Sie suchten nach: BIOSENSIS PTY

Lieferant: Biosensis

Beschreibung: Das Fluoro-Jade C Ready-to-Dilute(RTD™)-Färbekit bietet eine Zusammenstellung aus Fluoro-Jade C, DAPI, Natriumhydroxid und Kaliumpermanganat in flüssiger Form.

Sicherheitsdatenblätter

Artikel-Nr: (BSENM-1719-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: M-1719-100

Lokale Artikelnummer:: BSENM-1719-100

Beschreibung: TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: Cell membrane; single-pass type I membrane protein. Endocytosed to the endosomes upon treatment of cells with NGF. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. Both isoforms have similar biological properties. TISSUE SPECIFICITY: Isoform TrkA-II is primarily expressed in neuronal cells. Isoform TrkA-I is found in non-neuronal tissues. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutalating behaviour, mental retardation and cancer (Reference: www.uniprot.com).

VE: 1 * 100 µG

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Artikel-Nr: (BSENM-1797-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: M-1797-100

Lokale Artikelnummer:: BSENM-1797-100

Beschreibung: Buffers cytosolic calcium. May stimulate a membrane Ca2+-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. Ref: uniprot.org

VE: 1 * 100 µG

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Artikel-Nr: (BSENC-1807-50)

Lieferant: Biosensis

Hersteller-Artikelnummer:: C-1807-50

Lokale Artikelnummer:: BSENC-1807-50

Beschreibung: Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable). Ref: uniprot.org

VE: 1 * 50 µl

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Artikel-Nr: (BSENBEK-2237-1P)

Lieferant: Biosensis

Hersteller-Artikelnummer:: BEK-2237-1P

Lokale Artikelnummer:: BSENBEK-2237-1P

Beschreibung: The Biosensis proBDNF (Brain-derived neurotrophic factor, BDNF, Abrineurin) RapidTM enzyme-linked immunosorbent assay (ELISA) Kit is a sandwich ELISA that allows the specific, fast and reliable quantification of proBDNF in less than 4 hours in cell culture supernatants, human serum and EDTA-plasma only if used as directed. Please refer to the kit protocol for specific use instructions for each substrate application, in particular human blood samples.

VE: 1 * 1 KIT

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Artikel-Nr: (BSENM-1249-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: M-1249-100

Lokale Artikelnummer:: BSENM-1249-100

Beschreibung: X63 is a control mouse IgG antibody with no known reactivity. The antibody has been used successfully a negative control in westerns, all forms of IHC, IP and FACS

VE: 1 * 100 µG

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Artikel-Nr: (BSENR-1588-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: R-1588-100

Lokale Artikelnummer:: BSENR-1588-100

Beschreibung: Glutathione peroxidase 1 has a role in detoxification of hydrogen peroxide and is one of the most important antioxidant enzymes in humans. It exists as a homotetramer which localises to the cytoplasm. It belongs to the glutathione peroxidase family. Glutathione peroxidase 1 is one of few proteins in higher vertebrates to contain selenocysteine, which occurs at the active site of glutathione peroxidase and is coded by UGA, that normally functions as a translation termination codon. This protein has a polyalanine sequence polymorphism in the N-terminal region, which includes three alleles with five, six or seven alanine repeats. The allele with five alanine repeats is significantly associated with breast cancer risk. At least two alternatively spliced isoforms have been identified.

VE: 1 * 100 µG

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Artikel-Nr: (BSENS-053-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: S-053-100

Lokale Artikelnummer:: BSENS-053-100

Beschreibung: NT3 is a member of the neurotrophin family, that controls survival and differentiation of visceral and proprioceptive sensory neurons. NT3 is closely related to both NGF and BDNF. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT3-deficient mice generated by gene targeting display sevvere movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family.

VE: 1 * 100 µl

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Artikel-Nr: (BSENR-158-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: R-158-100

Lokale Artikelnummer:: BSENR-158-100

Beschreibung: ATG16 L1 plays an essential role in autophagy. It is a homooligomer ant interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa). APG16 L1 localises to the cytoplasm, in particularly to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. There are 5 named isoforms produced by alternative splicing. Genetic variation within ATG16 L1 are associated with susceptibility to inflammatory bowel disease type 1.

VE: 1 * 100 µl

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Artikel-Nr: (BSENR-175-20)

Lieferant: Biosensis

Hersteller-Artikelnummer:: R-175-20

Lokale Artikelnummer:: BSENR-175-20

Beschreibung: NT3 is a member of the neurotrophin family, that controls survival and differentiation of visceral and proprioceptive sensory neurons. NT3 is closely related to both NGF and BDNF. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NT3-deficient mice generated by gene targeting display sevvere movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. SUBCELLULAR LOCATION: Secreted protein. TISSUE SPECIFICITY: Brain and peripheral tissues. SIMILARITY: Belongs to the NGF-beta family.

VE: 1 * 20 µG

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Artikel-Nr: (BSENR-1495-50)

Lieferant: Biosensis

Hersteller-Artikelnummer:: R-1495-50

Lokale Artikelnummer:: BSENR-1495-50

Beschreibung: Endomorphins 1 and 2 are endogenous opioid peptides which have the highest affinity for the mu-opioid receptors. Located in various parts of the brain and interacts with mu-opioid receptors and produces analgesia.

VE: 1 * 50 µG

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Artikel-Nr: (BSENR-118-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: R-118-100

Lokale Artikelnummer:: BSENR-118-100

Beschreibung: Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. FUNCTION: Plays an important role in the physiology of adrenergic neurons. CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. COFACTOR: Fe(2+) ion. ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity. PATHWAY: Catecholamine biosynthesis; first step. SUBUNIT: Homotetramer. PTM: In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation. SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality.

VE: 1 * 100 µl

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Artikel-Nr: (BSENR-106-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: R-106-100

Lokale Artikelnummer:: BSENR-106-100

Beschreibung: The neural adhesion molecule Contactin-6, also known as NB-3, is a contactin/F3 subgroup member of immunoglobulin superfamily. It is expressed exclusively in the nervous system and mainly upregulated at the early postnatal stage during mouse brain development. Employing Northern blot analysis Kamei et al found that amongst different regions of the adult human nervous system cerebellum expressed highest level of NB-3 mRNA. The expression of NB-3 in the cerebellum increases until adulthood. In contrast, the expression in the cerebrum declines to a low level after postnatal day 7. NB-3 like other neural recognition molecules plays a vitally important role in axonal guidance during development, plasticity, and maintenance of synaptic connections in the adult brain. Cui et al recently showed that NB-3 acts as a novel Notch ligand to participate in oligodendrocyte generation. Furthermore, NB-3 triggers nuclear translocation of the Notch intracellular domain and promotes oligodendrogliogenesis from progenitor cells and differentiation of oligodendrocyte precursor cells via Deltex1. In primary oligodendrocytes, NB-3 increases myelin-associated glycoprotein transcripts. Hence, the NB-3/Notch signaling pathway may be worthwhile a closer examination for its potential for the treatment of demyelinating diseases. Human NB-3 shares with rat NB-3 86% identity in nucleotide sequences and 90% identity in amino acid sequences. FUNCTION: Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination. SUBCELLULAR LOCATION: Cell membrane; lipid-anchor; GPI-anchor. ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. TISSUE SPECIFICITY: Expressed in brain. In brain, it is preferentially expressed in the accessory olfactory bulb, layers II/III and V of the cerebral cortex, piriform cortex, anterior thalamic nuclei, locus coeruleus of the pons and mesencephalic trigeminal nucleus and in Purkinje cells of the cerebellum.

VE: 1 * 100 µl

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Artikel-Nr: (BSENGP-032-50)

Lieferant: Biosensis

Hersteller-Artikelnummer:: GP-032-50

Lokale Artikelnummer:: BSENGP-032-50

Beschreibung: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR) and upon binding to the receptor it induces the release of growth hormone from the pituitary. This ligand has an appetite-stimulating effect and is involved in growth regulation.

VE: 1 * 50 µl

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Artikel-Nr: (BSENM-1301-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: M-1301-100

Lokale Artikelnummer:: BSENM-1301-100

Beschreibung: The D-tag system utilises a short hydrophilic peptide (DYKDDDDK) that is fused to either the N- or C-terminus of the protein of interest. It can be used in conjunction with other tags such as the 6X His tag.

VE: 1 * 100 µG

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Artikel-Nr: (BSENM-1309-100)

Lieferant: Biosensis

Hersteller-Artikelnummer:: M-1309-100

Lokale Artikelnummer:: BSENM-1309-100

Beschreibung: The Human influenza hemagglutin (HA) tag corresponds to a region (98-106 amino acids) from the HA molecule.

VE: 1 * 100 µG

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