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Proteine und Peptide
Artikel-Nr:
(PRSI5197P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5197P
Lokale Artikelnummer::
PRSI5197P
Beschreibung:
MACC1 peptide is used for blocking the activity of MACC1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-030)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-030
Lokale Artikelnummer::
PRSI96-030
Beschreibung:
Anexin A5 is a phospholipid binding protein, which binds with high affinity and selectivity to PS in the presence of calcium. PS is predominantly located in membrane leaflets, which face the cytosol. However, recent findings show that each cell type has the molecular machinery to expose PS at its cell surface. This machinery is activated during the execution of apoptosis. Once PS is exposed at the cell surface it exhibits procoagulant and proinflammatory activities. Anexin A5 will bind to the PS-exposing apoptotic cell and can inhibit the procoagulant and proinflammatory activities of the dying cell. Anexin A5 has also been identified as an anticoagulant protein in the blood coagulation cascade, by acting as an inhibitor of prothrombin activation. The presence of antibodies to Anexin A5 is associated with systemic lupus erythematosus (SLE), recurrent spontaneous abortions and systemic sclerosis (SSc).
VE:
1 * 100 µG
Artikel-Nr:
(PRSI92-427)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-427
Lokale Artikelnummer::
PRSI92-427
Beschreibung:
Interleukin-12 subunit beta (IL-12B) belongs to the type I cytokine receptor family. It contains 1 fibronectin type-III domain and 1 Ig-like C2-type domain. IL-12B is a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. IL-12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor encoded by IL12B and a 35 kD subunit encoded by IL12A. IL12 is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. It has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Monokine induced by gamma interferon (MIG or CXCL9) is a T cell chemoattractant during neuroinflammatory events. MIG production is stimulated by interferon gamma (IFNɣ) and signals through the chemokine receptor CXCR3.
Artikel-Nr:
(PRSI91-081)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-081
Lokale Artikelnummer::
PRSI91-081
Beschreibung:
Ciliary Neurotrophic Factor (CNTF) is a potent survival factor for neurons and oligodendrocytes. CNTF has also been shown to prevent the degeneration of motor axons after axotomy. CNTF is highly conserved across species and exhibits cross-species activities. Human and rat CNTF share approximately 83% homology in their protein sequence. CNTF is structurally related to IL6, IL11, LIF and OSM. All of these four helix bundle cytokines share gp130 as a signal transducing subunit in their receptor complexes. CNTF, like FGF acidic, FGF basic, and PD-ECGF (platelet-derived endothelial cell growth factor), does not possess a signal sequence that would allow secretion of the factor by classical secretion pathways. The mechanism underlying the release of CNTF is unknown.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI92-570)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-570
Lokale Artikelnummer::
PRSI92-570
Beschreibung:
Ectodysplasin A receptor (EDAR) is a type I transmembrane protein of the TNF- alpha receptor superfamily which plays a key role in ectodermal differentiation. EDAR was encoded by the mouse down less gene and defective in human dominant and recessive forms of autosomal hypo hidrotic ectodermal dysplasia (EDA) syndrome. The extracellular domain of EDAR contains 14 cysteine residues, six of which approximate the TNFRSF cysteine-rich region, the cytoplasmic domain contains a region with homology to the death domains found in other TNFRSF members. EDAR has been suggested to be an early and important promoter of placode development in all ectodermal organs, such as uch as hair follicles, teeth and sweat glands. EDA-A1, the A1 isoform of EDA, is the EDAR ligand. EDA and EDA are implicated in appendage development by the cloning of a gene underlying hypo hidrotic ectodermal dysplasia (HED) in mouse and human. HED is Characterised by agenesis or malformation of ectoderm-derived appendages, such as teeth, sweat glands and hair follicles, while the skin itself develops normally.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI3215P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
3215P
Lokale Artikelnummer::
PRSI3215P
Beschreibung:
ACE2 peptide is used for blocking the activity of ACE2 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-032)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-032
Lokale Artikelnummer::
PRSI90-032
Beschreibung:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI1131P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
1131P
Lokale Artikelnummer::
PRSI1131P
Beschreibung:
TACE peptide is used for blocking the activity of TACE antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-086)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-086
Lokale Artikelnummer::
PRSI96-086
Beschreibung:
Tumor necrosis factor receptor superfamily member 5 (TNFRSF5) is also known as CD40, is a member of the TNF receptor superfamily. The expression of CD40 is diverse. TNFRSF5 has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is the receptor for TNFSF5/CD40LG. Defects in CD40 are the cause of immunodeficiency with hyper-IgM type 3 (HIGM3).
VE:
1 * 200 µG
Artikel-Nr:
(PRSI5065P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5065P
Lokale Artikelnummer::
PRSI5065P
Beschreibung:
LRFN1 peptide is used for blocking the activity of LRFN1 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6499P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6499P
Lokale Artikelnummer::
PRSI6499P
Beschreibung:
UPK1B peptide is used for blocking the activity of UPK1B antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-039)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-039
Lokale Artikelnummer::
PRSI91-039
Beschreibung:
FGF acidic, also known as ECGF, FGF-1and HBGF-1, is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. It is a mitogenic peptide that is produced by multiple cell types and stimulates the proliferation of cells of mesodermal, ectodermal, and endodermal origin. Its association with heparan sulfate is a prerequisite for activation of FGF receptors. Internalized FGF acidic migrates to the nucleus where it is phosphorylated by nuclear PKC delta, exported to the cytosol, dephosphorylated, and degraded. Intracellular FGF acidic inhibits p53 activity and proapoptotic signaling.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5571P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5571P
Lokale Artikelnummer::
PRSI5571P
Beschreibung:
REEP2 peptide is used for blocking the activity of REEP2 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6759P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6759P
Lokale Artikelnummer::
PRSI6759P
Beschreibung:
TSHZ3 peptide is used for blocking the activity of TSHZ3 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-485)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-485
Lokale Artikelnummer::
PRSI91-485
Beschreibung:
Serpin A5 is a member of the human Serpin superfamily consists of at least 35 members. It is synthesized in the liver and has been detected in saliva, cerebral spinal fluid, amniotic fluid, tears and semen. As a potent inhibitor of the protein C anticoagulant pathway at the levels of both zymogen activation and enzyme inhibition, Serpin A5 additionally inhibits a variety of serine protease including thrombin, factor Xa, several kallekreins and acrosin. It plays a critical role in the processes of blood of blood coagulation and fertilization. Serpin A5 also inhibits urinary plasminogen activator (uPA), a mediator of tumor cell invasion, and regulates tumor growth and metastasis by inhibiting angiogenesis. Furthermore, recent studies have identified PCI as a potent and direct inhibitor of activated HGFA (hepatocyte growth factor activator), suggesting a novel function in the regulation of tissue repair and regeneration. Similar to Serpins C1 and D1, the thrombin inhibitory activity of serpinA5 is enhanced by heparin.
VE:
1 * 50 µG
Preis auf Anfrage
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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