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BIOSS INC
Artikel-Nr:
(BOSSBS-15237R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-15237R-A488
Lokale Artikelnummer::
BOSSBS-15237R-A488
Beschreibung:
Making up nearly 6% of the human genome, chromosome 6 contains around 1200 genes within 170 million base pairs of sequence. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer suggesting the presence of a cancer susceptibility locus. Porphyria cutanea tarda is associated with chromosome 6 through the HFE gene which, when mutated, predisposes an individual to developing this porphyria. Notably, the PARK2 gene, which is associated with Parkinson's disease, and the genes encoding the major histocompatiblity complex proteins, which are key molecular components of the immune system and determine predisposition to rheumatic diseases, are also located on chromosome 6. Stickler syndrome, 21-hydroxylase deficiency and maple syrup urine disease are also associated with genes on chromosome 6. A bipolar disorder susceptibility locus has been identified on the q arm of chromosome 6. The C6orf203 gene product has been provisionally designated C6orf203 pending further characterisation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-1296R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-1296R-CY7
Lokale Artikelnummer::
BOSSBS-1296R-CY7
Beschreibung:
Beta-defensin 2 (BD-2) also known as skin-antimicrobial peptide 1 (SAP1) is a peptide that is encoded by the DEFB4 (defensin, beta 4) gene. Defensins form a family of microbicidal and cytotoxic peptides made by neutrophils. Members of the defensin family are highly similar in protein sequence. Beta-defensin 2 is an antibiotic peptide which is locally regulated by inflammation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11014R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11014R-HRP
Lokale Artikelnummer::
BOSSBS-11014R-HRP
Beschreibung:
ILVBL is a 632 amino acid single-pass membrane protein that belongs to the TPP enzyme family. Expressed in the majority of tissues, ILVBL has the highest level of expression in heart, pancreas and placenta. ILVBL is highly homologous to several bacterial enzymes, including the B isozyme of the large catalytic subunit of E. coli acetohydroxy-acid synthase (AHAS) and the oxalyl-coA decarboxylase of O. formigenes, that utilize thiamine pyrophosphate as a cofactor. ILVBL binds one magnesium ion and one thiamine pyrophosphate per subunit, and may catalyze the initial step in branched-chain amino acid biosynthesis. The gene encoding ILVBL maps to human chromosome 19p13.12 and mouse chromosome 10 C1.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-12250R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-12250R-HRP
Lokale Artikelnummer::
BOSSBS-12250R-HRP
Beschreibung:
Sorting nexin (SNX) proteins are members of a large family of hydrophilic PX (phospholipid-binding motif) domain-containing proteins that interact with a variety of receptor types. SNXs are widely expressed, although the tissue distribution of each SNX mRNA varies. The ability of SNXs to bind specific phospholipids, as well as their tendency to form protein-protein complexes, suggests a role for these proteins in cellular membrane trafficking and protein sorting. SNXs may also function specifically in pro-degradative sorting, internalization, endosomal recycling or simply in endosomal sorting. SNXs partially associate with cellular membranes, despite their hydrophilic nature. SNX7 is unique in that it does not have a coiled coil region like some of the SNX family members. Mutations in the SNX7 gene have not been shown to cause any diseases.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13320R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13320R-FITC
Lokale Artikelnummer::
BOSSBS-13320R-FITC
Beschreibung:
The gamma-Tubulin complex is composed of gamma Tubulin and the gamma-Tubulin complex-associated proteins GCP2, GCP3, GCP4, GCP5 and GCP6, all of which are essential components of microtubule organizing centers. gamma-Tubulin complex components are localized to both the centrosome, where they are involved in microtubule nucleation, and to the cytoplasm, where they exist as soluble complexes that can be recruited to the centrosome as needed. Although the GCP proteins are related, they have distinct roles which contribute to the proper function of the gamma-Tubulin complex. GCP4 (gamma-tubulin complex component 4), also known as TUBGCP4, is a ubiquitously expressed 667 amino acid member of the gamma-Tubulin complex that localizes to the metaphase spindle during mitosis. In response to proteosome inhibition, GCP4 exhibits increased accumulation at the pericentiolar material where it participates in microtubule organization and nucleation.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2642R-FITC)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2642R-FITC
Lokale Artikelnummer::
BOSSBS-2642R-FITC
Beschreibung:
Receptor on natural killer (NK) cells for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7). Inhibits the activity of NK cells thus preventing cell lysis.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2002R-A555)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2002R-A555
Lokale Artikelnummer::
BOSSBS-2002R-A555
Beschreibung:
Influenza A virus is a major public health threat. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. During 1997, an H5N1 avian influenza virus was determined to be the cause of death in 6 of 18 infected patients in Hong Kong. There was some evidence of human to human spread of this virus, but it is thought that the transmission efficiency was fairly low. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species jumping ability.Influenza A Virus [A/California/04/2009(H1N1)]
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13383R-CY3)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13383R-CY3
Lokale Artikelnummer::
BOSSBS-13383R-CY3
Beschreibung:
Glucoamylase is an important industrial enzyme used in saccharification steps in both starch enzymatic conversion and in alcohol production. The catalytic domain degrades oligosaccharides from the non reducing end, releasing glucose, and the starch domain binds the enzyme to raw starch and to the cell wall.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-2641R-CY7)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-2641R-CY7
Lokale Artikelnummer::
BOSSBS-2641R-CY7
Beschreibung:
Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5506R-CY5.5)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5506R-CY5.5
Lokale Artikelnummer::
BOSSBS-5506R-CY5.5
Beschreibung:
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. MAPK11 is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5324R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5324R-A488
Lokale Artikelnummer::
BOSSBS-5324R-A488
Beschreibung:
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro).
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5342R-A350)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5342R-A350
Lokale Artikelnummer::
BOSSBS-5342R-A350
Beschreibung:
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008].
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-5959R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-5959R-A647
Lokale Artikelnummer::
BOSSBS-5959R-A647
Beschreibung:
Part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. Four known isoforms exist.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-7115R-HRP)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-7115R-HRP
Lokale Artikelnummer::
BOSSBS-7115R-HRP
Beschreibung:
MLC1 is a 377 amino acid multi-pass membrane protein that may serve as a non-selective neuronal cation channel in brain. Mutant MLC1 proteins that show impaired folding have been corrected in vitro with the addition of a Ca(2+)-ATPase inhibitor, curcumin. Mutations in the gene encoding MLC1 is the cause of megalencephalic leukoencephalopathy with subcortical cysts, also known as van der Knaap disease, a rare syndrome characterized early in life by progressive brain destruction causing mental retardation and incoordination. Single nucleotide polymorphisms within the MLC1 gene may be associated with periodic catatonia, but there seems to be conflicting evidence on whether or not the gene is implicated in general schizophrenia.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-11766R-A488)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-11766R-A488
Lokale Artikelnummer::
BOSSBS-11766R-A488
Beschreibung:
In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that are required for transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH; and sequence-specific factors that regulate gene expression. The basal transcription factors and Pol II form a specific multiprotein complex near the transcription start site by interacting with core promotor elements such as the TATA box generally located 25-30 base pairs upstream of the transcription start site. Binding of TFIID to the TATA element initiates assembly of the other factors into a pre-initiation complex. The TATA-binding subunit of TFIID (designated TFIIDt or TBP) from higher eukaryotes contains a highly conserved 180 amino acid C-terminal domain.
VE:
1 * 100 µl
Artikel-Nr:
(BOSSBS-13611R-A647)
Lieferant:
Bioss
Hersteller-Artikelnummer::
BS-13611R-A647
Lokale Artikelnummer::
BOSSBS-13611R-A647
Beschreibung:
Sox-30 encodes a member of the Sox (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. Sox-30 is expressed in testis and may act as a transcriptional regulator after forming a protein complex with other proteins. Sox-30 may be involved in the differentiation of developing male germ cells. Two transcript variants encoding distinct isoforms have been identified for the human Sox-30 gene. Sox family transcription factors influence cell differentiation, development and sex determination. Sox-30 contains a unique DNA binding domain, known as the high mobility group (HMG) box, that is related to that of the testis determining gene, SRY. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. Several Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development.
VE:
1 * 100 µl
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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