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3-(1-Adamantyl)propanoic+acid
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3-(1-Adamantyl)propanoic+acid
Lieferant:
Hach
Beschreibung:
Diese digitalen Kombinationselektroden verfügen über einen integrierten Temperaturfühler und sind entweder nachfüllbar oder nicht nachfüllbar. Sie können mit allen Hach HQd™ Messgeräten verwendet werden.
Artikel-Nr:
(590-0036)
Lieferant:
VWR Collection
Lokale Artikelnummer::
VWRI590-0036
Beschreibung:
Lösungsmittel oder mobile Phasen werden sicher aus Reservoirs und Flaschen extrahiert, ohne sich schädlichen Gasen und Lösungsmitteldämpfen auszusetzen. Hochwertige Materialien (PTFE und PP) gewährleisten maximale Sicherheit für Ihr Laborpersonal und die Umwelt.
VE:
1 * 1 ST
Lieferant:
VARIAN
Beschreibung:
Solid Phase Extraction (SPE) plate, SPEC 96-well plate, Ionenaustauschsorbentien, SCX, 15 mg
Artikel-Nr:
(PEAK3300670)
Lieferant:
PEAK SCIENTIFIC INSTRUMENTS
Hersteller-Artikelnummer::
3300670
Lokale Artikelnummer::
PEAK3300670
Beschreibung:
Peak scientific’s Solaris XE nitrogen generator offers a reliable, compressor-free gas solution that can comfortably meet the demands of most mass spectrometers within Waters’ portfolio of instruments. Using our tried and tested membrane technology, Solaris XE can operate with varying flow rates (up to 35 L/min of high purity nitrogen), purity (up to 99,5%) and outlet pressure can be adjusted down from 8 bar.
VE:
1 * 1 ST
Lieferant:
MP Biomedicals
Beschreibung:
Ethylenediaminetetraacetic Acid Trisodium Salt Hydrate White Crystalline Powder
Artikel-Nr:
(PRSI91-233)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-233
Lokale Artikelnummer::
PRSI91-233
Beschreibung:
Peptidyl-Prolyl Cis-Trans Isomerase H (PPIH) belongs to the Cyclophilin-type PPIase family that accelerate the folding of proteins. PPIases can catalyze the cis-trans isomerisaion of Proline Imidic peptide bonds in oligopeptides. PPIH participates in pre-mRNA splicing. It is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. In addition, PPIH has PPIase activity and may play a role as a chaperone mediating the interactions between different proteins inside the spliceosome.
VE:
1 * 50 µG
Artikel-Nr:
(BOSSBS-5239R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5239R
Lokale Artikelnummer::
BOSSBS-5239R
Beschreibung:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5239R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5239R-CY5.5
Lokale Artikelnummer::
BOSSBS-5239R-CY5.5
Beschreibung:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5239R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5239R-A647
Lokale Artikelnummer::
BOSSBS-5239R-A647
Beschreibung:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5239R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5239R-HRP
Lokale Artikelnummer::
BOSSBS-5239R-HRP
Beschreibung:
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported. Two families of cyclin dependent kinase inhibitors (CKIs) have been identified. The p21WAF1/Cip1 family inhibits all kinases involved in the G1/S transition. The p16INK4a family inhibits Cdk4 and Cdk6 specifically.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0573R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0573R-CY5.5
Lokale Artikelnummer::
BOSSBS-0573R-CY5.5
Beschreibung:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. Transcript Variant: This variant (1) contains a different 5' end region, which includes an upstream in-frame translation start codon, when compared to variant 2. The encoded protein has a 15 aa longer N-terminus, as compared to isoform 2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0802R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0802R-CY3
Lokale Artikelnummer::
BOSSBS-0802R-CY3
Beschreibung:
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0573R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0573R-CY3
Lokale Artikelnummer::
BOSSBS-0573R-CY3
Beschreibung:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. This protein accumulates at the G1-S phase boundary and is degraded as cells progress through S phase. Overexpression of this gene has been observed in many tumors, which results in chromosome instability, and thus may contribute to tumorigenesis. This protein was found to associate with, and be involved in, the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been described. Two additional splice variants were reported but detailed nucleotide sequence information is not yet available. Transcript Variant: This variant (1) contains a different 5' end region, which includes an upstream in-frame translation start codon, when compared to variant 2. The encoded protein has a 15 aa longer N-terminus, as compared to isoform 2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0802R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0802R-CY7
Lokale Artikelnummer::
BOSSBS-0802R-CY7
Beschreibung:
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8.
VE:
1 * 100 µl
Lieferant:
LEICA MICROSYSTEMS
Beschreibung:
Die Mikroskope Leica DM750 wurden speziell entwickelt, um den naturwissenschaftlichen Unterricht zu erleichtern. DM750 ist im Wesentlichen für die vielseitigen Anforderungen fortgeschrittener Kurse in Biowissenschaften und für die Berufsausbildung, beispielsweise an medizinischen, veterinärmedizinischen und zahnmedizinischen Schulen, konzipiert.
Lieferant:
G-Biosciences
Beschreibung:
Tri-Xtract™ is designed for the isolation of total RNA that is free from protein and DNA contamination. The isolated RNA is suitable for Northern blots, dot blot hybridisation, <i>in vitro</i> translation, RNase protection assays and poly (A+) selection.
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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