5-Chloronaphthalene-2-sulphonyl+chloride
Lieferant:
Biotium
Beschreibung:
This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.
Lieferant:
Biotium
Beschreibung:
This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.
Lieferant:
Biotium
Beschreibung:
This MAb reacts with an N-terminal epitope (aa 16-25) of both wild type and mutated p53. Mutation and/or allelic loss of p53 is one of the causes of a variety of mesenchymal and epithelial tumors. If it occurs in the germ line, such tumors run in families. In most transformed and tumor cells the concentration of p53 is increased 51000 fold over the minute concentrations (1000 molecules cell) in normal cells, principally due to the increased half-life (4 h) compared to that of the wild-type (20 min). p53 Localizes in the nucleus, but is detectable at the plasma membrane during mitosis and when certain mutations modulate cytoplasmic/nuclear distribution. Mutations arise with an average frequency of 70% but incidence varies from zero in carcinoid lung tumors to 97% in primary melanomas. High concentrations of p53 protein are transiently expressed in human epidermis and superficial dermal fibroblasts following mild ultraviolet irradiation. Positive nuclear staining with p53 antibody has been reported to be a negative prognostic factor in breast carcinoma, lung carcinoma, colorectal, and urothelial carcinoma. Anti-p53 positivity has also been used to differentiate uterine serous carcinoma from endometrioid carcinoma as well as to detect intratubular germ cell neoplasia.
Artikel-Nr:
(FLUO003625-25G)
Lieferant:
FLUOROCHEM
Hersteller-Artikelnummer::
003625-25G
Lokale Artikelnummer::
FLUO003625-25G
Beschreibung:
EEDQ (Ethyl-N-(2-ethoxy-1,2-dihydrochinolin)carboxylat)
VE:
1 * 25 g
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Artikel-Nr:
(24901-25MG)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
24901-25MG
Lokale Artikelnummer::
SUPL24901-25MG
Beschreibung:
Ionophore employed in solvent polymeric membrane electrodes for the assay of Cl- activity.
VE:
1 * 25 mg
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
Bromthymolblau Natriumsalz
Artikel-Nr:
(SIAL415456-5ML)
Lieferant:
Sigma-Aldrich
Hersteller-Artikelnummer::
415456-5ML
Lokale Artikelnummer::
SIAL415456-5ML
Beschreibung:
1,2-Dichlor-1,1,2,2-tetramethyldisilan, Sigma-Aldrich®
VE:
1 * 5 mL
Artikel-Nr:
(MOLEM10325546)
Lieferant:
Molekula
Hersteller-Artikelnummer::
M10325546
Lokale Artikelnummer::
MOLEM10325546
Beschreibung:
EEDQ (Ethyl-N-(2-ethoxy-1,2-dihydrochinolin)carboxylat)
VE:
1 * 25 g
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Lieferant:
Sigma-Aldrich
Beschreibung:
1,2-Epoxy-5-hexen, Sigma-Aldrich®
Lieferant:
Thermo Scientific
Beschreibung:
Xylenolorange Tetranatriumsalz, wasserlöslich, rein
Lieferant:
COMBI-BLOCKS
Beschreibung:
3,6-Dibromimidazo[1,2-a]pyridin
Lieferant:
COMBI-BLOCKS
Beschreibung:
6-Bromimidazo[1,2-a]pyridin Hydrochlorid
Lieferant:
COMBI-BLOCKS
Beschreibung:
3-Brom-7-methylimidazo[1,2-a]pyridin
Artikel-Nr:
(COBBHC-6661-1G)
Lieferant:
COMBI-BLOCKS
Hersteller-Artikelnummer::
HC-6661-1G
Lokale Artikelnummer::
COBBHC-6661-1G
Beschreibung:
6-Chlorimidazo[1,2-a]pyridin-3-carbaldehyd
VE:
1 * 1 g
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Lieferant:
Sigma-Aldrich
Beschreibung:
1,2-Bis(dimethylamino)methan, Sigma-Aldrich®
Preis auf Anfrage
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