Sie suchten nach: ligase

Artikel-Nr: (BOSSBS-5935R-A555)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-5935R-A555

Lokale Artikelnummer:: BOSSBS-5935R-A555

Beschreibung: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5935R-A488)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-5935R-A488

Lokale Artikelnummer:: BOSSBS-5935R-A488

Beschreibung: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9291R-CY5)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9291R-CY5

Lokale Artikelnummer:: BOSSBS-9291R-CY5

Beschreibung: E3 ubiquitin-protein ligase that plays a role in the control of mitochondrial morphology. Promotes mitochondrial fragmentation and influences mitochondrial localization. Inhibits cell growth. When overexpressed, activates JNK through MAP3K7/TAK1 and induces caspase-dependent apoptosis. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugatin.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9249R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9249R-A750

Lokale Artikelnummer:: BOSSBS-9249R-A750

Beschreibung: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9249R-A555)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9249R-A555

Lokale Artikelnummer:: BOSSBS-9249R-A555

Beschreibung: Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Required for poly-ubiquitination and proteasome-mediated degradation of CDKN1B during G1 phase of the cell cycle.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-5931R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-5931R-HRP

Lokale Artikelnummer:: BOSSBS-5931R-HRP

Beschreibung: May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9246R-CY7)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9246R-CY7

Lokale Artikelnummer:: BOSSBS-9246R-CY7

Beschreibung: E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9338R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9338R-HRP

Lokale Artikelnummer:: BOSSBS-9338R-HRP

Beschreibung: MARCH4, an E3 ubiquitin protein ligase, may mediate ubiquitination of MHC I and CD4, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin protein ligases accept ubiquitin from an E2 ubiquitin conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7752R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7752R-HRP

Lokale Artikelnummer:: BOSSBS-7752R-HRP

Beschreibung: KLHL13 (kelch like 13), also known as BKLHD2 (BTB and kelch domain containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate specific adapter of an E3 ubiquitin protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin mediated proteolysis. Via its BTB and C terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL3 ligase.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-7752R-A350)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-7752R-A350

Lokale Artikelnummer:: BOSSBS-7752R-A350

Beschreibung: KLHL13 (kelch like 13), also known as BKLHD2 (BTB and kelch domain containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate specific adapter of an E3 ubiquitin protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin mediated proteolysis. Via its BTB and C terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL3 ligase.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9345R-A680)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9345R-A680

Lokale Artikelnummer:: BOSSBS-9345R-A680

Beschreibung: E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9132R)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9132R

Lokale Artikelnummer:: BOSSBS-9132R

Beschreibung: May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9240R-HRP)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9240R-HRP

Lokale Artikelnummer:: BOSSBS-9240R-HRP

Beschreibung: Ubiquitination is an important mechanism through which three classes of enzymes act in concert to target short-lived or abnormal proteins for destruction. The three classes of enzymes involved in ubiquitination are the ubiquitin-activating enzymes (E1s), the ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s). RNF25 (RING finger protein 25), also known as AO7, is a 459 amino acid protein that contains one RWD domain and one RING-type zinc finger. Via its RING-type zinc finger (a common domain that contains a conserved cysteine-rich region and is found in a number of viral and eukaryotic proteins), RNF25 is thought to exhibit E2-dependent E3 ubiquitin-protein ligase activity. Specifically, the RING finger of RNF25 interacts with an E2 ligase and, through this interaction, facilitates the ubiquitination of target proteins. RNF25 may also regulate the transcriptional activity of NF-kappa-B, a protein that plays important roles in cell survival, inflammation response, host defense and proliferation.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9382R-A647)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9382R-A647

Lokale Artikelnummer:: BOSSBS-9382R-A647

Beschreibung: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9382R-A680)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9382R-A680

Lokale Artikelnummer:: BOSSBS-9382R-A680

Beschreibung: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

VE: 1 * 100 µl

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Artikel-Nr: (BOSSBS-9382R-A750)

Lieferant: Bioss

Hersteller-Artikelnummer:: BS-9382R-A750

Lokale Artikelnummer:: BOSSBS-9382R-A750

Beschreibung: Acts as an E2-dependent E3 ubiquitin-protein ligase, probably involved in the ER-associated protein degradation pathway.

VE: 1 * 100 µl

Sale