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28 362 results were found
PROSCI
Artikel-Nr:
(PRSI29-055)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
29-055
Lokale Artikelnummer::
PRSI29-055
Beschreibung:
DMAP1 is a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.This gene encodes a subunit of several, distinct complexes involved in the repression or activation of transcription. The encoded protein can independently repress transcription and is targeted to replication foci throughout S phase by interacting directly with the N-terminus of DNA methyltransferase 1. During late S phase, histone deacetylase 2 is added to this complex, providing a means to deacetylate histones in transcriptionally inactive heterochromatin following replication. The encoded protein is also a component of the nucleosome acetyltransferase of H4 complex and interacts with the transcriptional corepressor tumor susceptibility gene 101 and the pro-apoptotic death-associated protein 6, among others. Alternatively spliced transcript variants encoding the same protein have been described.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4979)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4979
Lokale Artikelnummer::
PRSI4979
Beschreibung:
RNAse H2A Antibody: Ribonucleases (RNAses) H are enzymes that hydrolyze the RNA strands of RNA/DNA hybrids. The major role of these enzymes is to remove the RNA strand from the RNA/DNA hybrids that form during DNA replication and repair. RNAse H2 is made up of three subunits; all three are required for RNAse activity. Recent evidence has demonstrated that mutations in RNAse H2A or any of the other subunits result in Aicardi-Goutieres syndrome (AGS), a neurological disorder with similar symptoms to viral brain infections including high levels of IFN-alpha in the cerebral spinal fluid. Similar conditions are observed with mutations in TREX1, a single-stranded DNA exonuclease, suggesting that RNAse H2 and TREX1 may have similar roles, and that mutations in any of these genes lead to an accumulation of intracellular nucleic acids, triggering an inflammatory response through activation of the innate immune system.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4989)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4989
Lokale Artikelnummer::
PRSI4989
Beschreibung:
KLRA1 Antibody: KLRA1 (also known and Ly49L) is a member of the LY49 family of receptors Natural killer (NK) cells that bind to major histocompatibility complex (MHC) class 1. These proteins are classified as either activating or inhibitory receptors based on whether they possess an immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic region (for inhibitory receptors), or an immunoreceptor tyrosine-based activation motif (ITAM) that transmits activating signals resulting in phosphorylation of several substrates. KLRA1 is thought to be an activating receptor, inducing DAP12 phosphorylation in response to antibody-mediated cross-linking of KLRA1 on NK cells. At least three isoforms of KLRA1 are known to exist.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI5383P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5383P
Lokale Artikelnummer::
PRSI5383P
Beschreibung:
JMJD6 peptide is used for blocking the activity of JMJD6 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI79-198)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-198
Lokale Artikelnummer::
PRSI79-198
Beschreibung:
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI79-202)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-202
Lokale Artikelnummer::
PRSI79-202
Beschreibung:
Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI79-227)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-227
Lokale Artikelnummer::
PRSI79-227
Beschreibung:
Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI79-200)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-200
Lokale Artikelnummer::
PRSI79-200
Beschreibung:
NF-κ-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-κ-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-κ-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-κ-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-κ-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-κ-B complex which translocates to the nucleus. NF-κ-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-κ-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-κ-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA-binding site which could contribute directly to DNA binding in the NF-κ-B complex
VE:
1 * 100 µG
Artikel-Nr:
(PRSI79-208)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-208
Lokale Artikelnummer::
PRSI79-208
Beschreibung:
Receptor for EGF, but also for other members of the EGF family, as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. Is involved in the control of cell growth and differentiation. Phosphorylates MUC1 in breast cancer cells and increases the interaction of MUC1 with SRC and CTNNB1/beta-catenin.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI79-216)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-216
Lokale Artikelnummer::
PRSI79-216
Beschreibung:
Involved in stress resistance and actin organization.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI79-195)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
79-195
Lokale Artikelnummer::
PRSI79-195
Beschreibung:
Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates ERK1 and ERK2 MAP kinases.
VE:
1 * 100 µG
Artikel-Nr:
(PRSI51-267)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
51-267
Lokale Artikelnummer::
PRSI51-267
Beschreibung:
Anti-CXCR2 Rabbit Polyclonal Antibody
VE:
1 * 50 µG
Artikel-Nr:
(PRSI46-239)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
46-239
Lokale Artikelnummer::
PRSI46-239
Beschreibung:
Anti-PSME2 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI46-414)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
46-414
Lokale Artikelnummer::
PRSI46-414
Beschreibung:
Anti-SORBS1 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI46-424)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
46-424
Lokale Artikelnummer::
PRSI46-424
Beschreibung:
Anti-SOX8 Goat Polyclonal Antibody
VE:
1 * 100 µG
Artikel-Nr:
(PRSI46-437)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
46-437
Lokale Artikelnummer::
PRSI46-437
Beschreibung:
Anti-STAG3 Goat Polyclonal Antibody
VE:
1 * 100 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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