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BIOSS INC
Artikel-Nr:
(BOSSBS-3364R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3364R-FITC
Lokale Artikelnummer::
BOSSBS-3364R-FITC
Beschreibung:
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12561R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12561R-FITC
Lokale Artikelnummer::
BOSSBS-12561R-FITC
Beschreibung:
May have a function in cell adhesion and/or receptor signaling.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7726R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7726R-A680
Lokale Artikelnummer::
BOSSBS-7726R-A680
Beschreibung:
Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1927R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1927R-A750
Lokale Artikelnummer::
BOSSBS-1927R-A750
Beschreibung:
Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2503R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2503R-A488
Lokale Artikelnummer::
BOSSBS-2503R-A488
Beschreibung:
This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. With PARP1 and TXK, forms a complex that acts as a T helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15174R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15174R-A750
Lokale Artikelnummer::
BOSSBS-15174R-A750
Beschreibung:
C3orf32 (chromosome 3 open reading frame 32), also known as fls485, is a 353 amino acid protein encoded by a gene that maps to human chromosome 3p26.1. Chromosome 3 is made up of approximately 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth disease are a few of the numerous genetic diseases associated with chromosome 3.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8538R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8538R-A647
Lokale Artikelnummer::
BOSSBS-8538R-A647
Beschreibung:
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9205R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9205R-A680
Lokale Artikelnummer::
BOSSBS-9205R-A680
Beschreibung:
Has glycerophosphoinositol inositolphosphodiesterase activity and specifically hydrolyzes glycerophosphoinositol, with no activity for other substrates such as glycerophosphoinositol 4-phosphate, glycerophosphocholine, glycerophosphoethanolamine, and glycerophosphoserine. Accelerates the program of osteoblast differentiation and growth. May play a role in remodeling of the actin cytoskeleton (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-3019R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-3019R-CY5.5
Lokale Artikelnummer::
BOSSBS-3019R-CY5.5
Beschreibung:
Regulates eIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15208R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15208R-A555
Lokale Artikelnummer::
BOSSBS-15208R-A555
Beschreibung:
C5orf49 is a With 181 million base pairs encoding around 1,000 genes, chromosome 5 is about 6% of human genomic DNA. It is associated with Cockayne syndrome through the ERCC8 gene and familial adenomatous polyposis through the adenomatous polyposis coli (APC) tumor suppressor gene. Treacher Collins syndrome is also chromosome 5 associated and is caused by insertions or deletions within the TCOF1 gene. Deletion of the p arm of chromosome 5 leads to Cri du chat syndrome. Deletion of 5q or chromosome 5 altogether is common in therapy-related acute myelogenous leukemias and myelodysplastic syndrome. The C5orf49 gene product has been provisionally designated C5orf49 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7739R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7739R-CY5
Lokale Artikelnummer::
BOSSBS-7739R-CY5
Beschreibung:
Involved in cytokinesis and septation where it has a role in the localization of F-actin.Tissue specificity: Ubiquitously expressed except in brain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6802R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6802R-CY5
Lokale Artikelnummer::
BOSSBS-6802R-CY5
Beschreibung:
CAB39L
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6981R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6981R-HRP
Lokale Artikelnummer::
BOSSBS-6981R-HRP
Beschreibung:
Mediates the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the endosome and synaptic vesicle lumen, and may thereby affect vesicle trafficking and exocytosis. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9122R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9122R-CY7
Lokale Artikelnummer::
BOSSBS-9122R-CY7
Beschreibung:
F box protein 38 probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It may coactivate KLF7, but does not seem to promote KLF7 ubiquitination. There are three named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-15512R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15512R-FITC
Lokale Artikelnummer::
BOSSBS-15512R-FITC
Beschreibung:
CCL26 is a recently discovered CC chemokine. It binds to the CCR3 receptor and is highly chemotactic for eosinophils and basophils.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0179R-A750)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0179R-A750
Lokale Artikelnummer::
BOSSBS-0179R-A750
Beschreibung:
Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity).
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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