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cis-6-Amino-cyclohex-3-enecarboxylic+acid
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cis-6-Amino-cyclohex-3-enecarboxylic+acid
Artikel-Nr:
(BOSSBS-11708R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11708R-A680
Lokale Artikelnummer::
BOSSBS-11708R-A680
Beschreibung:
ATP13A2 is a 1180 amino acid multi-pass membrane protein that belongs to the P5 subfamily of ATPases which play an important role in the transportation of inorganic cations. Expressed as multiple alternative spliced isoforms, ATP13A2 functions to catalyse the conversion of ATP to ADP and a free phosphate, thereby participating in the active transport of ions across cellular membranes. Defects in the gene encoding ATP13A2 are the cause of Kufor-Rakeb syndrome (KRS), a rare hereditary type of Parkinson's disease that exhibits juvenile onset and is characterised by neurodegeneration and dementia. The ATP13A2 gene maps to human chromosome 1, which spans 260 million base pairs, contains over 3000 genes and comprises nearly 8% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13454R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13454R-CY5
Lokale Artikelnummer::
BOSSBS-13454R-CY5
Beschreibung:
GMEB-1 is a 573 amino acid protein that contains one SAND domain and is a member of the KDWK family of combinatorial transcription modulators. Localized to both the cytoplasm and the nucleus, GMEB-1 forms a heterodimer with GMEB-2 (Glucocorticoid modulatory element-binding protein 2) and, once associated with GMEB-2, plays a key role in parvovirus DNA replication. In addition, GMEB-1 functions alone as a trans-acting factor that, by binding to glucocorticoid modulatory elements (GMEs) in TAT (tyrosine aminotransferase) promoters, increases intracellular sensitivity to glucocorticoid concentrations. GMEB-1 also interacts with initiator procaspases and, via this interaction, can inhibit caspase-induced apoptosis. Due to alternative splicing events, GMEB-1 is expressed as two isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11932R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11932R-CY7
Lokale Artikelnummer::
BOSSBS-11932R-CY7
Beschreibung:
Human Pecanex proteins are homologs of the Drosophila Pecanex protein, a maternal-effect neurogenic protein that is involved in normal development of the fly nervous system. Three human Pecanex homologs exist, designated Pecanex, Pecanex 2, also known as PCNXL2 (pecanex-like 2), and Pecanex 3. Pecanex 2 is a 2,137 amino acid multi-pass membrane protein that exists as five alternatively spliced isoforms characterized by high mutational frequencies and biallelic mutations in colorectal tumors, thereby likely functioning as a target gene in these tumors. Pecanex 2 is encoded by a gene that maps to human chromosome 1q42.2, which is linked to an inherited microduplication. This microduplication that includes Pecanex 2 may play a role in autism and mild mental retardation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11386R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11386R-CY3
Lokale Artikelnummer::
BOSSBS-11386R-CY3
Beschreibung:
AADACL3 is a 350 amino acid protein that belongs to the 'GDXG' lipolytic enzyme family and participates in hydrolase activity. Existing as two alternatively spliced isoforms, AADACL3 is encoded by a gene that maps to human chromosome 1p36.21. Chromosome 1, the largest human chromosome, makes up 8% of the human genome and contains about 260 million base pairs, which encode 3,000 genes. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson’s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12406R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12406R
Lokale Artikelnummer::
BOSSBS-12406R
Beschreibung:
SNX2 and SNX4 share a high degree of amino acid similarity with SNX1, as they all contain a characteristic phox homology (PX) domain (4). These proteins are all partially associated with cellular membranes, and they, likewise, associate with EGF, PDGF and insulin receptor tyrosine kinases (2). These nexins are widely expressed and yet have various tissue distribution patterns. Additionally, the sorting nexins can associate with each other and with a variety of other cellular proteins, suggesting that they exist as part of multisubunit complexes (1,5). The related protein, SNX3, comprises a distinct subgroup of nexins that share less sequence similarity outside of the PX domain and have dramatically different binding affinities for the tyrosine kinase receptors (2,6).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9024R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9024R-A647
Lokale Artikelnummer::
BOSSBS-9024R-A647
Beschreibung:
IQCF1 is an 81 amino acid protein encoded by the IQCF1 gene, which maps to human chromosome 3. Chromosome 3 is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11932R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11932R-CY3
Lokale Artikelnummer::
BOSSBS-11932R-CY3
Beschreibung:
Human Pecanex proteins are homologs of the Drosophila Pecanex protein, a maternal-effect neurogenic protein that is involved in normal development of the fly nervous system. Three human Pecanex homologs exist, designated Pecanex, Pecanex 2, also known as PCNXL2 (pecanex-like 2), and Pecanex 3. Pecanex 2 is a 2,137 amino acid multi-pass membrane protein that exists as five alternatively spliced isoforms characterized by high mutational frequencies and biallelic mutations in colorectal tumors, thereby likely functioning as a target gene in these tumors. Pecanex 2 is encoded by a gene that maps to human chromosome 1q42.2, which is linked to an inherited microduplication. This microduplication that includes Pecanex 2 may play a role in autism and mild mental retardation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11183R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11183R-CY5
Lokale Artikelnummer::
BOSSBS-11183R-CY5
Beschreibung:
Extracellular proteases mediate the digestion of neighboring extracellular matrix components in initial tumor growth, allow desquamation of tumor cells into the surrounding environment, provide the basis for invasion of basement membranes in targeted metastatic organs and are required for release and activation of many growth and angiogenic factors. TMPRSS5 (transmembrane protease, serine 5), also known as spinesin, is a 457 amino acid single-pass type II membrane protein that is expressed specifically in brain and is thought to play a role in hearing. A member of the peptidase S1 family, TMPRSS5 contains one peptidase S1 domain and an SRCR domain, and is encoded by a gene that maps to human chromosome 11q23.2. Defects in the gene encoding TMPRSS5 are associated with deafness.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13454R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13454R-A680
Lokale Artikelnummer::
BOSSBS-13454R-A680
Beschreibung:
GMEB-1 is a 573 amino acid protein that contains one SAND domain and is a member of the KDWK family of combinatorial transcription modulators. Localized to both the cytoplasm and the nucleus, GMEB-1 forms a heterodimer with GMEB-2 (Glucocorticoid modulatory element-binding protein 2) and, once associated with GMEB-2, plays a key role in parvovirus DNA replication. In addition, GMEB-1 functions alone as a trans-acting factor that, by binding to glucocorticoid modulatory elements (GMEs) in TAT (tyrosine aminotransferase) promoters, increases intracellular sensitivity to glucocorticoid concentrations. GMEB-1 also interacts with initiator procaspases and, via this interaction, can inhibit caspase-induced apoptosis. Due to alternative splicing events, GMEB-1 is expressed as two isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9812R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9812R-A680
Lokale Artikelnummer::
BOSSBS-9812R-A680
Beschreibung:
GCF, also known as C2orf3 (chromosome 2 open reading frame 3), transcription factor 9 (TCF-9) or DNABF, is a 781 amino acid nuclear protein that belongs to the GCF family. Widely expressed, GCF binds the GC-rich sequences of -Actin, EGFR and calcium-dependent protease (CANP) promoters. GCF contains multiple phosphoserine and phosphothreonine residues, and two GCF isoforms are produced due to alternative splicing events. GCF is considered a candidate for susceptibility to dyslexia (DYX3) as both genes reside in close proximity on human chromosome 2. Chromosome 2 is the second largest human chromosome and consists of 237 million bases, encodes over 1400 genes and makes up approximately 8% of the human genome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11391R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11391R
Lokale Artikelnummer::
BOSSBS-11391R
Beschreibung:
Alpha-aminoadipic semialdehyde synthase (AASS), also designated lysine ketoglutarate reductase (LKR) or saccharopine dehydrogenase (SDH), is a 926 amino acid protein that exists as a homodimer in the mitochondria. AASS acts as a bifunctional enzyme containing the lysine alpha-ketoglutarate reductase (LKR) and saccharopine dehydrogenase activities that catalyzes the first two steps in lysine degradation. It is widely expressed with highest expression in liver and transcription of the AASS gene is induced upon starvation. Mutations in the gene encoding AASS result in various forms familial hyperlysinemias (FH), autosomal recessive disorders characterized by hyperlysinemia, lysinuria, and variable saccharopinuria. However, no adverse mental or physical effects have been found in patients with hyperlysinemia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13171R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13171R-CY5
Lokale Artikelnummer::
BOSSBS-13171R-CY5
Beschreibung:
The FHAD1 gene encodes a 1,420 amino acid protein and maps to human chromosome 1, the largest human chromosome which spans about 260 million base pairs and makes up 8% of the human genome. Other notable genes located on chromosome 1 include LMNA, which is associated with the rare aging disease Hutchinson-Gilford progeria, and the MUTYH gene, which is partially responsible for familial adenomatous polyposis. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome. A breakpoint has been identified in 1q which disrupts the DISC1 gene and is linked to schizophrenia. Aberrations in chromosome 1 are found in a variety of cancers including head and neck cancer, malignant melanoma and multiple myeloma.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8857R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8857R-CY5
Lokale Artikelnummer::
BOSSBS-8857R-CY5
Beschreibung:
NOB1P is a 412 amino acid nuclear protein that is involved in proteosome biogenesis and is required for the final step in 18S rRNA maturation. NOB1P contains a PIN domain, which functions as a nuclease in nonsense-mediated mRNA decay and is required for pre-rRNA cleavage. NOB1P interacts with Rent2, which is involved in nonsense-mediated decay of mRNAs containing premature stop codons. Expressed in placenta, spleen, endothelial cells, liver and lung, NOB1P is essential for the synthesis of 40S ribosome subunits. Supression of the gene encoding NOB1P inhibits the processing of the 20S pre-rRNA to the mature 18S rRNA, therefore leading to accumulation of high levels of 20S pre-rRNA with degradation intermediates.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12356R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12356R-A680
Lokale Artikelnummer::
BOSSBS-12356R-A680
Beschreibung:
ALX1 is a 326 amino acid protein specific to cervix and cartilage tissues. As well as having a homeobox domain, ALX1 also contains an OAR domain, which has been suggested to be important for DNA binding or protein-protein interactions and transactivation. First characterised from a rat chondrosarcoma tumour cell line, ALX1 is a homeobox transcription factor that regulates downstream target genes and has specifically shown to act as a transcriptional repressor for rat prolactin in vivo. Homozygous ALX1 deficient mice are born with acrania and meroanencephaly, suggesting ALX1 function in the development of the neural tube. It has also been suggested that ALX1 cooperates with ALX4 in limb development and craniofacial bone formation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12223R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12223R-A750
Lokale Artikelnummer::
BOSSBS-12223R-A750
Beschreibung:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Kr_ppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF786 (zinc finger protein 786) is a 782 amino acid protein that belongs to the Kr_ppel C2H2-type zinc-finger protein family and is thought to function in transcriptional regulation. Localizing to nucleus, ZNF786 contains sixteen C2H2-type zinc fingers, a single KRAB domain and is encoded by a gene that maps to human chromosome 7q36.1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11932R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11932R-CY5
Lokale Artikelnummer::
BOSSBS-11932R-CY5
Beschreibung:
Human Pecanex proteins are homologs of the Drosophila Pecanex protein, a maternal-effect neurogenic protein that is involved in normal development of the fly nervous system. Three human Pecanex homologs exist, designated Pecanex, Pecanex 2, also known as PCNXL2 (pecanex-like 2), and Pecanex 3. Pecanex 2 is a 2,137 amino acid multi-pass membrane protein that exists as five alternatively spliced isoforms characterized by high mutational frequencies and biallelic mutations in colorectal tumors, thereby likely functioning as a target gene in these tumors. Pecanex 2 is encoded by a gene that maps to human chromosome 1q42.2, which is linked to an inherited microduplication. This microduplication that includes Pecanex 2 may play a role in autism and mild mental retardation.
VE:
1 * 100 µl
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Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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