreibung:
The leucine-rich (LRR) repeat is a 20-30 amino acid motif that forms a hydrophobic Alpha/Beta horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. The LRRTM protein family plays a role in the regulation of various cellular events during nervous system development. Localizing predominantly to the nervous system, LRRTM family members are known to exhibit synaptogenic activity. LRRTM2 (leucine rich repeat transmembrane neuronal 2), also known as LRRN2, is a 516 amino acid single-pass type I membrane protein involved in the development maintenance of the vertebrate nervous system. Expressed in kidney and neuronal tissues, LRRTM2 contains ten LRR repeats and belongs to the LRRTM family. LRRTM2 is encoded by a gene that maps to human chromosome 5q31.2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9394R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9394R-A680
Lokale Artikelnummer::
BOSSBS-9394R-A680
Beschreibung:
WD-repeats are motifs that are found in a variety of proteins and are characterised by a conserved core of 40-60 amino acids that commonly form a tertiary propeller structure. While proteins that contain WD-repeats participate in a wide range of cellular functions, they are generally involved in regulatory mechanisms concerning chromatin assembly, cell cycle control, signal transduction, RNA processing, apoptosis and vesicular trafficking. WDR40A (WD-repeat-containing protein 40A), also known as DDB1- CUL4-associated factor 12, is a 453 amino acid cytoplasmic protein that contains four WD-repeats. WDR40A is highly expressed in some cancer cell lines, lung cancer tissues and normal testis. A probable substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex, WRD40A is suggested to interact with DDB1. WDR40A is encoded by a gene mapping to human chromosome 9p13.3. Human chromosome 9 houses over 900 genes and comprises nearly 4% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11604R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11604R-CY7
Lokale Artikelnummer::
BOSSBS-11604R-CY7
Beschreibung:
Na+/Cl- dependent neurotransmitter transporters are a superfamily of transmembrane proteins that contain 12 membrane spanning regions (1). Specifically, the highly hydrophobic Na+/Cl- dependent glycine transporters (GlyT) are crucial for the termination of neurotransmission at glycinergic synapses (2,3). Two different GlyT genes encode GlyT2 and GlyT1, which exists as two isoforms produced by alternative splicing of the same gene located on human chromosome 1p31.3 (3,4). The GlyT1 gene may be an early marker of neural development and encodes glia-specific transporter proteins (3). Although GlyT1 and GlyT2 are both expressed in the brain and spinal cord, each shows a unique pattern of expression (3,5,6). GlyT1 is found only in the white matter of the CNS, whereas GlyT2 is found in the gray matter of the CNS as well as in macrophages and mast cells in peripheral tissues (3,5). The anatomic distribution of GlyT2 mRNA suggests that glycine may act as a supraspinal neurotransmitter and may function as a chemical messenger outside the CNS (5).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11956R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11956R-A680
Lokale Artikelnummer::
BOSSBS-11956R-A680
Beschreibung:
The leucine-rich (LRR) repeat is a 20 to 30 amino acid motif that forms a hydrophobic å/ horseshoe fold, allowing it to accommodate several leucine residues within a tightly packed core. All LRR repeats contain a variable segment and a highly conserved segment, the latter of which accounts for 11 or 12 residues of the entire LRR motif. SLITRK3 (SLIT and NTRK-like family, member 3) is a 977 amino acid single-pass type I membrane protein that contains 20 LRR repeats and belongs to the SLITRK family. Expressed at highest levels in cerebral cortex, SLITRK3 is also found in adult and fetal neural tissues and some astrocytic brain tumours. SLITRK3 functions to suppress neurite outgrowth and plays a role in the regulation of neuronal function. SLITRK3 is encoded by a gene that maps to human chromosome 3, which houses over 1100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11604R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11604R-CY5
Lokale Artikelnummer::
BOSSBS-11604R-CY5
Beschreibung:
Na+/Cl- dependent neurotransmitter transporters are a superfamily of transmembrane proteins that contain 12 membrane spanning regions (1). Specifically, the highly hydrophobic Na+/Cl- dependent glycine transporters (GlyT) are crucial for the termination of neurotransmission at glycinergic synapses (2,3). Two different GlyT genes encode GlyT2 and GlyT1, which exists as two isoforms produced by alternative splicing of the same gene located on human chromosome 1p31.3 (3,4). The GlyT1 gene may be an early marker of neural development and encodes glia-specific transporter proteins (3). Although GlyT1 and GlyT2 are both expressed in the brain and spinal cord, each shows a unique pattern of expression (3,5,6). GlyT1 is found only in the white matter of the CNS, whereas GlyT2 is found in the gray matter of the CNS as well as in macrophages and mast cells in peripheral tissues (3,5). The anatomic distribution of GlyT2 mRNA suggests that glycine may act as a supraspinal neurotransmitter and may function as a chemical messenger outside the CNS (5).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13202R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13202R
Lokale Artikelnummer::
BOSSBS-13202R
Beschreibung:
Xenopus winged-helix factor, xFAST-1 (forkhead activin signal transducer-1) is a transcription factor that forms a complex with the receptor-regulated Smad protein, Smad2, and directly binds to activin response elements on DNA (1,2). The human homolog FAST-1 and the corresponding mouse homolog, designated FAST-2, share significant sequence homology with xFAST-1, including a conserved N-terminal forkhead domain that consists of 110 amino acid residues and is essential for binding DNA and regulating transcription in embryogenesis, in tumorigenesis and in the maintenance of differentiated cell states (3,4). FAST-1 and FAST-2 also contain a distinct C-terminal Smad interaction domain that is required for the association with various Smad proteins, including Smad2, Smad3 and Smad4 (3,5). Expression of FAST-1 and FAST-2 is predominantly observed during early development, with lower levels detected in adult tissues (6,7). FAST-1 and FAST-2 mediated DNA binding is attenuated by both TFGß and activin, indicating that these FAST proteins mediate TFGß induced signal transduction (3).
VE:
1 * 100 µl
Artikel-Nr:
(HECH42815248)
Lieferant:
GLASWARENFABRIK KARL HECHT
Hersteller-Artikelnummer::
42815248
Lokale Artikelnummer::
HECH42815248
Beschreibung:
Racks, made of plastic coated wire, ideally used for test tubes or centrifuge tubes.
VE:
1 * 1 ST
Artikel-Nr:
(BOSSBS-15154R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15154R-CY7
Lokale Artikelnummer::
BOSSBS-15154R-CY7
Beschreibung:
C12orf56 (chromosome 12 open reading frame 56), also known as PRO1853 or protein midA homolog, is a 441 amino acid mitochondrial protein that belongs to the midA family. Existing as two alternatively spliced isoforms, C12orf56 is encoded by a gene that maps to human chromosome 2p22.2. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstr syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15154R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15154R
Lokale Artikelnummer::
BOSSBS-15154R
Beschreibung:
C12orf56 (chromosome 12 open reading frame 56), also known as PRO1853 or protein midA homolog, is a 441 amino acid mitochondrial protein that belongs to the midA family. Existing as two alternatively spliced isoforms, C12orf56 is encoded by a gene that maps to human chromosome 2p22.2. As the second largest human chromosome, chromosome 2 makes up approximately 8% of the human genome and contains 237 million bases encoding over 1,400 genes. A number of genetic diseases are linked to genes on chromosome 2. Harlequin icthyosis, a rare skin deformity, is associated with mutations in the ABCA12 gene. The lipid metabolic disorder sitosterolemia is associated with ABCG5 and ABCG8. An extremely rare recessive genetic disorder, Alstré°‰ syndrome, is related to mutations in the ALMS1 gene. Chromosome 2 contains a probable vestigial second centromere as well as vestigial telomeres, which gives credence to the hypothesis that human chromosome 2 formed as a result of an ancient fusion of two ancestral chromosomes, which are still present in modern day apes.
VE:
1 * 100 µl
Artikel-Nr:
(L16588.06)
Lieferant:
Alfa Aesar
Hersteller-Artikelnummer::
L16588.06
Lokale Artikelnummer::
ALFAL16588.06
Beschreibung:
1H,1H,12H,12H-Eicosafluor-1,12-dodecandiol tech. 90%, technische Qualität
VE:
1 * 5 g
Artikel-Nr:
(MOLE10908583-25G)
Lieferant:
Molekula
Hersteller-Artikelnummer::
10908583-25G
Lokale Artikelnummer::
MOLE10908583-25G
Beschreibung:
o-Phenylendiacetonitril
VE:
1 * 25 g
 This is a MarketSource item. Additional charges may apply
Artikel-Nr:
(PROOHXC001)
Lieferant:
LGC Standards PROMOCHEM
Hersteller-Artikelnummer::
HXC001
Lokale Artikelnummer::
PROOHXC001
Beschreibung:
4-Chlorbrenzcatechin
VE:
1 * 1 g
Artikel-Nr:
(BOSSBS-12332R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12332R-A350
Lokale Artikelnummer::
BOSSBS-12332R-A350
Beschreibung:
Dyrk is the homolog of the Drosophila mnb (minibrain) gene, which is required for neurogenesis (1–3). Dyrk is a dual-specificity tyrosine kinase and serine/threonine kinase, which is itself regulated by tyrosine phosphorylation (1). Several mammalian Dyrk related proteins have been identified and are thought to compose a family of dual specificity protein kinases (4). Dyrk family members, including Dyrk1A (originally Dyrk), Dyrk1B, Dryk1C, Dyrk2, Dyrk3, Dyrk4A and Dyrk4B, are thought to be involved in diverse cellular functions (4). Dyrk1A is a candidate gene that may be involved in Downs syndrome, and it has been found to be somewhat overexpressed in Downs syndrome (1,5). Two isoforms of human fetal brain Dyrk2 exist: a deduced 528-amino acid protein and a protein containing 73 additional amino acids at the amino terminus (4). Dyrk3 is strongly expressed in testis, only after the onset of spermatogenesis, and very weakly expressed in spleen and adrenal gland (1). The genes which encode Dyrk2 and Dyrk3 map to human chromosomes 12 and 1q32, respectively (4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11769R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11769R-A488
Lokale Artikelnummer::
BOSSBS-11769R-A488
Beschreibung:
The majority of mitochondrial-directed proteins are encoded by the nuclear genome and are transported to the mitochondria via regulated processes involving the mitochondrial Tom and Tim proteins (1). The mitochondrial Tim protein family is comprised of a large group of evolutionarily conserved proteins that are found in most eukaryotes (1,2). Import of nuclear-encoded precursor proteins into and across the mitochondrial inner membrane is mediated by two distinct complexes, the Tim23 complex and the Tim22 complex, which differ in their substrate specificity (1). Defects in Tim proteins are implicated in several neuro-degenerative diseases, suggesting important roles for Tim proteins in development and health (3,4). Tim8A and Tim8B, which map to human chromosomes Xq22.1 and 11q23.1-q23.2, respectively, are conserved proteins of the mitochondrial intermembrane space, which are organized in hetero-oligomeric complex with Tim13 (5,6,7). Tim8A is highly expressed in fetal and adult brain (5). Tim8A is mutated in deafness dystonia syndrome, a novel type of disease that causes severe neurological defects, thought to be caused by a defective mitochondrial protein transport system (5,8).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11512R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11512R-A350
Lokale Artikelnummer::
BOSSBS-11512R-A350
Beschreibung:
Bardet-Biedl syndrome (BBS) is a pleiotropic genetic disorder characterized by obesity, photoreceptor degeneration, polydactyly, hypogenitalism, renal abnormalities, and developmental delay. Other associated clinical findings in BBS patients include diabetes, hypertension, and congenital heart defects. BBS genes map to multiple loci and encode fourteen proteins, BBS1-BBS14. Many BBS genes encode basal body or cilia proteins, suggesting that BBS is a ciliary dysfunction disorder. BBS10 (Bardet-Biedl syndrome 10), also known as chromosome 12 open reading fame 58, C12orf58 or FLJ23560, is a novel 723 amino acid protein belonging to the TCP-1 chaperonin family. BBS10 localizes to the basal body of primary cilium and assists in protein folding upon ATP hydrolysis. Inhibition of BBS10 has been found to impair ciliogenesis, activate the glycogen synthase kinase 3 pathway and cause peroxisome proliferator-activated receptor nuclear accumulation. The gene encoding BBS10 contains two exons and maps to human chromosome 12q21.2.
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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