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BIOSS INC
Artikel-Nr:
(BOSSBS-13265R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13265R
Lokale Artikelnummer::
BOSSBS-13265R
Beschreibung:
Anti-GALE Rabbit Polyclonal Antibody
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11347R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11347R-CY5
Lokale Artikelnummer::
BOSSBS-11347R-CY5
Beschreibung:
Postsynaptic scaffolding protein at the parallel fiber-Purkinje cell synapse, where it may serve to link GRID2 with actin cytoskeleton and various signaling molecules.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10397R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10397R-CY5
Lokale Artikelnummer::
BOSSBS-10397R-CY5
Beschreibung:
This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0168R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0168R-CY5
Lokale Artikelnummer::
BOSSBS-0168R-CY5
Beschreibung:
Receptor for persephin. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0257R-CY5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0257R-CY5
Lokale Artikelnummer::
BOSSBS-0257R-CY5
Beschreibung:
Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-10067R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-10067R-A488
Lokale Artikelnummer::
BOSSBS-10067R-A488
Beschreibung:
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4985R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4985R-A647
Lokale Artikelnummer::
BOSSBS-4985R-A647
Beschreibung:
Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc and 14-3-3 proteins. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT/PKB pathway and the Ras-MAPK pathway. The result of activating the MAPK pathway is increased cellular proliferation, whereas activating the PI3K pathway inhibits apoptosis and stimulates protein synthesis. Phosphorylated IRS1 can activate the 85 kDa regulatory subunit of PI3K (PIK3R1), leading to activation of several downstream substrates, including protein AKT/PKB. AKT phosphorylation, in turn, enhances protein synthesis through mTOR activation and triggers the antiapoptotic effects of IGFIR through phosphorylation and inactivation of BAD. In parallel to PI3K-driven signaling, recruitment of Grb2/SOS by phosphorylated IRS1 or Shc leads to recruitment of Ras and activation of the ras-MAPK pathway. In addition to these two main signaling pathways IGF1R signals also through the Janus kinase/signal transducer and activator of transcription pathway (JAK/STAT). Phosphorylation of JAK proteins can lead to phosphorylation/activation of signal transducers and activators of transcription (STAT) proteins. In particular activation of STAT3, may be essential for the transforming activity of IGF1R. The JAK/STAT pathway activates gene transcription and may be responsible for the transforming activity. JNK kinases can also be activated by the IGF1R.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7574R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7574R-A350
Lokale Artikelnummer::
BOSSBS-7574R-A350
Beschreibung:
RRAS
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7111R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7111R-HRP
Lokale Artikelnummer::
BOSSBS-7111R-HRP
Beschreibung:
Receptor for EDA isoform A2, but not for EDA isoform A1. Mediates the activation of the NF-kappa-B and JNK pathways. Activation seems to be mediated by binding to TRAF3 and TRAF6.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6816R-A680)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6816R-A680
Lokale Artikelnummer::
BOSSBS-6816R-A680
Beschreibung:
This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5073R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5073R-HRP
Lokale Artikelnummer::
BOSSBS-5073R-HRP
Beschreibung:
IDI1 is a peroxisomally localized enzyme that catalyzes the interconversion of isopentenyl diphosphate (IPP) to its highly electrophilic isomer, dimethylallyl diphosphate (DMAPP). These are substrates for the reactions that ultimately result in the synthesis of cholesterol. There is reduction in IPP isomerase activity in peroxisomal deficiency diseases such as Zellweger syndrome and neonatal adrenoleukodystrophy.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-4550R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-4550R-A350
Lokale Artikelnummer::
BOSSBS-4550R-A350
Beschreibung:
Pectinesterase
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5147R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5147R-CY7
Lokale Artikelnummer::
BOSSBS-5147R-CY7
Beschreibung:
This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11024R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11024R-A647
Lokale Artikelnummer::
BOSSBS-11024R-A647
Beschreibung:
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5667R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5667R-HRP
Lokale Artikelnummer::
BOSSBS-5667R-HRP
Beschreibung:
Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5982R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5982R-CY3
Lokale Artikelnummer::
BOSSBS-5982R-CY3
Beschreibung:
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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