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Ethyl+5-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxylate
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Ethyl+5-hydroxypyrazolo[1,5-a]pyrimidine-3-carboxylate
Artikel-Nr:
(APOSOR7106-50MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR7106-50MG
Lokale Artikelnummer::
APOSOR7106-50MG
Beschreibung:
[2-(1H-1,2,4-Triazol-1-yl)ethyl]amine hydrochloride 95%
VE:
1 * 50 mg
Artikel-Nr:
(APOSOR110148-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR110148-1G
Lokale Artikelnummer::
APOSOR110148-1G
Beschreibung:
2-Ethyl 7-methyl imidazo[1,2-a]pyridine-2,7-dicarboxylate hydrobromide
VE:
1 * 1 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
4-[4-(2-Hydroxy-ethyl)-piperazin-1-ylmethyl]-benzoic acid methyl ester
Artikel-Nr:
(4992-26)
Lieferant:
MACRON AVANTOR BRAND
Lokale Artikelnummer::
MACR4992-26
Beschreibung:
Ethylacetat ≥99,5% (durch GC, auf Wasserinhalt korrigiert), AR® ACS, Macron Fine Chemicals™
VE:
1 * 200 L
Artikel-Nr:
(BOSSBS-3495R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3495R-A555
Lokale Artikelnummer::
BOSSBS-3495R-A555
Beschreibung:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15482R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15482R-CY5
Lokale Artikelnummer::
BOSSBS-15482R-CY5
Beschreibung:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3495R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3495R-CY3
Lokale Artikelnummer::
BOSSBS-3495R-CY3
Beschreibung:
Serine/threonine protein kinase which is a central regulator of cellular metabolism, growth and survival in response to hormones, growth factors, nutrients, energy and stress signals. MTOR directly or indirectly regulates the phosphorylation of at least 800 proteins. Functions as part of 2 structurally and functionally distinct signaling complexes mTORC1 and mTORC2 (mTOR complex 1 and 2). Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. This includes phosphorylation of EIF4EBP1 and release of its inhibition toward the elongation initiation factor 4E (eiF4E). Moreover, phosphorylates and activates RPS6KB1 and RPS6KB2 that promote protein synthesis by modulating the activity of their downstream targets including ribosomal protein S6, eukaryotic translation initiation factor EIF4B, and the inhibitor of translation initiation PDCD4. Stimulates the pyrimidine biosynthesis pathway, both by acute regulation through RPS6KB1-mediated phosphorylation of the biosynthetic enzyme CAD, and delayed regulation, through transcriptional enhancement of the pentose phosphate pathway which produces 5-phosphoribosyl-1-pyrophosphate (PRPP), an allosteric activator of CAD at a later step in synthesis, this function is dependent on the mTORC1 complex. Regulates ribosome synthesis by activating RNA polymerase III-dependent transcription through phosphorylation and inhibition of MAF1 an RNA polymerase III-repressor. In parallel to protein synthesis, also regulates lipid synthesis through SREBF1/SREBP1 and LPIN1. To maintain energy homeostasis mTORC1 may also regulate mitochondrial biogenesis through regulation of PPARGC1A. mTORC1 also negatively regulates autophagy through phosphorylation of ULK1. Under nutrient sufficiency, phosphorylates ULK1 at 'Ser-758', disrupting the interaction with AMPK and preventing activation of ULK1. Also prevents autophagy through phosphorylation of the autophagy inhibitor DAP.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15482R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15482R-A750
Lokale Artikelnummer::
BOSSBS-15482R-A750
Beschreibung:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome. Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilise XPC. May protect XPC from proteasomal degradation. The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognises a wide spectrum of damaged DNA characterised by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognise and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts.
VE:
1 * 100 µl
Artikel-Nr:
(23570.106)
Lieferant:
VWR Chemicals
Lokale Artikelnummer::
VWRC23570.106
Beschreibung:
Dithizon ≥98,0%, AnalaR NORMAPUR® analytisches Reagens
VE:
1 * 5 g
Artikel-Nr:
(APOSPC430604-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC430604-1G
Lokale Artikelnummer::
APOSPC430604-1G
Beschreibung:
2-(2-(4-(Trifluoromethyl)-2-oxopyrimidin-1(2H)-yl)ethyl)isoindoline-1,3-dione
VE:
1 * 1 g
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
N-[1-(2-Fluorophenyl)ethyl]prop-2-yn-1-amine hydrochloride 92%
Artikel-Nr:
(APOSPC31870-250MG)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
PC31870-250MG
Lokale Artikelnummer::
APOSPC31870-250MG
Beschreibung:
3-(2-Chloro-6-fluorophenyl)-N-(2-{[(fur-2-yl)methyl]sulphanyl}ethyl)-5-methylisoxazole-4-carboxamide
VE:
1 * 250 mg
Lieferant:
Alfa Aesar
Beschreibung:
L-Alanin-ethylester-hydrochlorid ≥98%
Lieferant:
APOLLO SCIENTIFIC
Beschreibung:
3-Oxo-pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-ethyl ester
Artikel-Nr:
(APOSOR22109-1G)
Lieferant:
APOLLO SCIENTIFIC
Hersteller-Artikelnummer::
OR22109-1G
Lokale Artikelnummer::
APOSOR22109-1G
Beschreibung:
4-Benzyl 2-ethyl 3-(2-ethoxy-2-oxoethyl)-5-methyl-1H-pyrrole-2,4-dicarboxylate
VE:
1 * 1 g
Artikel-Nr:
(1.11608.0030)
Lieferant:
Merck
Hersteller-Artikelnummer::
1.11608.0030
Lokale Artikelnummer::
MERC1.11608.0030
Beschreibung:
Ethidiumbromid 10 mg/ml in wässriger Lösung für die Elektrophorese, Sigma-Aldrich®
VE:
1 * 30 mL
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
-Additional Documentation May be needed to purchase this item. A VWR representative will contact you if needed.
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Dieses Produkt ist Ersatz für den von Ihnen gewünschten Artikel.
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