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Ethyl-2-naphthoyl+formate
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Ethyl-2-naphthoyl+formate
Artikel-Nr:
(BOSSBS-10319R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10319R-A680
Lokale Artikelnummer::
BOSSBS-10319R-A680
Beschreibung:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumour suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9460R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9460R-A750
Lokale Artikelnummer::
BOSSBS-9460R-A750
Beschreibung:
Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins which inhibit positive transcription elongation factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit, Cdk9, and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9460R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9460R-HRP
Lokale Artikelnummer::
BOSSBS-9460R-HRP
Beschreibung:
Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins which inhibit positive transcription elongation factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit, Cdk9, and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9460R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9460R-FITC
Lokale Artikelnummer::
BOSSBS-9460R-FITC
Beschreibung:
Hexamethylene bis-acetamide inducible 1 (HEXIM1) and Hexamethylene bis-acetamide inducible 2 (HEXIM2) comprise a family of proteins which inhibit positive transcription elongation factor b (P-TEFb) through association with 7SK. P-TEFb is composed of a catalytic subunit, Cdk9, and either Cyclin T1 or T2 as a regulatory subunit. This complex regulates eukaryotic gene expression at the level of elongation. The C-terminal domains of HEXIM proteins interact directly with each other. Via these domains, HEXIM1 and HEXIM2 form stable homo- and hetero-oligomers, which may aid in the formation of the 7SK small nuclear ribonucleic acid particle. Despite their similar functions, HEXIM1 and HEXIM2 exhibit distinct expression patterns in various established cell lines and human tissues.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7084R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7084R-A680
Lokale Artikelnummer::
BOSSBS-7084R-A680
Beschreibung:
Defects in NOD2 are the cause of sarcoidosis early-onset (EOS) . EOS is a form of sarcoidosis manifesting in children younger than 4 years of age. Sarcoidosis is an idiopathic, systemic, inflammatory disease characterised by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Early-onset sarcoidosis is quite rare and has a distinct triad of skin, joint and eye disorders, without apparent pulmonary involvement. Compared with an asymptomatic and sometimes naturally disappearing course of the disease in older children, early-onset sarcoidosis is progressive and in many cases causes severe complications, such as blindness, joint destruction and visceral involvement.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15131R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15131R-A555
Lokale Artikelnummer::
BOSSBS-15131R-A555
Beschreibung:
Chromosome 22 contains over 500 genes and about 49 million bases. Being the second smallest human chromosome, 22 contains a surprising variety of interesting genes. Phelan-McDermid syndrome, Neurofibromatosis type 2 and autism are associated with chromosome 22. A schizophrenia susceptibility locus has been identified on chromosome 22 and studies show that 22q11 deletion symptoms include a high incidence of schizophrenia. Translocations between chromosomes 9 and 22 may lead to the formation of the Philadelphia Chromosome and the subsequent production of the novel fusion protein, BCR-Abl, a potent cell proliferation activator found in several types of leukemia. The C22orf13 gene product has been provisionally designated C22orf13 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6660R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6660R-A647
Lokale Artikelnummer::
BOSSBS-6660R-A647
Beschreibung:
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C.Tissue specificity; Skeletal muscle, heart, colon, testis, ovary and pancreas.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15047R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15047R-CY3
Lokale Artikelnummer::
BOSSBS-15047R-CY3
Beschreibung:
C1orf187, also known as Draxin, Dorsal repulsive axon guidance protein and Neucrin, is a 349 amino acid secreted protein that is required of the development of the spinal cord and forebrain commissures. C1orf187 acts as a chemorepulsive guidance protein and directs commissural axons during development by repelling neurite outgrowth from the spinal cord. During development, C1orf187 modulates neural crest migration by reducing the polarization of these cells, leading to reduced velocity of migration and increased frequency of changing direction, leading to a net decrease in migrational distance. It acts as an antagonist of the Wnt signaling pathway by inhibiting the stabilization of cytosolic _-catenin via its interaction with LRP6. C1orf187 inhibits outgrowth from the olfactory bulb and likely contributes to the formation of the lateral olfactory tract.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9209R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9209R-CY7
Lokale Artikelnummer::
BOSSBS-9209R-CY7
Beschreibung:
ZPI, also known as SERPINA10 (serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10) or PZI, is a 444 amino acid secreted protein that functions as a Protein Z-dependent protease inhibitor. Expressed by the liver, ZPI is secreted into the plasma where, in the presence of calcium, Protein Z and phospholipids, it inhibits the activated pro-coagulation factors X and XI (Factor X and Factor XI). This inhibition helps properly regulate intravenous blood clotting. ZPI, a member of the serpin protein family, contains five potential N-linked glycosylation sites and a tyrosine at position 387 which, when disrupted, renders ZPI inactive. Defects in the gene encoding ZPI may increase susceptibility to venous thrombosis, the formation of blood clots within a vein.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3465R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3465R
Lokale Artikelnummer::
BOSSBS-3465R
Beschreibung:
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5474R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5474R-CY7
Lokale Artikelnummer::
BOSSBS-5474R-CY7
Beschreibung:
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3603R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3603R-CY5
Lokale Artikelnummer::
BOSSBS-3603R-CY5
Beschreibung:
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6946R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6946R-CY5.5
Lokale Artikelnummer::
BOSSBS-6946R-CY5.5
Beschreibung:
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L (By similarity). Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6946R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6946R-CY5
Lokale Artikelnummer::
BOSSBS-6946R-CY5
Beschreibung:
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L (By similarity). Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8866R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8866R-CY5
Lokale Artikelnummer::
BOSSBS-8866R-CY5
Beschreibung:
Enzymes known as phosphatidylserine decarboxylases (PSDs) catalyze the formation of phosphatidylethanolamine from phosphatidylserine via phosphatidylserine decarboxylation. Type I PSDs contain LGST motifs and are found in bacteria and eukaryotic mitochondria, whereas type II PSDs contain GGST motifs and are found in eukaryotic endomembrane systems. PISD (phosphatidylserine decarboxylase), also known as phosphatidylserine decarboxylase proenzyme, PSDC, PSD, PSSC, DJ858B16, dJ858B16.2 or DKFZp566G2246, is a 408 amino acid a type I phosphatidylserine decarboxylase that localizes to the inner mitochondrial membrane. PISD contains a conserved LGST motif which is cleaved to produce two isoforms known as PISD α and PISD β. PISD is capable of forming a heterodimer and is highly expressed in liver and testis. The gene encoding PISD maps to human chromosome 22q12.2.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5474R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5474R-CY5
Lokale Artikelnummer::
BOSSBS-5474R-CY5
Beschreibung:
The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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