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Proteine und Peptide
Artikel-Nr:
(PRSI91-749)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-749
Lokale Artikelnummer::
PRSI91-749
Beschreibung:
Insulin-Like Growth Factor-Binding Protein 5 (IGFBP-5) is a secreted protein that belongs to the insulin-like growth factor (IGF) binding proteins superfamily. Members of this family prolong the half-life of the IGFs. They have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGFBP-5 contains one IGFBP N-terminal domain and one thyroglobulin type-1 domain. IGFBP-5 is expressed by fibroblasts, myoblasts and Osteosarcoma. It is also present at lower levels in liver, kidney, and brain.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5617P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5617P
Lokale Artikelnummer::
PRSI5617P
Beschreibung:
MINA peptide is used for blocking the activity of MINA antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-392)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-392
Lokale Artikelnummer::
PRSI90-392
Beschreibung:
CD28 and CTLA-4 together with their ligands, CD80 (B7-1) and CD86 (B7-2), constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. Both CD28 and CTLA-4 are composed of a single Ig V-like extracellular domain, a transmembrane domain and an intracellular domain. CD28 and CTLA-4 are both expressed on the cell surface as disulfide-linked homodimers or as monomers. The genes encoding these two molecules are closely linked on human chromosome 2 and mouse chromosome 1. Mouse CD28 is expressed constitutively on virtually 100% of mouse T cells and on developing thymocytes. Cell surface expression of mouse CD28 is downregulated upon ligation of CD28 in the presence of PMA or PHA. In contrast, CTLA-4 is not expressed constitutively but is upregulated rapidly following T cell activation and CD28 ligation. Cell surface expression of mouse CTLA-4 peaks approx.y 48 hours after activation. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20-100 fold higher affinity than CD28. CD28/B7 interaction has been shown to prevent apoptosis of activated T cells via the upregulation of bcl-XL. CD28 ligation has also been shown to regulate Th1/Th2 differentiation.
VE:
1 * 200 µG
Artikel-Nr:
(PRSI92-361)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
92-361
Lokale Artikelnummer::
PRSI92-361
Beschreibung:
CD40 Ligand (CD40LG) is a type II transmembrane glycoprotein that belongs to the TNF superfamily. Like other TNF superfamily members, CD40LG exists as a trimer in membrane bound and soluble form, both of which are bioactive. CD40LG is a ligand for CD40; its ligation also initiates signal transduction in CD40LG expressing cells. CD40LG is a differentiation antigen that is expressed on the surface of T-cells. It stimulates B-cell proliferation and secretion of all immunoglobulin isotypes in the presence of cytokines. CD40LG has been shown to induce cytokine production and tumouricidal activity in peripheral blood monocytes. It also co-stimulates proliferation of activated T-cells and this is accompanied by the production of IFN-gamma, TNF-alpha, and IL2.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI5211P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
5211P
Lokale Artikelnummer::
PRSI5211P
Beschreibung:
UCMA peptide is used for blocking the activity of UCMA antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI90-245)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
90-245
Lokale Artikelnummer::
PRSI90-245
Beschreibung:
Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released upon cell lysis. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.
VE:
1 * 10 µG
Artikel-Nr:
(PRSI91-398)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-398
Lokale Artikelnummer::
PRSI91-398
Beschreibung:
CD177 is polymorphic and has at least two alleles: PRV1 and NB1. Human PRV1 is a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein that belongs to the uPAR/CD59/Ly6 family of receptors. PRV1 is expressed by neutrophils and neutrophil precursors,and changes in expression serve as diagnostic markers for myeloproliferative disorders such as polycythemia vera and essential thrombocythemia. PRV1 may also be expressed by Erythroblasts, B cells, and Monocytes. NB1, a Glycosyl-Phosphatidylinositol (GPI)-linked cell surface glycoprotein, was first described in a case of neonatal alloimmune neutropenia. It is reported that CD177 functions as a novel heterophilic binding partner that engages PECAM-1 in membrane-proximal IgD6.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-554)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-554
Lokale Artikelnummer::
PRSI96-554
Beschreibung:
Interleukin-12 (IL12) is also known as natural killer cell stimulatory factor (NKSF), cytotoxic lymphocyte maturation factor (CLMF) , is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). IL12 is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is involved in the differentiation of naive T cells into Th0 cells and plays an important role in the activities of natural killer cells and T lymphocytes.IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
Interleukin-12 subunit beta (IL12B) also known as NKSF2, CLMF2 and P40. Interleukin-12 subunit beta has been shown to interact with IL23. A large excess of monomeric IL12B is also secreted by the cells producing IL12, and exhibits no demonstrable biological activity. Overexpression of IL12B gene has been shown to be associated with the pathogenesis of multiple sclerosis. In addition, studies have revealed that the promoter polymorphism of this gene is implicated in the severity of atopic and non-atopic asthma in children.
VE:
1 * 20 µG
Artikel-Nr:
(PRSI4475P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4475P
Lokale Artikelnummer::
PRSI4475P
Beschreibung:
Slitrk5 peptide is used for blocking the activity of Slitrk5 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI96-342)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
96-342
Lokale Artikelnummer::
PRSI96-342
Beschreibung:
Human recombinant GCSFR1 (from HEK293 cells)
VE:
1 * 100 µG
Artikel-Nr:
(PRSI4745P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
4745P
Lokale Artikelnummer::
PRSI4745P
Beschreibung:
TRIM30 peptide is used for blocking the activity of TRIM30 antibody.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6743P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6743P
Lokale Artikelnummer::
PRSI6743P
Beschreibung:
NKX2-2 peptide is used for blocking the activity of NKX2-2 antibody.
VE:
1 * 50 µG
Lieferant:
Shenandoah Biotechnology
Beschreibung:
Epstein-Barr virus induced gene 3 (EBI3) is a secreted glycoprotein belonging to the hematopoietin receptor family related to the p40 subunit of interleukin 12 (IL-12). EBI3 expression is induced in B-lymphocytes in response to Epstein-Barr virus infection. EBI3 forms heterodimers with p28 to form interleukin 27 (IL-27), and with p35 to form interleukin 35 (IL-35). Both IL-27 and IL-35 have anti-inflammatory and regulatory activity.
Artikel-Nr:
(PRSI91-809)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-809
Lokale Artikelnummer::
PRSI91-809
Beschreibung:
Cadherin-11, also known as OSF-4, Osteoblast cadherin and CDH11, is a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Cadherins interact with themselves in a homophilic manner in connecting cells, may thus contribute to the sorting of heterogeneous cell types. Cadherin-11 contains five cadherin domains and is mainly expressed in brain. Mature cadherin proteins consists of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. It is shown that cadherin-11 is a viable molecular target for therapeutic intervention in Glioblastoma multiforme.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI91-252)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
91-252
Lokale Artikelnummer::
PRSI91-252
Beschreibung:
Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. During apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i.e., caspase-independent fragmentation of chromosomal DNA. AIFM1 interacts with EIF3G, and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. It binds to DNA in a sequence-independent manner and plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells.
VE:
1 * 50 µG
Artikel-Nr:
(PRSI6161P)
Lieferant:
ProSci Inc.
Hersteller-Artikelnummer::
6161P
Lokale Artikelnummer::
PRSI6161P
Beschreibung:
PION peptide is used for blocking the activity of PION antibody.
VE:
1 * 50 µG
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 noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
Lager für diesen Artikel ist begrenzt, kann aber in einem Lagerhaus in Ihrer Nähe zur Verfügung. Bitte stellen Sie sicher, dass Sie in sind angemeldet auf dieser Seite, so dass verfügbare Bestand angezeigt werden können. Wenn das
noch angezeigt wird und Sie Hilfe benötigen, rufen Sie uns an 1-800-932 - 5000.
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