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BIOSS INC
Artikel-Nr:
(BOSSBS-8376R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8376R-A488
Lokale Artikelnummer::
BOSSBS-8376R-A488
Beschreibung:
RNF160 may function as an E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8356R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8356R-CY5.5
Lokale Artikelnummer::
BOSSBS-8356R-CY5.5
Beschreibung:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of CHIP, TRAF6 and TRIM63/MURF1. Ubiquitinates CHIP-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1469R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1469R-A647
Lokale Artikelnummer::
BOSSBS-1469R-A647
Beschreibung:
Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1564R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1564R-CY7
Lokale Artikelnummer::
BOSSBS-1564R-CY7
Beschreibung:
The Annexins are a family of structurally similar proteins. Annexins bind to phospholipids and may be involved in regulation of membrane transport, membrane channel activity, and interaction of the cell membrane with the extracellular matrix. Annexin A4 (ANXA4) belongs to the annexin family of calcium dependent phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane related events along exocytotic and endocytotic pathways. ANXA4 has 45 to 59% identity with other members of its family and shares a similar size and exon intron organization. Isolated from human placenta, ANXA4 encodes a protein that has possible interactions with ATP, and has in vitro anticoagulant activity and also inhibits phospholipase A2 activity. ANXA4 is almost exclusively expressed in epithelial cells.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0979R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0979R-A647
Lokale Artikelnummer::
BOSSBS-0979R-A647
Beschreibung:
Synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity (By similarity).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9540R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9540R-CY7
Lokale Artikelnummer::
BOSSBS-9540R-CY7
Beschreibung:
Making up nearly 6% of the human genome, chromosome 6 contains around 1,200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf58 gene product has been provisionally designated C6orf58 pending further characterization.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-9669R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-9669R-A350
Lokale Artikelnummer::
BOSSBS-9669R-A350
Beschreibung:
DENND4C is a 1,673 amino acid multi-pass membrane protein. DENND4C contains a dDENN domain, DENN domain, uDENN domain and a PPR (pentatricopeptide) repeat. As a result of alternative splicing, six DENND4C isoforms exist. The gene encoding DENND4C maps to human chromosome 9, which houses over 900 genes and comprises nearly 4% of the human genome. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, and Familial dysautonomia, are both associated with chromosome 9. Notably, chromosome 9 encompasses the largest interferon family gene cluster.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-0282R)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-0282R
Lokale Artikelnummer::
BOSSBS-0282R
Beschreibung:
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-8335R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-8335R-A350
Lokale Artikelnummer::
BOSSBS-8335R-A350
Beschreibung:
Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6391R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6391R-HRP
Lokale Artikelnummer::
BOSSBS-6391R-HRP
Beschreibung:
P15RS is upregulated in cells overexpressing cyclin-dependent kinase inhibitor p15(INK4b) (CDKN2B; MIM 600431) and may have a role in cell cycle regulation
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-6281R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-6281R-CY7
Lokale Artikelnummer::
BOSSBS-6281R-CY7
Beschreibung:
This gene encodes a type II transmembrane serine protease. The encoded protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain. This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer. Alternative splicing results in multiple transcript variants.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7064R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7064R-CY7
Lokale Artikelnummer::
BOSSBS-7064R-CY7
Beschreibung:
Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13692R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13692R-A488
Lokale Artikelnummer::
BOSSBS-13692R-A488
Beschreibung:
MS4A6A is a member of the membrane-spanning 4A gene family and may be involved in signal transduction as a component of a multimeric receptor complex. There are three named isoforms.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1328R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1328R-A350
Lokale Artikelnummer::
BOSSBS-1328R-A350
Beschreibung:
Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12096R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12096R-A350
Lokale Artikelnummer::
BOSSBS-12096R-A350
Beschreibung:
Peroxisomes are single-membrane bound organelles present in virtually all eukaryotic cells. They are involved in numerous catabolic and anabolic pathways, including beta-oxidation of very long chain fatty acids, metabolism of hydrogen peroxide, plasmalogen biosynthesis and bile acid synthesis. The Peroxin gene family, which includes more than 20 members, is required for peroxisome biogenesis. Peroxin 5R, also known as PEX5-related protein or Peroxisome biogenesis factor 5-like, is a 626 amino acid protein that is mainly expressed in brain, with some expression in testis and pancreas. Peroxin 5R contains five TPR repeats, which enable protein-protein interactions and assembly of large multiprotein complexes. There are three isoforms of Peroxin 5R that are produced as a result of alternative splicing events. These isoforms bind C-terminal peroxisome-targeting signals in a similar manner to Peroxin-5. Peroxin 5R interacts with Rab 8b, possibly playing a role in vesicular trafficking and neurotransmitter release.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13537R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13537R-CY7
Lokale Artikelnummer::
BOSSBS-13537R-CY7
Beschreibung:
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin-sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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