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TONBO BIOSCIENCE
Artikel-Nr:
(65-4732-U100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
65-4732-U100
Lokale Artikelnummer::
TNBO65-4732-U100
Beschreibung:
The MPC-11 immunoglobulin is useful as an isotype-matched control. The MPC-11 immunolglobulin has an unknown binding specificity and is used as an isotype control for mouse IgG2b antibodies.
VE:
1 * 100 µG
Lieferant:
Tonbo Biosciences
Beschreibung:
The HI30 antibody reacts with human CD45, one of the most abundant hematopoietic markers and one that is expressed on all leukocytes (the Leukocyte Common Antigen, LCA). CD45 is a protein tyrosine phosphatase existing in several isoforms, each being generated and expressed in cell-specific patterns. With its broad cell distribution, CD45 is critical for many leukocyte functions, regulating signal transduction and cell activation associated with the T cell receptor, B cell receptor, and IL-2 receptor. Other forms of CD45, with restricted cellular expression, include CD45R (B220), CD45RA, CD45RB, CD45RO and others.
Lieferant:
Tonbo Biosciences
Beschreibung:
The UCHT1 antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor – CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognise antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.
Artikel-Nr:
(25-4321-U100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
25-4321-U100
Lokale Artikelnummer::
TNBO25-4321-U100
Beschreibung:
The A3 immunoglobulin is useful as an isotype-matched control. The 2A3 immunolglobulin binds to TNP (trinitrophenol), a hapten not expressed on mouse or human cells. It is used as an isotype control for rat IgG2a antibodies.
VE:
1 * 100 µG
Artikel-Nr:
(40-1276-U100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
40-1276-U100
Lokale Artikelnummer::
TNBO40-1276-U100
Beschreibung:
The 1A8 antibody binds to mouse Ly-6G, commonly known as Gr-1, a member of the Ly-6 superfamily of GPI-anchored cell surface proteins with roles in cell signaling and cell adhesion. Gr-1 is differentially expressed during development and maturation of cells in the myeloid lineage and is expression at varying stages and levels on monocytes, macrophages, granulocytes, and peripheral neutrophils.
VE:
1 * 100 µG
Artikel-Nr:
(35-8058-U500)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
35-8058-U500
Lokale Artikelnummer::
TNBO35-8058-U500
Beschreibung:
Goat anti-Rabbit IgG (H&L), F(ab')2 Fragment - Affinity Pure, FITC Conjugate
VE:
1 * 0,5 mg
Artikel-Nr:
(75-4301-U100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
75-4301-U100
Lokale Artikelnummer::
TNBO75-4301-U100
Beschreibung:
The HRPN immunoglobulin is useful as an isotype-matched control. The HRPN immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG1 antibodies.
VE:
1 * 100 µG
Artikel-Nr:
(70-8076-M002)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
70-8076-M002
Lokale Artikelnummer::
TNBO70-8076-M002
Beschreibung:
Rabbit anti-Mouse IgG (H&L) - Affinity Pure
VE:
1 * 2 mg
Artikel-Nr:
(50-8033-U100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
50-8033-U100
Lokale Artikelnummer::
TNBO50-8033-U100
Beschreibung:
Goat anti-mouse IgG (H+L), secondary antibody, SureLight® R-Phycoerythrin, 100ug
VE:
1 * 100 µG
Artikel-Nr:
(35-8070-M002)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
35-8070-M002
Lokale Artikelnummer::
TNBO35-8070-M002
Beschreibung:
Goat anti-Rabbit IgG (H&L) - Affinity Pure, FITC Conjugate, min x w/bovine, human, or mouse IgG
VE:
1 * 2 mg
Artikel-Nr:
(70-0088-U100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
70-0088-U100
Lokale Artikelnummer::
TNBO70-0088-U100
Beschreibung:
The RPA-T8 antibody is specific for the 32-34 kDa alpha chain of human CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor for antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.
VE:
1 * 100 µG
Artikel-Nr:
(92-7770-T100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
92-7770-T100
Lokale Artikelnummer::
TNBO92-7770-T100
Beschreibung:
The FITC Mouse Lineage Cocktail contains a combination of pre-diluted antibodies that identify lineage committed cells by flow cytometry and facilitate their exclusion from hematopoietic progenitor cells in mouse bone marrow. The antibodies in the cocktail react with cells from major hematopoietic lineages including T, B and NK cells, monocytes/macrophages, granulocytes and erythrocytes. The Lineage Cocktail contains the following FITC conjugated antibodies: anti-mouse CD3 (17A2), anti-mouse CD11b (M1/70), anti-mouse CD45/B220 (RA3-6B2), anti-mouse Ly-6G (Gr-1) (RB6-8C5) and anti-mouse TER-119 (TER-119). An Isotype Control Cocktail consisting of FITC conjugated isotype-matched control antibodies (Rat IgG2a, kappa; Rat IgG2b, kappa) is also provided in a separate vial.
VE:
1 * 100 Tests
Artikel-Nr:
(70-4031-U100)
Lieferant:
Tonbo Biosciences
Hersteller-Artikelnummer::
70-4031-U100
Lokale Artikelnummer::
TNBO70-4031-U100
Beschreibung:
The LTF-2 immunoglobulin is useful as an isotype-matched control. The LTF-2 immunolglobulin has an unknown binding specificity and is used as an isotype control for rat IgG2b antibodies.
VE:
1 * 100 µG
Lieferant:
Tonbo Biosciences
Beschreibung:
The 3G3 antibody reacts with mouse Foxp3, a 50-55 kDa transcription factor which is a central regulator of T cell activity and is critical for the development and function of regulatory T cells (Tregs). Foxp3 is expressed at constitutively high levels in Treg cells, which are further identified as being CD4+ CD25+. In resting conventional T cells (CD4+ CD25-) Foxp3 expression is restricted, and upon TCR activation is expressed only transiently and in a small proportion of cells. However, the growth factor TGF-beta has been shown to induce expression of Foxp3 in naïve T cells, driving their development into Foxp3+ Tregs, which are called “induced” or “adaptive” Tregs. These cells are phenotypically similar to so-called “natural” Tregs (CD4+ CD25high Foxp3+) which originate in the thymus and comprise the majority of Treg cells. Tregs are critical for maintaining peripheral tolerance and are implicated in the development of autoimmunity.
Lieferant:
Tonbo Biosciences
Beschreibung:
The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.
Lieferant:
Tonbo Biosciences
Beschreibung:
The 1D3 antibody reacts with mouse CD19, a 95 kDa glycoprotein which acts as a co-receptor, along with CD21 and CD81, in support of the functional B cell receptor (BCR). This complex provides antigen-specific recognition and subsequent activation of B cells to proliferate and differentiate into antibody-secreting cells (plasma cells) or memory B cells, which are crucial for secondary antigen encounter. CD19 is a lineage-differentiation marker, as its expression is detectable at the earliest B cell stages, through development, and is finally lost upon transition to mature plasma cells.
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Dieses Produkt kann nur an eine Lieferadresse versandt werden die über die entsprechende Lizenzen verfügt. Für weitere Hilfe bitte kontaktieren Sie Ihr VWR Vertriebszentrum.
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